The effects of combination treatment with LT4 and LT3 on diastolic functions and atrial conduction time in LT4-treated women with low T3: a short term follow-up study

Abstract

To investigate the effects of combination thyroid replacement treatment on left atrial volume (LAV), diastolic functions, and atrial electromechanical delays in women with low triiodothyronine (T3) levels. MethodsThe study consisted of forty-seven female patients with primer hypothyroidism. The patients who had low T3 levels, despite using tetraiodothyronine (T4) treatment for a while with normal thyrotropin (TSH) and T4 levels with levothyroxine (LT4) treatment and started combination therapy were included in the study. Biochemical samples (TSH, free T4, free T3) were taken, and an echocardiographic assessment was performed for patients at rst admission and after approximately six months of receiving T3 (12.5 mcg) treatment. ResultsThere was a statistically signi cant reduction at left ventricle (LV) end-systolic diameter (