The Effects of Childhood Cancer and Its Treatment on Two Objective Measures of Psychological..

Butler, Robert W.; Rizzi, Lisa P.; Bandilla, Erin B.

doi:10.1207/s15326888chc2804_3

Cited by 12 publications

(11 citation statements)

References 23 publications

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“…Younger age at diagnosis and being female became recognized as major risk factors for greater impairment among children treated for ALL or a brain tumor [Meadows et al, 1981;Robison et al, 1984;Ellenberg et al, 1987;Mulhern et al, 1987Mulhern et al, , 1992Jannoun and Bloom, 1990;Waber et al, 1990;Butler et al, 1994]. Both of these findings were replicated by later studies [Butler et al,1999;Leung et al, 2000;von der Weid et al, 2003].…”

Section: Brain Tumorsmentioning

confidence: 91%

Neurocognitive effects of treatment for childhood cancer

Butler

Haser

2006

Ment. Retard. Dev. Disabil. Res. Rev.

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170

137

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We review research on the neuropsychological effects that central nervous system (CNS) cancer treatments have on the cognitive abilities of children and adolescents. The authors focus on the two most common malignancies of childhood: leukemias and brain tumors. The literature review is structured so as to separate out earlier studies, generally those published prior to 1995, as opposed to manuscripts that have been published within the past decade. This is an important distinction for both leukemia and brain tumors. Earlier studies were ground breaking in that they began to map out what could be expected in terms of intelligence and academic problems in survivors of pediatric malignancies. Survivorship in this population has and continues to markedly increase and this is largely due to changes in treatment protocols. Research on neurocognitive effects of disease and treatment in pediatric oncology has become increasingly sophisticated, and this literature review not only reflects this trend, but highlights the growing collaboration between neuropsychology, cognitive neuroscience, and neuro-imaging. Thus, our goal was to provide a historical foundation, lead the reader towards the progression of research methodology up to the current state of the art, and perhaps most importantly, discuss future directions. These directions are especially relevant to the concepts of remediation and treatment of cognitive problems, and this is emphasized at the conclusion of the review.

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Section: Brain Tumorsmentioning

confidence: 91%

Neurocognitive effects of treatment for childhood cancer

Butler

Haser

2006

Ment. Retard. Dev. Disabil. Res. Rev.

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170

137

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“…Several excellent reviews are available supporting this approach to understanding neurocognitive deficits among children surviving ALL and brain tumours, which suggest that children surviving brain tumours are at greater risk for more severe deficits because of the increased aggressiveness of their therapy and, in particular, the continued use of CRT [4][5][6]. These reviews and more recent studies have further emphasized that the severity of deficits is also dependent upon patient age and gender, with girls and younger patients being more vulnerable [7][8][9][10].…”

Section: Neurocognitive Late Effectsmentioning

confidence: 99%

ReviewNeurocognitive sequelae of childhood cancers and their treatment

Mulhern

Butler

2004

Pediatric Rehabilitation

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133

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The present review will focus on the neurocognitive aspects of the medical treatment of childhood cancer by discussing current knowledge of brain damage among patients and how it is reflected in their cognitive abilities. It will direct these efforts toward the two most common forms of childhood cancer, acute lymphoblastic leukaemia (ALL) and brain tumours. It will first provide the reader with a brief medical background followed by a review of the current literature. The literature review will provide an in-depth analysis of the types of cognitive impairments observed and known or suspected risk factors for impairments. Finally, the review will close with a section that discusses interventions with the potential to prevent or minimize cognitive deficits acquired in the course of cancer treatment as they impact on the quality of life of paediatric cancer survivors.

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“…Children at higher risk for cognitive sequelae include those younger than 6 to 8 years, particularly girls (Butler, Rizzi, & Bandilla, 1999;Gamis & Nesbit, 1991;Leung et al, 2000;Palmer et al, 2001;Ris, Packer, Goldwein, Jones-Wallace, & Boyett, 2001); those who received central nervous system radiation (Gamis & Nesbit, 1991;Lockwood, Bell, & Colegrove, 1999); and those with a combination of these 2 factors. In addition, children receiving concurrent intrathecal methotrexate or high-dose intravenous methotrexate and those with computerized axial tomography scan abnormalities have additional risk factors for cognitive sequelae (Gamis & Nesbit, 1991).…”

Section: Neurocognitive Deficitsmentioning

confidence: 99%

The Role of Cognitive Remediation in Childhood Cancer Survivors Experiencing Neurocognitive Late Effects

Spencer¹

2006

J Pediatr Oncol Nurs

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With the increasing number of children becoming long-term cancer survivors, it has become evident that these survivors are experiencing long-term neurocognitive deficits. Many of these deficits have been found to be the result of cancer-related therapies including intravenous and intrathecal chemotherapy and cranial radiation. These neurocognitive deficits include learning disabilities, cognitive deficits, attention disorders, and difficulties with memory. Cognitive remediation therapy uses a systematic approach to learning strategies that is aimed to equip these affected children with proper, effective, and proven learning strategies. This article will briefly discuss the neurocognitive deficits experienced by long-term childhood cancer survivors. Cognitive remediation therapy will then be introduced with specific attention to the cognitive remediation program developed by Butler and Copeland. Finally, implications for practice and future research will be discussed.

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The Effects of Childhood Cancer and Its Treatment on Two Objective Measures of Psychological..

Cited by 12 publications

References 23 publications

Neurocognitive effects of treatment for childhood cancer

Neurocognitive effects of treatment for childhood cancer

ReviewNeurocognitive sequelae of childhood cancers and their treatment

The Role of Cognitive Remediation in Childhood Cancer Survivors Experiencing Neurocognitive Late Effects

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