The effects of combined treatment with ionizing radiation and indocyanine green-mediated photodynamic therapy on breast cancer cells

Montazerabadi, Alireza; Sazgarnia, Ameneh; Bahreyni-Toosi, Mohammad Hossein; Ahmadi, Amirhossein; Aledavood, Amir

doi:10.1016/j.jphotobiol.2012.01.004

Cited by 61 publications

(53 citation statements)

References 39 publications

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“…As described earlier, combination of ICG with NIR laser irradiation results in excitation of the photosensitizer that induces the photooxidative and subsequent cytotoxic effects of PDT on cancer cells (31)(32)(33). The induction of DNA and protein damage mediated by generation of ROS in this process has been well established and characterized in the literature (34).…”

Section: Cytotoxicity Assessment Pdt Across the Pig Ear Skinmentioning

confidence: 88%

“…Mice were initially quarantined and acclimatized for 1 week following arrival. Tumor growth was induced by subcutaneous implantation of human TNBC MDA-MB-468 cells (4×10 6 in a 0.1 mL matrigel/DMEM mixture) on the right and left lower flanks of the mice (31,32). Tumor-bearing animals were then allowed to reach mean tumor volumes of 50-100 mm 3 followed by randomization of the mice into appropriate treatment and controls groups.…”

Section: Tumor Xenograft Murine Modelmentioning

confidence: 99%

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Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

2014

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Section: Cytotoxicity Assessment Pdt Across the Pig Ear Skinmentioning

confidence: 88%

Section: Tumor Xenograft Murine Modelmentioning

confidence: 99%

Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

2014

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“…1 Radiotherapy plays an important role in preventing metastasis and the regeneration of tumor tissue; however, normal tissue close to the tumor is inevitably exposed to radiation during administration, especially chest and abdominal tissue moving because of respiration.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells

Chen¹,

Zhang²,

Hu³

et al. 2015

IJN

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Radiotherapy is one of the main strategies for cancer treatment but has significant challenges, such as cancer cell resistance and radiation damage to normal tissue. Radiosensitizers that selectively increase the susceptibility of cancer cells to radiation can enhance the effectiveness of radiotherapy. We report here the development of a novel radiosensitizer consisting of monodispersed ceria nanoparticles (CNPs) covered with the anticancer drug neogambogic acid (NGA-CNPs). These were used in conjunction with radiation in MCF-7 breast cancer cells, and the efficacy and mechanisms of action of this combined treatment approach were evaluated. NGA-CNPs potentiated the toxic effects of radiation, leading to a higher rate of cell death than either treatment used alone and inducing the activation of autophagy and cell cycle arrest at the G2/M phase, while pretreatment with NGA or CNPs did not improve the rate of radiation-induced cancer cells death. However, NGA-CNPs decreased both endogenous and radiation-induced reactive oxygen species formation, unlike other nanomaterials. These results suggest that the adjunctive use of NGA-CNPs can increase the effectiveness of radiotherapy in breast cancer treatment by lowering the radiation doses required to kill cancer cells and thereby minimizing collateral damage to healthy adjacent tissue.

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“…With regard to breast cancer, several in vitro studies have shown a synergism between PDT and ionizing radiation in killing cells. The combined application of nontoxic doses of indocyanine green [10] , rhodamine 123 and its platinum complex [11] , zinc phthalocyanine and meso-tetrahydroxyphenylchlorine [12] with light proved to be very effective and resulted in a nearly complete reduction of survival. These reports suggest that treatment of tumors with a combination of PS-mediated PDT and ionizing radiation could be superior to their individual use.…”

Section: Pdt Combined With Conventional Breast Cancer Therapiesmentioning

confidence: 99%

Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity

Lamberti

Vittar

Rivarola

2014

WJCO

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Photodynamic therapy is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with specific light activation of a photosensitizer agent. Whereas interstitial and intra-operative approaches have been investigated for the ablation of a broad range of superficial or bulky solid tumors such as breast cancer, the majority of approved photodynamic therapy protocols are for the treatment of superficial lesions of skin and luminal organs. This review article will discuss recent progress in research focused mainly on assessing the efficacies of various photosensitizers used in photodynamic therapy, as well as the combinatory strategies of various therapeutic modalities for improving treatments of parenchymal and/or stromal tissues of breast cancer solid tumors. Cytotoxic agents are used in cancer treatments for their effect on rapidly proliferating cancer cells. However, such therapeutics often lack specificity, which can lead to toxicity and undesirable side effects. Many approaches are designed to target tumors. Selective therapies can be established by focusing on distinctive intracellular (receptors, apoptotic pathways, multidrug resistance system, nitric oxidemediated stress) and environmental (glucose, pH) differences between tumor and healthy tissue. A rational design of effective combination regimens for breast cancer treatment involves a better understanding of the mechanisms and molecular interactions of cytotoxic agents that underlie drug resistance and sensitivity. Key words: Photodynamic therapy; Breast cancer; Tumor microenvironment; Treatment combination; Synergism Core tip: Breast cancer is the most common cancer in women worldwide. However, effective therapies that reduce the high mortality rate and improve patient quality of life are still unavailable. In recent years, the use of photodynamic therapy has been examined for use in breast cancer treatment. Photodynamic therapy provides a new and promising antitumor strategy that could be implemented, alone or in combination with other approved or experimental therapeutic approaches, to a wide range of applications.

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The effects of combined treatment with ionizing radiation and indocyanine green-mediated photodynamic therapy on breast cancer cells

Cited by 61 publications

References 39 publications

Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells

Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity

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The effects of combined treatment with ionizing radiation and indocyanine green-mediated photodynamic therapy on breast cancer cells

Cited by 61 publications

References 39 publications

Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

Thermosensitive Liposome Formulated Indocyanine Green for Near-Infrared Triggered Photodynamic Therapy: In Vivo Evaluation for Triple-Negative Breast Cancer

Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in&nbsp;breast cancer cells

Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity

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Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells