The effects of cigarette smoking behavior and psychosis history on general and social cognition in bipolar disorder

Ospina, Luz H.; Russo, Manuela; Nitzburg, George M; Cuesta-Diaz, Armando; Shanahan, Megan; Perez‐Rodriguez, M. Mercedes; Mcgrath, Meaghan; Levine, Hannah; Mulaimovic, Sandra; Burdick, Katherine E.

doi:10.1111/bdi.12420

Cited by 8 publications

(2 citation statements)

References 75 publications

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“…Nicotine improved performance for individuals who scored poorly at baseline, but impaired performance for those who performed well at baseline. A similar moderation effect of nicotine’s impact on social functioning by baseline performance was observed in a study that was not included in this review, because it did not experimentally manipulate nicotine (Ospina et al, 2016). In summary, across a variety of methods and measures, nicotine administration appears to consistently enhance social functioning.…”

Section: Resultssupporting

confidence: 59%

A review of the effects of nicotine on social functioning.

Martin

Sayette

2018

Experimental and Clinical Psychopharmacology

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Many smokers are aware that smoking is a dangerous health behavior and eventually try to quit smoking. Unfortunately, most quit attempts end in failure. Traditionally, the addictive nature of smoking has been attributed to the pharmacologic effects of nicotine. In an effort to offer a more comprehensive, biobehavioral analysis of smoking behavior and motivation, some researchers have begun to consider the role of social factors in smoking. In line with recent recommendations to integrate social and pharmacological analyses of smoking, we reviewed the experimental literature examining the effects of nicotine and nicotine withdrawal on social functioning. The review identified 13 studies that experimentally manipulated nicotine and assessed social functioning, 12 of which found support for nicotine's enhancement of social functioning. Although few experiments have investigated social functioning, they nevertheless offer compelling evidence that nicotine enhances social functioning in smokers and suggest that nicotine deprivation may hamper social functioning in those dependent on nicotine. Future directions for investigating social outcomes and context in those who use nicotine products are discussed with a focus on leveraging advances in social and developmental psychology, animal research, sociology, and neuroimaging to more comprehensively understand smoking behavior. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

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Section: Resultssupporting

confidence: 59%

A review of the effects of nicotine on social functioning.

Martin

Sayette

2018

Experimental and Clinical Psychopharmacology

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“…However, different risk factors of cognitive impairment have been shown for this specific group, including aging effects, 6,8 unhealthy lifestyle, 9 reduced cognitive reserve, 10,11 and high burden of vascular comorbidities. 12,13 The underlying causal pathways are poorly understood.…”

mentioning

confidence: 99%

Homocysteine, rather than age of onset, is a better predictor for cognitive function in older adults with bipolar disorder

Chen

Liu

et al. 2019

Int J Geriat Psychiatry

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Objectives The association between older‐age bipolar disorder and cognitive impairments may be mediated by vascular burden. The aim of the study was to examine the difference of cognitive function between older people with late‐onset bipolar disorder (LOBD) and early‐onset bipolar disorder (EOBD) by considering rigorous vascular risk burden evaluation, comprehensive cognitive tests, and relevant biochemistry data. Methods We recruited 95 outpatients aged over 55 with a DSM‐IV‐TR diagnosis of bipolar I disorder. Fifty had LOBD, defined by age of onset after 40. Cognitive function was evaluated through a battery of tests assessing verbal memory, attention/speed, visuospatial function, verbal fluency, and cognitive flexibility. Vascular risk assessments included individual disorders, 10‐year Framingham cardiovascular risk scores, and serum levels of homocysteine, vitamin B12, folate, and triiodothyronine. Results No differences were observed between LOBD and EOBD on any cognitive test after adjusting for potential confounders. In addition to age and educational years, multiple linear regression analyses indicated significantly negative associations between serum homocysteine levels and cognitive performances in attention, psychomotor speed, verbal memory, and executive function. Conclusions Among older people with bipolar disorder, LOBD is not associated with more cognitive dysfunction in this study. However, higher serum homocysteine levels were significantly associated with worse cognitive performance in this particular group. Clinicians therefore have to pay attention to the cognitive function in older bipolar patients with higher levels of homocysteine.

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