The effects of chronic hyperlipidemia on bladder function in myocardial infarction‐prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits

Abstract

This study demonstrated that WHHLMI rabbits showed detrusor overactivity with decreased detrusor contraction. It is suggested that chronic hyperlipidemia contributes to the bladder dysfunction.

The impact of abdominal aortic calcification and visceral fat obesity on lower urinary tract symptoms in patients with benign prostatic hyperplasia

“…Moderate bladder ischemia resulted in detrusor overactivity, whereas severe bladder ischemia was associated with impaired detrusor contraction 7 . Yoshida et al reported myocardial infarction-prone Watanabe Heritable Hyperlipidemic rabbits, an animal model for human familial 8 hypercholesterolemia and atherosclerosis, showed detrusor overactivity with decreased detrusor contraction 8 . Another study using the rat model of atherosclerosis-induced chronic bladder ischemia showed that reduction in BBF was associated with detrusor overactivity and urinary frequency 9 , and that the levels of oxidative stress markers and proinflammatory cytokines were increased in rats with chronic bladder ischemia 10 .…”

Lower Urinary Tract Symptoms and Aging: The Impact of Chronic Bladder Ischemia on Overactive Bladder Syndrome

“…Yoshida et al [37] , using a Watanabe heritable hyperlipidemic rabbit model, observed significant atherosclerosis of the internal iliac arteries, a thickening of their media and several cystometric changes towards detrusor overactivity, indicating a correlation between bladder dysfunction and hyperlipidemia.…”

“…Numerous animal models have been developed in order to investigate the association between ischemia and bladder dysfunction using mice, rats and rabbits [36][37][38][39][40][41][42][43][44][45][46][47][48] .…”

Pathophysiology and Animal Modeling of Underactive Bladder

“…Among Americans 65 years and older, more than one-half have been diagnosed with three or more chronic conditions [13]. Common chronic conditions such as diabetes mellitus are known to predispose individuals to UAB, while animal studies discussed below indicate that chronic ischemia commonly seen in the context of atherosclerosis and microvascular disease [14], a profound lack of estrogen seen in some postmenopausal women [15][16][17][18] or biological processes, which are intrinsic to aging [17,19] could also potentially contribute to UAB by favoring the development of degenerative or biochemical changes involving key components of the detrusor muscle, its contractile machinery or its innervation. For example, there is a striking paucity of studies that would permit an examination of the relationship between menopause or estrogen status and UAB or DU.…”