The effects of chrysin and naringin on cyclophosphamide-induced erythrocyte damage in rats: biochemical evaluation of some enzyme activities in vivo and in vitro

Temel, Yusuf; Çağlayan, Cüneyt; Ahmed, Barzan Mirza; Kandemir, Fatih Mehmet; Çiftçi, Mehmet

doi:10.1007/s00210-020-01987-y

Cited by 17 publications

(11 citation statements)

References 54 publications

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“…This current investigation shows that the rats treated with CYCP showed a remarkable increase in the levels of erythrocytes • NO; this agrees with previous reports that CYCP-mediated significant increase in erythrocytes • NO and NOS levels [ 43 ].…”

Section: Discussionsupporting

confidence: 93%

“…Our results showed that erythrocytes LDH functions and activities in the CYCP alone group decreased significantly compared with the counterpart negative control (normal) group. The observed dynamics in both serum and erythrocytes compartments might be ascribed to erythrocyte deformity initiated by CYCP-induced erythrocyte ghost non-enzymatic oxidative degradation of PUFAs and protein cross-linking, oxidative stress, cytoplasmic cellular leakage, deterioration in the functional integrity of erythrocytes ghost, and eryptosis [ 4 , 5 , 43 ]. This observation agrees with the earlier study that CYCP intoxication remarkably elevated serum LDH [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

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Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress

et al. 2021

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress

et al. 2021

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“…Moreover, chrysin regulates abnormal changes in enzyme activities induced by commonly used anticancer drugs, such as cyclophosphamide. This is confirmed by the results of the study on the effect of chrysin on the regulation of the pentose phosphate pathway enzymes (playing a pivotal role in cancer cell proliferation) and the enzymes of the reduced glutathione and thiorodexin system, which take part in intramolecular ROS removal [65].…”

Section: Influence Of Chrysin On Side Effects Associated With Pharmacotherapysupporting

confidence: 68%

Chrysin: Perspectives on Contemporary Status and Future Possibilities as Pro-Health Agent

2021

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Chrysin belongs to the group of natural polyphenols. It can be found, among others, in honey, propolis and fruits and has a wide range of biological activities, including the prevention of oxidative stress, inflammation, neurodegeneration and carcinogenesis. Being a part of the human diet, chrysin is considered to be a promising compound to be used in the prevention of many diseases, including cancers, diabetes and neurodegenerative diseases such as Alzheimer’s or Parkinson’s. Nevertheless, due to the low solubility of chrysin in water and under physiological conditions, its bioavailability is low. For this reason, attempts at its functionalization have been undertaken, aiming to increase its absorption and thus augment its in vivo therapeutic efficacy. The aim of this review is to summarize the most recent research on chrysin, including its sources, metabolism, pro-health effects and the effects of its functionalization on biological activity and pharmacological efficacy, evaluated both in vitro and in vivo.

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“…[18] It has numerous physiological and pharmacological actions like antioxidant, antidiabetic, anti-inflammatory, antiradical, antiapoptotic, and neuroprotective properties. [19][20][21][22] However, there is no report on the effect of NRG against OXL-induced peripheral neuropathy in rats. Hence, the present study investigates the protective effect of NRG against OXL-induced toxicity in sciatic nerves using behavioral studies, as well as biochemical and molecular analysis to arrive at a conclusion.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of naringin against oxaliplatin‐induced peripheral neuropathy in rats: A behavioral and molecular study

Semis

Kandemir

Çağlayan

et al. 2022

J Biochem & Molecular Tox

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Oxaliplatin (OXL) is a chemotherapeutic drug used for metastatic and other types of cancer, but it causes peripheral neuropathy as a dose‐limiting side effect. Herein, we used the rat model of OXL‐induced peripheral neuropathy to demonstrate the protective effects of naringin (NRG) in this neuropathy. In this study, rats were injected with OXL (4 mg/kg, body weight, i.p.) in 5% glucose solution 30 min after oral administration of NRG (50 and 100 mg/kg, body weight) on the 1st, 2nd, 5th, and 6th days. OXL caused sensory and motor neuropathy (as revealed by the hot plate, tail flick, rota‐rod, and cold hyperalgesia tests) in the sciatic nerve of rats. Coadministration of oral NRG alleviated OXL‐induced sensory and motor neuropathy. Levels of superoxide dismutase, catalase, glutathione peroxidase, nuclear factor erythroid 2‐related factor 2, Heme oxygenase‐1, nuclear factor‐κ B, tumor necrosis factor‐α, interleukin‐1β, Bax, Bcl‐2, caspase‐3, paraoxonase, mitogen‐activated protein kinase 14, neuronal nitric oxide synthase (nNOS), acetylcholinesterase, and arginase 2 in the sciatic nerve tissues were assessed by real‐time polymerase chain reaction. Moreover, the protein levels of caspase‐3, Bax, Bcl‐2, intercellular adhesion molecules‐1, glial fibrillary acidic protein, and nNOS were examined by Western blot analysis. NRG treatment significantly improved all the above‐mentioned parameters and reduced OXL‐induced oxidative stress, inflammation, and apoptosis in the sciatic nerve tissue. In conclusion, this study demonstrated that NRG significantly attenuated OXL‐induced peripheral neuropathy and might be considered as a new protective agent to prevent the OXL‐induced peripheral neuropathy.

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The effects of chrysin and naringin on cyclophosphamide-induced erythrocyte damage in rats: biochemical evaluation of some enzyme activities in vivo and in vitro

Cited by 17 publications

References 54 publications

Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress

Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress

Chrysin: Perspectives on Contemporary Status and Future Possibilities as Pro-Health Agent

Protective effect of naringin against oxaliplatin‐induced peripheral neuropathy in rats: A behavioral and molecular study

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