The Effects of Chronic Unilateral Renal Artery Constriction on Blood Pressure, Separate Renal Function, and the Development of Collateral Circulation in the Dog

Zweig, S. M.; Rapoport, A.; Wilson, Donald R.; Ranking, G. N.; Husdan, H.

doi:10.1139/y72-171

Cited by 7 publications

(4 citation statements)

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“…Some studies on the split renal function have been done in experimental RVH in animals [8][9][10]. In these studies it was indicated that GFR, the RAA system and undefined other factors were involved in sodium home ostasis, in which the nonclipped kidney compensated for the reduced sodium excretion in the clipped kidney.…”

Section: Discussionmentioning

confidence: 99%

Role of Sodium and Renal Prostaglandin E<sub>2</sub> in the Maintenance of Hypertension in the Chronic Phase of Two-Kidney One-Clip Renovascular Hypertension in Rabbits

Machida

Ueda

Yoshida

et al. 1988

Nephron

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To study the role of sodium and renal prostaglandin E₂ in the chronic phase of two-kidney one-clip renovascular hypertension, urinary excretion rates of sodium and prostaglandin E₂ were measured in rabbits with hypertension induced by left renal artery constriction during alteration in sodium intake. The arterial blood pressure, the increasing rate of body weight and sodium balance during alteration in sodiurm intake were directly proportional to the amount of sodium intake in the hypertensive rabbits, but not in the control ones. Plasma renin activity and plasma aldosterone concentration, which had no significant difference between hypertensive and control rabbits, were inversely proportional to the amount of sodium intake in both rabbits. Urinary excretion rates of sodium in the clipped kidneys of the hypertensive rabbits were significantly lower than the control values in all dietary regimens (p < 0.01). Urinary excretion rates of sodium in the nonclipped kidneys were not significantly higher and in the total kidneys were significantly lower than the corresponding control values during sodium load (p < 0.01). Urinary excretion rates of prostaglandin E₂ were inversely proportional to the amount of sodium intake in both groups. Urinary excretion rates of prostaglandin E₂ in the clipped kidneys were significantly lower than the control values in all dietary regimens (p < 0.001). Urinary excretion rates of prostaglandin E₂ in the nonclipped kidneys were significantly higher during sodium restriction (p < 0.01) but not during sodium load than the control values. Furthermore, urinary excretion rates of prostaglandin E₂ in the total kidneys were significantly lower than the control values in all dietary regimens (p < 0.01). These results suggest that two-kidney one-clip renovascular hypertension in rabbits seems to be partly sodium-dependent in the chronic phase because the nonclipped kidney fails to excrete sodium sufficiently. There may also be disorders of renal prostaglandin E₂ metabolism influencing these disorders of sodium in the nonclipped kidneys.

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Section: Discussionmentioning

confidence: 99%

Role of Sodium and Renal Prostaglandin E<sub>2</sub> in the Maintenance of Hypertension in the Chronic Phase of Two-Kidney One-Clip Renovascular Hypertension in Rabbits

Machida

Ueda

Yoshida

et al. 1988

Nephron

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“…Although chronic unilateral renal artery constriction has been shown to result in functional alterations in the contralateral kidney [6,17,31], there is a paucity of data regarding the acute effects of this maneuver. Presently we observed an increase in MAP, RVR and filtration fraction after constric tion.…”

Section: Discussionmentioning

confidence: 99%

“…In chronic hy pertension resulting from unilateral renal artery constriction, the contralateral kidney exhibits increased sodium excretion [31], glomerular filtration rate (GFR) [17,31] and renal blood flow (RBF) [31]. A recent report by DeForresl ct al.…”

Section: Introductionmentioning

confidence: 99%

Contralateral Renal Function Following Unilateral Renal Artery Constriction

Murray¹,

Hackenthal²,

Mittmann³

et al. 1982

Kidney Blood Press Res

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The acute (0.5–3.0 h) response of the contralateral kidney to unilateral renal artery constriction was studied in 7 pentobarbital-anesthetized dogs. Within 30 min after unilateral renal artery constriction to a pressure of about 60 mm Hg, contralateral vascular resistance, sodium excretion and filtration fraction increased significantly while glomerular filtration rate, blood flow and plasma flow did not change. Renin secretion decreased dramatically within 30 min, demonstrating a negative venous minus arterial plasma renin activity in some dogs. Unilateral renal artery constriction did not change the rate of angiotensin II extraction across the contralateral kidney or the urinary renin activity (measured in 4 dogs). These results indicate that the acute response of the contralateral kidney to unilateral renal artery constriction is somewhat different from that seen in the chronic state.

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“…Pigs with a well-developed renal collateral circulation have higher blood pressure than those without, independently of the degree of RAS, 28 whereas in dogs, collateral development seems to reduce blood pressure. 70 However, in humans, there was no difference in the blood pressure of patients with and without collaterals, and the effect of revascularization on blood pressure was lower in patients with identifiable collaterals. 16…”

Section: Clinical and Functional Significance Of The Collateral Circu...mentioning

confidence: 97%

With a Little Help From My Friends: the Role of the Renal Collateral Circulation in Atherosclerotic Renovascular Disease

Nyvad

Lerman

2022

Hypertension

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The collateral circulation can adapt to bypass major arteries with limited flow and serves a crucial protective role in coronary, cerebral, and peripheral arterial disease. Emerging evidence indicates that the renal collateral circulation can similarly adapt and thereby limit kidney ischemia in atherosclerotic renovascular disease. These adaptations predominantly include recruitment of preexisting microvessels for arteriogenesis, with de novo vessel formation playing a limited role. Yet, adaptations of the renal collateral circulation in renovascular disease are often insufficient to fully compensate for the limited flow within an obstructed renal artery and may be hampered by the severity of obstruction or patient comorbidities. Experimental strategies have attempted to circumvent limitations of collateral formation and improve the prognosis of patients with various ischemic vascular territories. These have included pharmacological approaches such as endothelial growth factors, renin-angiotensin-aldosterone system blockade, and If-channel-blockers, as well as interventions like preconditioning, exercise, enhanced external counter-pulsation, and low-energy shock-wave therapy. However, few of these strategies have been implemented in atherosclerotic renovascular disease. This review summarizes current understanding regarding the development of renal collateral circulation in atherosclerotic renovascular disease. Studies are needed to apply lessons learned in other vascular beds in the setting of atherosclerotic renovascular disease to develop new treatment regimens for this patient group.

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The Effects of Chronic Unilateral Renal Artery Constriction on Blood Pressure, Separate Renal Function, and the Development of Collateral Circulation in the Dog

Cited by 7 publications

References 0 publications

Role of Sodium and Renal Prostaglandin E<sub>2</sub> in the Maintenance of Hypertension in the Chronic Phase of Two-Kidney One-Clip Renovascular Hypertension in Rabbits

Role of Sodium and Renal Prostaglandin E<sub>2</sub> in the Maintenance of Hypertension in the Chronic Phase of Two-Kidney One-Clip Renovascular Hypertension in Rabbits

Contralateral Renal Function Following Unilateral Renal Artery Constriction

With a Little Help From My Friends: the Role of the Renal Collateral Circulation in Atherosclerotic Renovascular Disease

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