The effects of chronic zoledronate usage on the jaw and long bones evaluated using RANKL and osteoprotegerin levels in an animal model

Çankaya, Mustafa; Şenel, Figen Çizmeci; Kadıoğlu, Mine; Muci, Efnan; Dayisoylu, Ezher Hamza; Balaban, F.

doi:10.1016/j.ijom.2013.02.008

Cited by 21 publications

(17 citation statements)

References 27 publications

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“…It is generally recognized that BRONJ pathogenesis is multifactorial. [27] Mostly accepted theories are as follows: high bone turnover of the jaws, the inhibition of angiogenesis, osteoclastic apoptosis and easy bacterial contamination of jaw bone are among the most accepted theories. [9,12,20] Osteoclastic activity in the jaw bone-containing BPs is suppressed and tissue healing would be altered.…”

Section: Resultsmentioning

confidence: 99%

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Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Duygu

Sapmaz-Metin

Kütan

et al. 2016

Biotechnology & Biotechnological Equipment

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The aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Group III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels' analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats.

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Section: Resultsmentioning

confidence: 99%

“…Clinical inspection was made blindly by one of the authors. [27] Histological and histomorphometrical analysis…”

Section: Clinical Findings Assessmentmentioning

confidence: 99%

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Duygu

Sapmaz-Metin

Kütan

et al. 2016

Biotechnology & Biotechnological Equipment

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“…Because of its convenience of administration (the intravenous route is typically selected to prevent gastrointestinal irritation), its long administration interval (often 4–5 mg, once a year for OP and once a month for oncology patients) and, most importantly, its strong anti‐bone resorption effect, ZA has become a new treatment choice. Moreover, ZA is more commonly used in creating BRONJ animal models (Çankaya et al, ; Stephen, Brynmor, Gregory, Mark, & Kenneth, ; Zandi, Dehghan, Malekzadeh, et al, ) than denosumab, because the latter is a human antibody and thus could not be used directly in animal experimentation.…”

Section: Discussionmentioning

confidence: 99%

The effects of different doses of teriparatide on bisphosphonate‐related osteonecrosis of the jaw in mice

2020

Oral Diseases

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Objectives This study aimed to investigate the therapeutic effect of different doses of teriparatide (TPTD) on bisphosphonate‐related osteonecrosis of the jaw (BRONJ). Materials and Methods To establish the BRONJ model, 20 mice were randomly divided into two groups: a group that received tail vein administration of zoledronic acid with dexamethasone (ZA‐125 µg/kg, DEX 5 mg/kg) and a group that received saline weekly. The mice subsequently underwent bilateral maxillary first molar extraction. After 8 weeks of modelling administration, the maxilla samples were examined by micro‐computed tomography and histological staining (haematoxylin and eosin, Masson's trichrome and tartrate‐resistant acid phosphatase) and the cytokine level was measured (enzyme‐linked immunosorbent assay and Western blot). To determine the role of TPTD in BRONJ, the same protocol as previously described was applied in 100 mice (80 received ZA + DEX, and 20 received saline). After 8 weeks of modelling administration, 80 ZA + DEX mice were randomly divided into four groups: three groups with subcutaneous administration of TPTD (i.e. T1‐3, T2‐10 and T3‐30 µg kg−1 day−1) and one group with saline daily for the next 8 weeks. The other 20 saline mice continued to receive saline daily. Results In Part 1, the level of receptor activator of nuclear factor‐kappa Β ligand and the numbers of osteoclasts differed between the model and control groups. In Part 2, we found that TPTD had a positive effect on BRONJ in a mouse model based on clinical and histomorphological observations. Among the three treatment groups, the T1 and T2 groups significantly differed from the model group, whereas the T3 group showed no statistical differences. Conclusion Subcutaneous administration of TPTD has a beneficial effect on BRONJ in mice. Nevertheless, further studies are needed to determine whether the therapeutic effect on BRONJ is dose‐dependent.

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“…Recent studies on MRONJ have used rat models. 9,[11][12][13] In accord with previous animal studies, all rats were injected intraperitoneally with zoledronic acid (0.4 mg/kg once a week) for 7 weeks. In addition, all rats were injected with dexamethasone (1 mg/kg intraperitoneally weekly at weeks 5, 6, and 7).…”

Section: Methodsmentioning

confidence: 99%

Histopathological Effects of Teriparatide in Medication-Related Osteonecrosis of the Jaw: An Animal Study

Keskinruzgar

Bozdağ

Aras

et al. 2016

Journal of Oral and Maxillofacial Surgery

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The effects of chronic zoledronate usage on the jaw and long bones evaluated using RANKL and osteoprotegerin levels in an animal model

Cited by 21 publications

References 27 publications

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

The effects of different doses of teriparatide on bisphosphonate‐related osteonecrosis of the jaw in mice

Histopathological Effects of Teriparatide in Medication-Related Osteonecrosis of the Jaw: An Animal Study

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