The effects of carotid sinus baroreceptor reflexes on pulmonary arterial pressure and pulmonary blood flow in the dog

Daly, M. de Burgh; Lück, Christian

doi:10.1113/jphysiol.1958.sp006064

Cited by 24 publications

(21 citation statements)

References 36 publications

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“…Several authors (Leusen, Demeester & De Witte, 1954;Daly & Luck, 1958) have produced evidence for a rise in cardiac output when sinus pressure is reduced, but others (Polosa & Rossi, 1961 ;Groom, Ldfving, Rowlands & Thomas, 1962;Corcondilas, Donald & Shepherd,' 1964) (Ginsburg & Duncan, 1967); indeed, Raynaud (1862) himself described how a patient of his enjoyed amelioration of her vasospasm when she was pregnant. A smaller rise of flow occurs in the kidney (Chesley, 1960).…”

Section: Resultsmentioning

confidence: 99%

The carotid sinus baroreceptor reflex in the pregnant rabbit

Humphreys¹,

Joels²

1974

The Journal of Physiology

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SUMMARY1. The reflex responses to baroreceptor stimulation have been compared in eight pregnant and eight non-pregnant anaesthetized female rabbits.2. The vascularly isolated, innervated carotid sinus was exposed for 30 sec to a series of non-pulsatile pressures ranging from 30 to 230 mmHg. The contralateral sinus nerve and both aortic nerves were cut. Systemic arterial pressure and heart rate were measured at each sinus pressure.3. The range of arterial pressure change which could be evoked from the isolated innervated sinus was less in the pregnant than in the non-pregnant rabbits. Mean changes were 98 and 61 mmHg respectively. On the other hand changes in heart rate were similar in the two groups (45 and 43 beats/ min respectively).4. The smaller blood pressure response in the pregnant animals resulted from a lesser rise in systemic arterial pressure at low levels of sinus pressure. At high sinus pressures the blood pressure fell to a similar level in both groups of animals.5. Pressure on the great vessels by the gravid uterus was not a factor since there was no consistent difference between the responses obtained with the rabbit lying on its back or on its side.6. Mechanisms which might be responsible for the difference found are discussed.

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Section: Resultsmentioning

confidence: 99%

The carotid sinus baroreceptor reflex in the pregnant rabbit

Humphreys¹,

Joels²

1974

The Journal of Physiology

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“…However, since no measurements of peripheral venous pressure were carried out, this explanation must be considered to be speculative. Furthermore, it is now clear from the experiments of Daly and Luck (26) and of Sarnoff and co-workers (27) that carotid sinus stimulation depresses ventricular function strikingly and thereby diminishes the external work performed by the ventricle from any given filling pressure. In addition, the latter workers have also shown that baroreceptor stimulation depresses atrial contractility.…”

Section: Discussionmentioning

confidence: 99%

Studies on Starling's Law of the Heart. I. The Circulatory Response to Acute Hypervolemia and Its Modification by Ganglionic Blockade

Frye¹,

Braunwald²,

Cohen³

1960

J. Clin. Invest.

110

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“…Arterial pressure is determined by both cardiac output and peripheral resistance and while the participation in this reflex of alterations in P. W. HUMPHREYS AND N. JOELS the calibre of resistance vessels in muscle, skin and splanchnic beds is well established (Heymans & Neil, 1958), there have been only a few reports covering the possible contribution to the response of changes in cardiac output. Daly & Luck (1958) raised the pressure within the isolated sinus of the dog by up to 140 mmHg and found an average reduction of 17*6 % in combined superior and inferior caval flow. A similar fall in cardiac output, of about 15%, was noted by Schmidt, Kumada & Sagawa (1971) when sinus pressure was raised between 50 and 200 mmHg in dogs with vagi intact, but after vagotomy, to eliminate secondary effects from aortic baroreceptors as well as vagal effects on heart rate, the same change in sinus pressure reduced cardiac output by about 60 %.…”

Section: Introductionmentioning

confidence: 99%

The contribution of alterations in cardiac output to changes in arterial pressure reflexly evoked from the carotid sinus in the rabbit.

Humphreys¹,

Joels²

1977

The Journal of Physiology

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SUMMARY1. The reflex cardiovascular effects of changes in pressure within the vascularly isolated carotid sinus were examined in seventeen anaesthetized rabbits. The opposite sinus was denervated and both aortic nerves were divided.2. Comparison ofthe mean values at sinus pressures of 40 and 200 mmHg showed a large reduction in systemic arterial pressure from 126 to 58 mmHg and a moderate reduction in heart rate, from 287 to 253 beats min-'. Cardiac output, measured by thermal dilution, showed only a small change, a fall from 160 to 148 ml. min-kg-'.3. By contrast with this reduction in cardiac output of just over 7 %, total peripheral resistance, derived by dividing mean arterial pressure by cardiac output, was halved, falling from 0-84 to 0-41 mmHg ml.-' min kg. 4. Thus in the anaesthetized rabbit changes in cardiac ouput make only a small contribution to the changes in systemic pressure evoked by alterations in carotid sinus pressure. Changes in total peripheral resistance are principally responsible for the effect on systemic pressure.5. Though the changes in output of the heart were small, there were considerable changes in the work done by the left ventricle which was approximately halved when carotid sinus pressure was raised from 40 to 200 mmHg.

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The effects of carotid sinus baroreceptor reflexes on pulmonary arterial pressure and pulmonary blood flow in the dog

Cited by 24 publications

References 36 publications

The carotid sinus baroreceptor reflex in the pregnant rabbit

The carotid sinus baroreceptor reflex in the pregnant rabbit

Studies on Starling's Law of the Heart. I. The Circulatory Response to Acute Hypervolemia and Its Modification by Ganglionic Blockade

The contribution of alterations in cardiac output to changes in arterial pressure reflexly evoked from the carotid sinus in the rabbit.

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