The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial

Tabaee, Samaneh; Sahebkar, Amirhossein; Aghamohammadi, Tayebe; Pakdel, Manizhe; Dehabeh, Maryam; Sobhani, Seyyed Reza; Alidadi, Mona; Majeed, Muhammed; Mirhafez, Seyed Reza

doi:10.1007/978-3-030-73234-9_13

Cited by 9 publications

(10 citation statements)

References 71 publications

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“…In agreement with our study, a clinical trial by Tabaee et al indicated that daily intake curcumin with piperine supplements could modify lipid profile such as reducing LDL and increasing HDL concentration in AMI patients (Tabaee et al, 2021). Also, Panahi et al realized that consumption of curcuminoids plus piperine reduce cholesterol and LDL cholesterol significantly in NAFLD patients (Panahi et al, 2019) However, the results of some studies were not consistent with the results of our study.…”

Section: Discussionsupporting

confidence: 92%

“…All eight trials were RCTs. Seven studies were conducted using a parallel design (Cicero et al, 2020; Mirhafez et al, 2021; Panahi et al, 2014a; Panahi et al, 2017b; Panahi et al, 2019; Saberi‐Karimian et al, 2020; Tabaee et al, 2021), and one had a cross‐over design (Mohammadi et al, 2013). Articles were published from 2012 through 2021.…”

Section: Resultsmentioning

confidence: 99%

“…MetS are associated with several adverse health outcomes, such as non‐alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), and cardiovascular diseases (CVDs). Numerous studies have confirmed that obesity and dyslipidemia correlate with the development of MetS (Asrih & Jornayvaz, 2015; Eckel, Grundy, & Zimmet, 2005; Harlid, Myte, & Van Guelpen, 2017; Tabaee et al, 2021). According to International Diabetes Federation (IDF), one‐fourth of adults worldwide suffer from MetS(D. Afshari, Shirali, rashnuodi, rais zade dashtaki, & Sahraneshin Samani, 2020).…”

Section: Introductionmentioning

confidence: 92%

“…The results of former studies about the impact of curcumin plus piperine supplements on lipid profiles in patients with MetS are equivocal. Although several investigators have suggested favorable effects from curcumin (Cicero et al, 2020; Panahi et al, 2017b; Panahi et al, 2019; Rahimnia, Panahi, Alishiri, Sharafi, & Sahebkar, 2015; Tabaee et al, 2021), other investigations have not detected any significant impact (Mirhafez et al, 2021; Mohammadi et al, 2013; Panahi, Khalili, Hosseini, Abbasinazari, & Sahebkar, 2014b; Saberi‐Karimian et al, 2020). Therefore, the present meta‐analysis of randomized controlled trials (RCTs) was performed to provide a more accurate and precise estimate of the effect of curcumin plus piperine on lipid profile in patients with MetS and associated disorders.…”

Section: Introductionmentioning

confidence: 99%

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A systematic review and meta‐analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders

Hosseini

Ghavidel

Panahi

et al. 2023

Phytotherapy Research

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Metabolic syndrome is characterized by multiple metabolic disorders. Several studies indicated that curcumin plus piperine could affect lipids profiles in various diseases.The present meta-analysis aims to assess the effect of curcumin plus piperine on lipid profiles in patients with MetS and associated disorders using a systematic review and meta-analysis of randomized controlled trials. Trials were searched by several electronic databases up to May 2022. The Comprehensive Meta-Analysis (CMA) version3 software carried out this systematic review and meta-analysis. Random-effects model and the inverse variance method were used to conduct the meta-analysis. We evaluated the publication bias and heterogeneity of all eligible studies. In addition, subgroup analyses and sensitivity assessments were performed to assess potential sources of heterogeneity. The combined results by the random-effects model demonstrated that curcumin plus piperine significantly decreased total cholesterol and LDL-C in patients suffering from metabolic syndrome. In comparison, the results of the overall effect size did not show any significant change in triglyceride concentrations. Our results were robust in sensitivity analysis and were not dependent on the dose of curcumin, the dose of piperine, and the duration of treatment. Our results showed that co-administration of piperine and curcumin supplementation improves the lipid profile in metabolic syndrome. However, further long-term RCTs are required to ascertain their clinical benefit.

