The effects of ceftriaxone by intravenous push on adverse drug reactions in the emergency department

Agunbiade, Abdulkareem; Routsolias, Joanne C.; Rizvanolli, Lum; Bleifuss, Will; Sundaresan, Sharadram; Moskoff, Jordan

doi:10.1016/j.ajem.2020.03.022

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…Ceftriaxone-induced intestinal dysbacteriosis is a focus of research and a growing health concern [ 63 ]. In terms of application, ceftriaxone can be administrated via intraperitoneal injection [ 64 ], gavage [ 21 ], subcutaneous injection [ 65 ], intravenous injection [ 66 ], aerosol inhalation delivery [ 67 ], and intramuscular injection [ 68 ], among which intravenous injection and intramuscular injection are two typical administration methods in clinical treatment. In this study, we adopted gavage administration referring to the practice of many researchers who administered ceftriaxone orally to mouse models [ 21 – 23 ].…”

Section: Resultsmentioning

confidence: 99%

Short-term exposure to antibiotics begets long-term disturbance in gut microbial metabolism and molecular ecological networks

Hong,

Li,

Chen

et al. 2024

Microbiome

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Background Antibiotic exposure can occur in medical settings and from environmental sources. Long-term effects of brief antibiotic exposure in early life are largely unknown. Results Post a short-term treatment by ceftriaxone to C57BL/6 mice in early life, a 14-month observation was performed using 16S rRNA gene-sequencing technique, metabolomics analysis, and metagenomics analysis on the effects of ceftriaxone exposure. Firstly, the results showed that antibiotic pre-treatment significantly disturbed gut microbial α and β diversities (P < 0.05). Both Chao1 indices and Shannon indices manifested recovery trends over time, but they didn’t entirely recover to the baseline of control throughout the experiment. Secondly, antibiotic pre-treatment reduced the complexity of gut molecular ecological networks (MENs). Various network parameters were affected and manifested recovery trends over time with different degrees, such as nodes (P < 0.001, R2 = 0.6563), links (P < 0.01, R2 = 0.4543), number of modules (P = 0.0672, R2 = 0.2523), relative modularity (P = 0.6714, R2 = 0.0155), number of keystones (P = 0.1003, R2 = 0.2090), robustness_random (P = 0.79, R2 = 0.0063), and vulnerability (P = 0.0528, R2 = 0.28). The network parameters didn't entirely recover. Antibiotic exposure obviously reduced the number of key species in gut MENs. Interestingly, new keystones appeared during the recovery process of network complexity. Changes in network stability might be caused by variations in network complexity, which supports the ecological theory that complexity begets stability. Besides, the metabolism profiles of the antibiotic group and control were significantly different. Correlation analysis showed that antibiotic-induced differences in gut microbial metabolism were related to MEN changes. Antibiotic exposure also caused long-term effects on gut microbial functional networks in mice. Conclusions These results suggest that short-term antibiotic exposure in early life will cause long-term negative impacts on gut microbial diversity, MENs, and microbial metabolism. Therefore, great concern should be raised about children’s brief exposure to antibiotics if the results observed in mice are applicable to humans.

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Section: Resultsmentioning

confidence: 99%

Short-term exposure to antibiotics begets long-term disturbance in gut microbial metabolism and molecular ecological networks

Hong,

Li,

Chen

et al. 2024

Microbiome

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“…Logo, os estudos elegíveis apresentaram alguns dos principais eventos adversos da utilização da ceftriaxona na prática clínica. 14 As cefalosporinas têm a capacidade de sensibilizar o indivíduo e podem desencadear uma variedade de reações de hipersensibilidade que são idênticas às das penicilinas incluindo anafilaxia, febre, erupções cutâneas, nefrite e anemia hemolítica. A irritação local pode produzir dor intensa após injeção intramuscular e tromboflebite após injeção intravenosa.…”

Section: Discussõesunclassified

A ocorrência de eventos adversos com uso de Ceftriaxona

Zanoni¹,

Toqueton²,

Gasques³

et al. 2023

Braz. J. Hea. Rev.

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Cada vez mais as substâncias sintéticas têm ganhado espaço como antimicrobiano e consequentemente tem sido lançado na indústria farmacêutica, o que inclui a ceftriaxona. A alta utilização desses medicamentos tem constituído um problema de saúde pública global, visto que, também são considerados substâncias químicas que mais causam eventos adversos. O principal objetivo do presente estudo é abordar através da presente revisão sistematizada os principais eventos adversos decorrentes do uso de ceftriaxona na prática clínica. Trata-se de uma revisão sistemática, dos quais, foram realizadas buscas na PubMed, Periódico Capes e na Biblioteca Virtual em Saúde (BVS), com os principais Descritores e palavras-chave: “Ceftriaxone” AND “Drug-Related Side Effects and Adverse” AND Reactions, contanto com uma totalidade de 8 estudos para análise. Logo, os estudos abordam que os eventos adversos relacionados a utilização da ceftriaxona em sua maioria das vezes, foram ocasionados pelo uso não apropriado do medicamento pelos profissionais de saúde, além de condições médicas não apropriadas, tendo como menores abordagens a baixa qualidade do medicamento. Assim, é fundamental o compreendimento que mesmo a ceftriaxona apresentando eventos adversos, desde leves até mesmo raros, os riscos podem ser de alguma forma evitados, sobretudo, no que diz respeito a um protocolo e administração do medicamento adequadamente.

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Antibiotics Administered via Intravenous Push Versus Intravenous Piggyback to Adult Patients in the Emergency Department: a Randomized Trial

Rahbar

Promlap

Patel

et al. 2023

SN Compr. Clin. Med.

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The effects of ceftriaxone by intravenous push on adverse drug reactions in the emergency department

Cited by 6 publications

References 9 publications

Short-term exposure to antibiotics begets long-term disturbance in gut microbial metabolism and molecular ecological networks

Short-term exposure to antibiotics begets long-term disturbance in gut microbial metabolism and molecular ecological networks

A ocorrência de eventos adversos com uso de Ceftriaxona

Antibiotics Administered via Intravenous Push Versus Intravenous Piggyback to Adult Patients in the Emergency Department: a Randomized Trial

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