The effects of continuous administration of murine interleukin-1α in the rat

Otterness, Ivan G.; Seymour, Patricia A.; Golden, Harry; Reynolds, Jack; Daumy, Gaston O.

doi:10.1016/0031-9384(88)90379-4

Cited by 85 publications

(33 citation statements)

References 27 publications

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“…36,37 Otterness et al 38 and Mrosovsky et al 39 observed cachexia-causing effects of IL-1 when it is administrated to animals. Transfection of a cachectic tumor cell line (colon-26) with the gene for IL-1 receptor antagonist failed to abolish the capacity of the tumor to produce cachexia.…”

Section: Interleukin-1 (Il-1)mentioning

confidence: 99%

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Jurdana

2009

Radiology and Oncology

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Section: Interleukin-1 (Il-1)mentioning

confidence: 99%

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Jurdana

2009

Radiology and Oncology

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“…These include decreased locomotor activity (Otterness et al, 1988), exploration (Spadaro and Dunn, 1990;Dunn et al, 1991), and feeding (McCarthy et al, 1985), behaviors that may be displayed by fearful or anxious animals. These well-documented findings raised the question of whether IL-1 may mediate fear or anxiety-like behavior in animals.…”

Section: Introductionmentioning

confidence: 99%

Effects of interleukin-1β and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests

Świergiel

Dunn

2007

Pharmacology Biochemistry and Behavior

183

106

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It has been postulated that infections, inflammatory processes and resulting cytokines may be causative factors in emotional disorders, including depression and anxiety. Support for this possibility has been sought in studies of animal behavior following administration of interleukin-1 (IL-1) and lipopolysaccharide (LPS). However, such treatments induce a variety of behavioral responses, collectively known as sickness behavior, some of which could affect the performance in tests used to assess anxiety and depression. Thus the effects of peripheral administration of IL-1β and LPS on the behavior of mice were studied in the elevated plus-maze (EPM) and the open field (OF). Mouse IL-1β (30, 100, 300, and 1000 ng) was injected intraperitoneally 30 or 60 min, and LPS (0.5, 1 and 5 μg) 120 minutes before the tests.IL-1β and LPS induced dose-dependent decreases in open arm entries and the time spent on the open arms in the EPM, effects considered to reflect anxiety-like behavior. However, entries to all arms were also reduced in a dose-dependent manner, indicating a decrease in general activity. In the OF, IL-1β and LPS decreased the number of line-crossings in the center of the field, that can also be considered to reflect anxiety-like behavior. However, this effect was accompanied by a similar decrease in line-crossings in the periphery, as well as in rears and climbs. Thus the doses of IL-1β and LPS necessary to induce these effects also decreased locomotor activity in the EPM and OF. Therefore, the behavioral responses induced by IL-1β and LPS in the EPM and the OF considered to reflect anxiety must be interpreted in the light of this reduction in overall activity. Thus the results do not provide unequivocal support for the suggestion that LPS or IL-1 mediate anxiety. Nevertheless, because infections, endotoxins, and the ensuing cytokines cause alterations in CNS norepinephrine and serotonin, they may contribute to emotionality, and perhaps to anxiety.

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“…rhIL-1/3 treatment was also associated with a decrease in food intake and body weight gain, which is in good agreement with previous reports. 36 - 38 The effect of rhIL-10 on body weight gain was present during the first 2 days of infusion but had been lost by day 3 of treatment. This is in line with studies demonstrating that tolerance to the anorectic effects of IL-1 develops within a few days.…”

Section: Discussionmentioning

confidence: 99%

Continuous infusion of interleukin-1 beta in rats induces a profound fall in plasma levels of cholesterol and triglycerides.

Hermus

Sweep

Demacker

et al. 1992

Arterioscler Thromb

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During infectious diseases, striking alterations in plasma concentrations of cholesterol (hypocholesterolemia) and triglycerides (hypertrigryceridemia) may occur. It has been suggested that interleukin-1 is a mediator of these alterations. We studied the effects of continuous administration of recombinant human interieukin-10 (rhIL-1/3) on plasma levels of cholesterol and triglycerides. A total of 42 rats were equipped with minipumps loaded with either rhIL-1/3 (delivery rate of 0.5, 2.0, or 4.0 /ig/day i.p. for 1 week) or saline. After 1 day of treatment with rhIL-1/3, plasma cholesterol levels had not changed. On day 2 a remarkable decrease of plasma cholesterol levels was observed in rats treated with 2. 3 -8 The mechanism causing hypocholesterolemia during infectious diseases is unknown. In contrast, plasma levels of triglycerides are usually elevated in bacterial, viral, and parasitic infections, particularly during recovery. "12 In animal models of infection a decrease in the catabolism of circulating trigryceride-rich lipoproteins has been observed.

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The effects of continuous administration of murine interleukin-1α in the rat

Cited by 85 publications

References 27 publications

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Cancer cachexia-anorexia syndrome and skeletal muscle wasting

Effects of interleukin-1β and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests

Continuous infusion of interleukin-1 beta in rats induces a profound fall in plasma levels of cholesterol and triglycerides.

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