The effects of cetirizine on the adhesion of human eosinophils and neutrophils to cultured human umbilical vein endothelial cells

Kyan-Aung, U; Hallsworth, Matthew P.; Haskard, Dorian O.; Vos, Christine De; Lee, Tak H.

doi:10.1016/0091-6749(92)90083-e

Cited by 36 publications

(23 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a relevant conclusion can be drawn from this observation: ICAM-1 expression on epithelial cells is likely to be inhibited by CTR through a mechanism other than its anti-H, activity, since we found that histamine cannot induce lCAM-1 expression (17). These in vivo findings provide further insights into CTR "antiallergic" effects, since KyanAung et al (38) previously demonstrated that CTR, in vitro, inhibits adhesion of both eosinophils and neutrophils to the endothelium. Studies are presently in progress on the possible effects of other anti-H i drugs such as mizolastine, oxatoniide, and terfenadine.…”

Section: Am and Allergic Disease Treatmentmentioning

confidence: 63%

Adhesion molecules of allergic inflammation: recent insights into their functional roles

Canonica

Ciprandi

Buscaglia

et al. 1994

Allergy

View full text Add to dashboard Cite

show abstract

Section: Am and Allergic Disease Treatmentmentioning

confidence: 63%

Adhesion molecules of allergic inflammation: recent insights into their functional roles

Canonica

Ciprandi

Buscaglia

et al. 1994

Allergy

View full text Add to dashboard Cite

show abstract

“…Thus, our data provide evidence that cetirizine exerts anti-inflammatory activities apart from the antagonism of H,-receptors and may provide the basis to extend the therapeutical range of cetirizine [18].…”

Section: Discussionmentioning

confidence: 92%

“…Furthermore, it has been demonstrated that cetirizine inhibits the adhesion of eosinophils after cellular activation via the G-protein-couplcd fMLP receptor [18].…”

Section: Discussionmentioning

confidence: 99%

Cetirizine Exerts Anti-Inflammatory Effects on Human Neutrophils

Köller

Hilger²,

Rihoux³

et al. 1996

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Leukotrienes are potent lipid mediators involved in acute and chronic inflammatory processes and allergic inflammation. Cetirizine is an H₁-receptor antagonist used in the treatment of allergic symptoms. We analyzed the effect of cetirizine on the formation of leukotriene B₄ (LTB₄) after stimulation of human peripheral blood neutrophils. The inflammatory mediators were analyzed after cellular activation with different stimuli: the Ca ionophore A23187, which bypasses membranous signal transduction elements; the bacterial peptide formyl-methionine-leucyl-phenylalonine (fMLP), which activates cells by binding to a GTP-protein (G-protein)-coupled receptor, and with sodium fluoride (NaF), which directly activates G-proteins. After cellular preincubation with cetirizine, the amounts of LTB₄ generated from neutrophil granulocytes decreased significantly when the cells were subsequently stimulated with either fMLP or NaF, in contrast to stimulations with the Ca ionophore. The data provide evidence that cetirizine exerts anti-inflammatory effects apart from H₁ antagonism.

show abstract

“…In addition to its anti-H1-receptor properties, cetirizine possesses inhibitory properties for basophils [511], and eosinophils [512][513][514]. For instance, cetirizine has been shown to inhibit chemotaxis of eosinophils in vivo [512,513,515], and in vitro [514], reduces both PAF-induced receptor complement expression and cytotoxicity [516], prevents IL-5-induced ICAM-1 expression in vitro [517], and selectively blocks adhesion of eosinophil to endothelial cells [518] possibly via the very late activation antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) interaction.…”

Section: Xanthines and Selective Phosphodiesterase Inhibitorsmentioning

confidence: 99%

Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part II)

Kroegel¹,

Warner²,

Jc³

et al. 1994

Eur Respir J

View full text Add to dashboard Cite

The second part of this review on eosinophils focuses on biological cell functions and surveys the various deleterious mechanisms involved in the eosinophil-dominated inflammatory reaction. It discusses the possible pathogenic role of eosinophils in several eosinophil-related diseases, such as parasitic infections, interstitial lung disorders and bronchial diseases, graft rejection, vasculitic granulomatous disorders, pleural effusion, and bronchogenic tumours.The final section of the article highlights the possible recent pharmacological and future therapeutic approaches in modifying eosinophil recruitment and function. Eur Respir J., 1994, 7, 743-760 This paper is published as a follow-on to "Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part I)"* (Eur Respir J, 1994; 7: 519-543). Biological cell functionsThe eosinophil mediates its effector functions through various distinct cellular mechanisms, namely nonoxidative, oxidative, and humoral mechanisms ( fig. 7). Nonoxidative mechanismsAs mentioned previously, the three basic proteins as well as eosinophil peroxidase (EPO) have toxic properties independent of molecular oxygen species. For instance, major basic protein (MBP) [323], eosinophil cationic protein (ECP) [324] and EPO in the presence of hydrogen superoxide and a halide [99] kill helminthic parasites in vitro. In addition, these proteins are toxic for tumour cells and/or mammalian cells [325], including human pulmonary parenchyma and interstitial matrix [326,327], cultured human lung epithelial cells [328], and guinea-pig respiratory epithelium [252, 253,329]. Furthermore, it has been demonstrated that MBP damages human bronchial epithelium, which consists of desquamation and destruction of ciliated cells [329]. Finally, release of their granule proteins by plateletactivating factor (PAF)-activated intact eosinophils has been shown to imitate the characteristic pathological findings of airway epithelium in asthma [330].In addition to their cytotoxic action, eosinophil cationic proteins at certain subtoxic concentrations also stimulate other inflammatory cells. For instance, MBP and ECP have been shown to degranulate platelets [305], induce histamine release from mast cells and basophils [240, 245,331], as well as superoxide anion generation and lysosomal enzyme release by human neutrophils [264].Finally, eosinophil proteins may affect airway muscle function and hyperresponsiveness. Recent reports investigating the effects of direct intratracheal instillation of purified eosinophil granule proteins on pulmonary function and airway responsiveness in primates [281,332] have shown that MBP induces a dose-related increase in airway responsiveness to inhaled methacholine. In the same model, both MBP and EPO caused a transient bronchoconstriction immediately after instillation, that resolved within 1 h. Interestingly, other eosinophil granular proteins failed to effect airway responsiveness or pulmonary function.Mode of action. The mode of action of these basic proteins is n...

show abstract

The effects of cetirizine on the adhesion of human eosinophils and neutrophils to cultured human umbilical vein endothelial cells

Cited by 36 publications

References 7 publications

Adhesion molecules of allergic inflammation: recent insights into their functional roles

Adhesion molecules of allergic inflammation: recent insights into their functional roles

Cetirizine Exerts Anti-Inflammatory Effects on Human Neutrophils

Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part II)

Contact Info

Product

Resources

About