The effects of compression rate and force on the compaction properties of different viscosity grades of hydroxypropylmethylcellulose 2208

Nokhodchi, Ali; Ford, James L.; Rowe, Philip H.; Rubinstein, Michael

doi:10.1016/0378-5173(95)04236-9

Cited by 56 publications

(36 citation statements)

References 15 publications

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“…On the other hand, the hardness of the tablets statistically increased (P<0.05) with increasing viscosity grade of HPMC, and the use of HV-HPMC presented the highest tablet hardness. This result was in agreement with a previous study (24). The tablets gave acceptable physical properties because HPMC had a good compressibility and showed plastic deformation under compression with small elastic recovery when using low compression speed (24), which was similar to the use of hydrostatic press for tableting that had a slow speed for tablet compression.…”

Section: Effect Of Hpmc Viscosity Grade On Characteristics Of Nct-massupporting

confidence: 81%

Influence of pH Modifiers and HPMC Viscosity Grades on Nicotine–Magnesium Aluminum Silicate Complex-Loaded Buccal Matrix Tablets

Kanjanabat

2012

AAPS PharmSciTech

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Abstract. Hydroxypropyl methylcellulose (HPMC) tablets containing nicotine-magnesium aluminum silicate (NCT-MAS) complex particles and pH modifiers, namely, sodium chloride, citric acid, and magnesium hydroxide, were prepared using the direct compression method. The effects of HPMC viscosity grades and pH modifiers on NCT release and permeation of the matrix tablets were examined. The results showed that the higher the viscosity grade of HPMC that was used in the tablets, the lower was the unidirectional NCT release rate found. The unidirectional NCT permeation was not affected by the viscosity grade of HPMC because the NCT diffusion through the mucosal membrane was the rate-limiting step of the permeation. Incorporation of magnesium hydroxide could retard NCT release, whereas the enhancement of unidirectional NCT release was found in the tablets containing citric acid. Citric acid could inhibit NCT permeation due to the formation of protonated NCT in the swollen tablets at an acidic pH. Conversely, the NCT permeation rate increased with the use of magnesium hydroxide as a result of the neutral NCT that formed at a basic microenvironmental pH. The swollen HPMC tablets, with or without pH modifiers, gave sufficient adhesion to the mucosal membrane. Furthermore, the addition of magnesium hydroxide to the matrix tablets was the major factor in controlling buccal delivery of NCT. This study suggests that the NCT-MAS complex-loaded HPMC tablets, which contained magnesium hydroxide, are potential buccal delivery systems of NCT.KEY WORDS: buccal tablet; hydroxypropyl methylcellulose; magnesium aluminum silicate; nicotine; pH modifier.

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Section: Effect Of Hpmc Viscosity Grade On Characteristics Of Nct-massupporting

confidence: 81%

Influence of pH Modifiers and HPMC Viscosity Grades on Nicotine–Magnesium Aluminum Silicate Complex-Loaded Buccal Matrix Tablets

Kanjanabat

2012

AAPS PharmSciTech

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“…Figure 10 shows the effect of compression methods on elastic recovery. This parameter is associated with interparticulate friction or bonding (31). There was no significant difference in elastic recovery among the compression methods.…”

Section: Evaluation Of Compression Properties Using Microcelacmentioning

confidence: 87%

Characterization of Tableting using the OSDRC System

2007

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“…Escudero et al, 2008;Nokhodchi et al, 1996b;Nokhodchi and Rubinstein, 2001 Humidity Higher moisture content leads to increased tensile strength of tablets. Nokhodchi et al, 1996a;Nokhodchi et al, 1996c;Rajabi-Siahboomi et al, 1998;Nokhodchi and Rubinstein, 2001; Parikh 2016 (Nokhodchi et al, 1996c). The strain-rate sensitivity, which is the ability of the material to resist necking, increased from 21.6 to 50.7 % as the moisture content increased from 0 to 14.9% w/w, indicating that the plasticity of HPMC increased with an increase in moisture content (Nokhodchi et al, 1996c).…”

Section: Factors Effect Referencesmentioning

confidence: 99%

“…It was reported by Nokhodchi et al (1996a) that as the viscosity of HPMC decreases, the ability of powder particles to deform plastically increases and the tensile strength of HPMC K100 is much higher than other HPMC grades as a consequence of its viscosity. The increase in molecular weight might affects the material's ability to deform.…”

Section: Effect Of Molecular Sizementioning

confidence: 99%

Powder Compaction: Compression Properties of Cellulose Ethers

Ghori

Conway

2016

British Journal of Pharmacy

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Effective development of matrix tablets requires a comprehensive understanding of different raw material attributes and their impact on process parameters. Cellulose ethers (CE) are the most commonly used pharmaceutical excipients in the fabrication of hydrophilic matrices. The innate good compression and binding properties of CE enable matrices to be prepared using economical direct compression (DC) techniques. However, DC is sensitive to raw material attributes, thus, impacting the compaction process. This article critically reviews prior knowledge on the mechanism of powder compaction and the compression properties of cellulose ethers, giving timely insight into new developments in this field.

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The effects of compression rate and force on the compaction properties of different viscosity grades of hydroxypropylmethylcellulose 2208

Cited by 56 publications

References 15 publications

Influence of pH Modifiers and HPMC Viscosity Grades on Nicotine–Magnesium Aluminum Silicate Complex-Loaded Buccal Matrix Tablets

Influence of pH Modifiers and HPMC Viscosity Grades on Nicotine–Magnesium Aluminum Silicate Complex-Loaded Buccal Matrix Tablets

Characterization of Tableting using the OSDRC System

Powder Compaction: Compression Properties of Cellulose Ethers

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