The effects of Cordyceps militaris fruiting bodies in micturition and prostate size in benign prostatic hyperplasia patients: A pilot study

Hsieh, Shao-An; Lin, Tien‐Huang; Wang, Jen-Shu; Chen, Jian-Jung; Hsu, Wen-Kuang; Ying, Li-Chih; Liang, Zeng‐Chin

doi:10.1016/j.prmcm.2022.100143

Cited by 4 publications

(3 citation statements)

References 76 publications

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“…However, only a few human studies concerning supplementation with a mushroom mixture (containing, among others, C. militaris ) have shown an improvement in tolerance to high-intensity exercises [ 17 , 18 ]. Additionally, in the latest research in a non-randomized controlled pilot trial, consumption of C. militaris fruiting bodies (as powder in the form of a capsule) by patients with benign prostatic hyperplasia (BPH) contributed to improve the urinary flow, alleviating micturition symptoms and decreasing size of the prostatic gland [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cordyceps militaris—Fruiting Bodies, Mycelium, and Supplements: Valuable Component of Daily Diet

et al. 2022

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Cordyceps militaris has long been used in Eastern medicine for alleviating fatigue and as an immunostimulant. The present study aimed to determine the content of biologically active substances (bioelements and organic compounds), the total phenolic content, and the antioxidant activity of fruiting bodies (commercially available and self-cultivated), mycelia, and two food supplements. The results show that substrate composition and cultivation method had an influence on the properties of mushroom materials. An important aspect of the study is the estimation of the content of bioactive substances present after extraction into digestive juices in the artificial gastrointestinal tract model, which can allow for determining the amount of these substances that is potentially bioavailable for the human body. The best results for cordycepin (81.4 mg/100 g d.w.) and lovastatin (53.6 mg/100 g d.w.) were achieved for commercially available food supplements. Furthermore, after digestion in artificial intestinal juice, the highest amount of cordycepin was determined in the fruiting bodies from commercially obtained (25.9 mg/100 g d.w.) and self-cultivated mushroom (25.8 mg/100 g d.w.). In conclusion, the mycelium and fruiting bodies of C. militaris are ideal food supplements and pharmaceutical agents and can serve as a good source of prohealth substances potentially bioavailable for humans.

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Section: Introductionmentioning

confidence: 99%

Cordyceps militaris—Fruiting Bodies, Mycelium, and Supplements: Valuable Component of Daily Diet

et al. 2022

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“…As per the reports, cordycepin resulted in gastrointestinal and bone marrow toxicity in dogs [ 234 , 235 ], oosporein caused gout in avian species [ 234 , 236 ], and beauvericin might induce apoptosis and cell cytotoxicity [ 237 ]. Clinical trials have been conducted to investigate Cordyceps for immunomodulation [ 238 , 239 , 240 , 241 ], anticancer activity [ 242 ], respiratory function enhancement [ 243 ], insomnia management [ 244 ], prostate problem management [ 245 ], liver dysfunction alleviation [ 246 ], and increased tolerance to high-intensity exercise [ 32 , 247 , 248 ]. However, no clinical studies have investigated its neuroprotective activity.…”

Section: Safety and Toxicitymentioning

confidence: 99%

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

Sharma,

2023

Nutrients

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Cordyceps, also known as “zombie fungus”, is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a “zombie”. These species produce promising bioactive metabolites, like adenosine, β-glucans, cordycepin, and ergosterol. Cordyceps has been used in traditional medicine due to its immense health benefits, as it boosts stamina, appetite, immunity, longevity, libido, memory, and sleep. Neuronal loss is the typical feature of neurodegenerative diseases (NDs) (Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS)) and neurotrauma. Both these conditions share common pathophysiological features, like oxidative stress, neuroinflammation, and glutamatergic excitotoxicity. Cordyceps bioactives (adenosine, N6-(2-hydroxyethyl)-adenosine, ergosta-7, 9 (11), 22-trien-3β-ol, active peptides, and polysaccharides) exert potential antioxidant, anti-inflammatory, and anti-apoptotic activities and display beneficial effects in the management and/or treatment of neurodegenerative disorders in vitro and in vivo. Although a considerable list of compounds is available from Cordyceps, only a few have been evaluated for their neuroprotective potential and still lack information for clinical trials. In this review, the neuroprotective mechanisms and safety profile of Cordyceps extracts/bioactives have been discussed, which might be helpful in the identification of novel potential therapeutic entities in the future.

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“…Its fruiting body can be easily cultivated and contains more metabolites than the vegetative mycelium. C. militaris fruiting body powder and capsules have been found to improve micturition and prostate size in patients with benign prostatic hyperplasia [35].…”

Section: Introductionmentioning

confidence: 99%

Research Progress in Understanding the Molecular Biology of Cordyceps militaris

Wang,

Li,

Tian

et al. 2024

Fermentation

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Cordyceps militaris (C. militaris) is a valued medicinal fungus that can be traced back thousands of years in traditional Chinese medicine (TCM). Both TCM and modern scientific research have confirmed the positive effects of C. militaris on human health. In recent years, C. militaris has gained wide popularity; unfortunately, strains often degrade during cultivation, resulting in a decline in fruiting bodies and active components that negatively impacts the development of C. militaris in the health food and medicine industries. This review summarizes the current progresses in research on the genomic, transcriptomic, proteomic, and genetic manipulation of C. militaris and discusses its primary metabolites and strain degradation mechanisms. The current challenges and future prospects of C. militaris research are also discussed.

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The effects of Cordyceps militaris fruiting bodies in micturition and prostate size in benign prostatic hyperplasia patients: A pilot study

Cited by 4 publications

References 76 publications

Cordyceps militaris—Fruiting Bodies, Mycelium, and Supplements: Valuable Component of Daily Diet

Cordyceps militaris—Fruiting Bodies, Mycelium, and Supplements: Valuable Component of Daily Diet

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

Research Progress in Understanding the Molecular Biology of Cordyceps militaris

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