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Section: Discussionsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A systematic review and meta‐analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders

Hosseini

Ghavidel

Panahi

et al. 2023

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

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“…−1.6 ± 7.7, p = 0.002) and a decrease in HbA 1C (-0.3 ± 2.2 vs . + 1.1 ± 1.3, p = 0.002) ( 136 ). From a clinical point of view, it is relevant that curcumin can reduce muscle pain and limit muscle damage associated with statin use, making curcumin a very important supplement in patients with statin intolerance ( 137 ).…”

Section: Curcumin As a Support In The Treatment Of Ascvdmentioning

confidence: 99%

Curcumin - The Nutraceutical With Pleiotropic Effects? Which Cardiometabolic Subjects Might Benefit the Most?

Surma

Sahebkar

Urbański³

et al. 2022

Front. Nutr.

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Despite continuous advances in pharmacotherapy, atherosclerotic cardiovascular disease remains the world's leading killer. Atherosclerosis relates not only to an increased level of cholesterol, but involves the development of atherosclerotic plaques, which are formed as a result of processes including inflammation and oxidative stress. Therefore, in addition to the classical risk factors for ASCVD (such as type 2 diabetes, overweight, obesity, hypertension and metabolic syndrome), residual risk factors such as inflammation and oxidative stress should also be reduced. The most important intervention in ASCVD is prevention, which includes promoting a healthy diet based on products of natural origin. Curcumin, which is often present in the diet, has been demonstrate to confer several benefits to health. It has been shown in numerous clinical trials that curcumin exhibited anti-diabetic, lipid-lowering, antihypertensive, antioxidant and anti-inflammatory effects, as well as promoting weight loss. All this means that curcumin has a comprehensive impact on the most important risk factors of ASCVD and may be a beneficial support in the treatment of these diseases. Recently, it has also been shown that curcumin may have a beneficial effect on the course of SARS-CoV-2 infection and might be helpful in the prevention of long-COVID complications. The aim of this review is to summarize the current knowledge regarding the safety and efficacy of curcumin in the prevention and treatment of cardiometabolic diseases.

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Effects of curcumin/turmeric supplementation on obesity indices and adipokines in adults: A grade‐assessed systematic review and dose–response meta‐analysis of randomized controlled trials

Dehzad

Ghalandari

Nouri

2023

Phytotherapy Research

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In the present study, we explored the effect of curcumin/turmeric supplementation on anthropometric indices of obesity, leptin, and adiponectin. We searched PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar up to August 2022. Randomized clinical trials (RCTs) investigating the impact of curcumin/turmeric on obesity indices and adipokines were included. We applied the Cochrane quality assessment tool to evaluate the risk of bias. The registration number is CRD42022350946. Sixty eligible RCTs, with a total sample size of 3691 individuals were included for quantitative analysis. We found that supplementation with curcumin/turmeric significantly reduced body weight (WMD: −0.82 kg, 95% CI: −1.30, −0.35; p = 0.001), body mass index (WMD: −0.30 kg/m2, 95% CI: −0.53, −0.06, p = 0.013), waist circumference (WMD: −1.31 cm, 95% CI: −1.94, −0.69, p < 0.001), body fat percentage (WMD: −0.88%, 95% CI: −1.51, −0.25, p = 0.007), leptin (WMD = −4.46 ng/mL; 95% CI: −6.70, −2.21, p < 0.001), and increased adiponectin (WMD = 2.48 μg/mL; 95% CI: 1.34, 3.62, p < 0.001). Overall, our study shows that supplementation with curcumin/turmeric significantly improves anthropometric indices of obesity and adiposity‐related adipokines (leptin and adiponectin). However, due to high between‐studies heterogeneity, we should interpret the results with caution.

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The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial

Cited by 9 publications

References 71 publications

A systematic review and meta‐analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders

A systematic review and meta‐analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders

Curcumin - The Nutraceutical With Pleiotropic Effects? Which Cardiometabolic Subjects Might Benefit the Most?

Effects of curcumin/turmeric supplementation on obesity indices and adipokines in adults: A grade‐assessed systematic review and dose–response meta‐analysis of randomized controlled trials

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