The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

Duedu, Kwabena Obeng; Sagoe, Kwamena W.; Ayeh‐Kumi, Patrick F.; Affrim, R.B; Adiku, Theophilus

doi:10.1016/s2221-1691(13)60037-4

Cited by 20 publications

(20 citation statements)

References 87 publications

(117 reference statements)

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“…In contrast, other studies from Malawi [22], Ghana [8], and Kenya [20,45] found little evidence of acute B19V infection in children (either anemic or control).…”

Section: Discussionmentioning

confidence: 87%

“…The B19V-infection outbreak in Nigeria reported that 54% of children with P. falciparum associated severe anemia (hematocrit level, <20%) showed an evidence of B19V-infection [7]. Similar studies from Ghana, Papua New Guinea, and Kenya support the finding that B19V can play an important role in the etiology of severe anemia in children living in malaria endemic areas [8,20,21]. However, other studies from Malawi [22] and Kenya [23] observed little evidence of acute B19V-infection in severe anemia in children with malaria.…”

Section: Introductionmentioning

confidence: 78%

“…The clinical resolution is influenced by multitude of host and parasite factors [2]. Recent studies have underlined the importance of co-infection with human Parvovirus B19 (B19V) in the etiology and pathogenesis of P. falciparum malaria both in adults and in children [3-8]. The B19V infection occurs worldwide, with more than 50% are infected with B19V during early childhood with highest reported cases among children from tropical countries [7,9].…”

Section: Introductionmentioning

confidence: 99%

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Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

Toàn

Song

et al. 2013

BMC Infect Dis

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BackgroundHigh seroprevalence of parvovirus B19 (B19V) coinfection with Plasmodium falciparum has been previously reported. However, the impact of B19V-infection on the clinical course of malaria is still elusive. In this study, we investigated the prevalence and clinical significance of B19V co-infection in Gabonese children with malaria.MethodsB19V prevalence was analyzed in serum samples of 197 Gabonese children with P. falciparum malaria and 85 healthy controls using polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA), and direct DNA-sequencing.ResultsB19V was detected in 29/282 (10.28%) of Gabonese children. B19V was observed more frequently in P. falciparum malaria patients (14.21%) in comparison to healthy individuals (1.17%) (P<0.001). Notably, the mild-malaria group revealed significantly lower hematocrit levels in B19V/P. falciparum co-infection than in P. falciparum mono-infection (P<0.05). Genetic analysis revealed a predominance of B19V genotype-1 (71.43%) in the studied population. However, B19V-genotype 2 was observed significantly more often in children with severe-malaria than in mild-malaria (P=0.04).ConclusionOur findings reveal that B19V-infection is frequent in Gabonese children with P. falciparum malaria and signifies a possible contribution of B19V on the clinical course of malaria in a genotype-dependent manner. B19V co-infection should be considered as a additional diagnostic measure in malaria patients with life threatening anemia.

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“…In contrast, other studies from Malawi [22], Ghana [8], and Kenya [20,45] found little evidence of acute B19V infection in children (either anemic or control).…”

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

Toàn

Song

et al. 2013

BMC Infect Dis

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“…In children with only sub-microscopic parasitemia, it is uncertain whether fevers can be ascribed to malaria, and in fact many children had both P. falciparum and additional microbes identified. Interestingly, three of the four cases of parvovirus B19 were found in association with P. falciparum; this co-infection has been associated with severe anemia with life-threatening consequences [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda

et al. 2019

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Febrile illness is a major burden in African children, and non-malarial causes of fever are uncertain. In this retrospective exploratory study, we used metagenomic next-generation sequencing (mNGS) to evaluate serum, nasopharyngeal, and stool specimens from 94 children (aged 2–54 months) with febrile illness admitted to Tororo District Hospital, Uganda. The most common microbes identified were Plasmodium falciparum (51.1% of samples) and parvovirus B19 (4.4%) from serum; human rhinoviruses A and C (40%), respiratory syncytial virus (10%), and human herpesvirus 5 (10%) from nasopharyngeal swabs; and rotavirus A (50% of those with diarrhea) from stool. We also report the near complete genome of a highly divergent orthobunyavirus, tentatively named Nyangole virus, identified from the serum of a child diagnosed with malaria and pneumonia, a Bwamba orthobunyavirus in the nasopharynx of a child with rash and sepsis, and the genomes of two novel human rhinovirus C species. In this retrospective exploratory study, mNGS identified multiple potential pathogens, including 3 new viral species, associated with fever in Ugandan children.

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“…Based on seroprevalence studies, it has been demonstrated that human parvovirus B19V is actively circulating worldwide without neither ethnical nor geographical boundaries, albeit with some regional differences (Chorba et al, 1986;Brown et al, 2001;Mossong et al, 2008;Salimi et al, 2008;Molar-de Backer et al, 2012;Duedu et al, 2013). Acquisition is often during childhood and continues at lower rates throughout adulthood such that between 70 and 85% of adults show serologic evidence of past infection (Cohen and Buckley, 1988;Kelley et al, 2000).…”

Section: Epidemiologymentioning

confidence: 99%

Human parvovirus B19: A review

Rogo¹,

Mokhtari‐Azad²,

Kabir³

et al. 2014

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Summary. -Parvovirus B19 (B19V) is a small non-enveloped single-stranded DNA (ssDNA) virus of the family Parvoviridae, the subfamily Parvovirinae, the genus Erythrovirus and Human parvovirus B19 type species. It is a common community-acquired respiratory pathogen without ethnic, socioeconomic, gender, age or geographic boundaries. Moreover, the epidemiological and ecological relationships between human parvovirus B19, man and environment have aroused increasing interest in this virus. B19V infection is associated with a wide spectrum of clinical manifestations, some of which were well established and some are still controversial, however, it is also underestimated from a clinical perspective. B19V targets the erythroid progenitors in the bone marrow by binding to the glycosphingolipid globoside (Gb4), leading to large receptor-induced structural changes triggering cell death either by lysis or by apoptosis mediated by the nonstructural (NS)1 protein. The pattern of genetic evolution, its peculiar properties and functional profile, the characteristics of its narrow tropism and restricted replication, its complex relationship with the host and its ample pathogenetic potential are all topics that are far from a comprehensive understanding. The lack of efficient adaptation to in vitro cellular cultures and the absence of animal models have limited classical virological studies and made studies on B19V dependent on molecular biology. The present review looks at the nature of this virus with the view to provide more information about its biology, which may be useful to the present and future researchers.Keywords: human parvovirus B19; respiratory pathogen; biology; genome; fifth disease; transient aplastic crisis; anemia * Corresponding author. E-mail: rezaie@tums.ac.ir; phone: +982188982343. Abbreviations: B19V = parvovirus B19; Gb4 = glycosphingolipid globoside; IL-6 = interleukin 6; IVIG = intravenous immunoglobulin G; MHC = major histocompatibility class; SF3-helicase = superfamily 3 helicase; NS = nonstructural; TNF-α = tumor necrosis factor α; VLPs = virus like particles; VP1 = viral protein 1; VP2 = viral protein 2

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The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

Cited by 20 publications

References 87 publications

Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda

Human parvovirus B19: A review

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