The Effects of Chronic Ethanol Consumption During Early Pregnancy on Conceptus Health and Uterine Function in Pigs

Kubotsu, Stephanie L.; Hu, Jianbo; Carnahan, Kevin G.; Deavila, Jeanene M; Ott, Troy L.; Mirando, Mark A.

doi:10.1111/j.1530-0277.2003.tb04409.x

Cited by 8 publications

(2 citation statements)

References 36 publications

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“…Thus, one may conclude from these results that the elevated PGFM observed in response to ethanol in was not of endometrial origin and therefore not capable of inducing luteolysis. This conclusion is supported by Kubotsu et al. (2003), which reported that ethanol intake at day 16 of pregnancy actually decreased PGF2α secretion by swine endometrium.…”

Section: Discussionmentioning

confidence: 54%

Effects of Ethanol on Synthesis of Prostaglandin F2α in Bovine Females

Barros

Bertan

Dias

et al. 2009

Reproduction in Domestic Animals

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Ethanol stimulates the production of prostaglandins in many species. The purpose of this study was to verify the effect of ethanol on the production of prostaglandin F2α (PGF2α) and luteolysis in bovine females. In the first experiment, Holstein cows at day 17 of the oestrous cycle were treated with 100% ethanol (0.05 ml/kg of body weight, IV; n = 5), saline (0.05 ml/kg of body weight, IV; n = 4) or synthetic prostaglandin (150 μg of D-cloprostenol/cow, IM; n = 4). The plasma concentrations of 13, 14-dihydro-15-keto PGF2α (PGFM; the main metabolite of PGF2α measured in the peripheral blood) were assessed by radioimmunoassay (RIA). There was an acute release of PGFM in response to ethanol comparing to other treatments (p ≤ 0.05). However, only cows treated with PGF2α underwent luteolysis. In the second experiment, endometrial explants of cross-bred beef cows (n = 4) slaughtered at day 17 of the oestrous cycle were cultured for 4 h. During the last 3 h, the explants were cultured with medium supplemented with 0, 0.1, 1, 10 or 100 μl of 100% ethanol/ml. Medium samples were collected at hours 1 and 4 and concentrations of PGF2α were measured by RIA. Ethanol did not induce PGF2α production by the endometrium. In conclusion, ethanol does not cause luteolysis in cows because it stimulates production of PGF2α in extra-endometrial tissues.

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Section: Discussionmentioning

confidence: 54%

Effects of Ethanol on Synthesis of Prostaglandin F2α in Bovine Females

Barros

Bertan

Dias

et al. 2009

Reproduction in Domestic Animals

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“…Alcohol added to food [3][4][5][6] still does not persuade large animals to consume the entire ration [7], as they avoid food with high alcohol concentrations [8], absorption is reduced [9], and special nutritional schemes are required to avoid nutritional deficiency [4,10]. Intravenous infusion of ethanol has been used only for short experiments with durations in the range of hours and this is not truly analogous to ethanol absorption in humans.…”

Section: Introductionmentioning

confidence: 99%

Percutaneous Intragastric Catheter (PIC) for Administration of an Unpalatable Substance to Large Animals

Oleszczuk

Spannbauer

Blüher

et al. 2009

Journal of Investigative Surgery

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We studied an easy and reliable technique for administration of an unpalatable substance to large animals. There were three groups of pigs: group I (n = 6) received 1 g ethanol/kg body weight per day orally with water for 24 days, group II (n = 6) received 2 g ethanol/kg orally with water for 24 days and 4 g ethanol/kg via percutaneous intragastric catheter (PIC) for the next 24 days, group III (n = 6) received 6 g ethanol/kg via PIC for 72 days. The catheter was placed after insufflation of the stomach using an orogastric tube. PIC was successfully placed in each pig. No complications occurred during placement. The total amount of the administrated dose was assimilated each time. PIC is a safe, effective, well tolerated, and precise method of administering ethanol that is inexpensive and easy to perform. Ethanol administration via PIC is a convenient and effective mean of exposing animals to high levels of alcohol on a long-term basis.

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Animal Models for Studying Fetal Alcohol Syndrome, Alcohol-Related Birth Defects, and Alcohol-Related Neurodevelopmental Disorder

Cudd

Sourcebook of Models for Biomedical Research

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The Effects of Chronic Ethanol Consumption During Early Pregnancy on Conceptus Health and Uterine Function in Pigs

Abstract: These results indicate that chronic ethanol consumption may impair conceptus health directly or indirectly through actions upon the endometrium. Thus, the pig may be a valuable experimental model for studies on the effects of maternal alcohol consumption on conceptus development.

Cited by 8 publications

References 36 publications

Effects of Ethanol on Synthesis of Prostaglandin F2α in Bovine Females

Effects of Ethanol on Synthesis of Prostaglandin F2α in Bovine Females

Percutaneous Intragastric Catheter (PIC) for Administration of an Unpalatable Substance to Large Animals

Animal Models for Studying Fetal Alcohol Syndrome, Alcohol-Related Birth Defects, and Alcohol-Related Neurodevelopmental Disorder

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