The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of <i>In Vivo</i> Studies

Henshaw, Frances R; Dewsbury, L.S.; Lim, Chai K.; Steiner, Genevieve Z.

doi:10.1089/can.2020.0105

Cited by 79 publications

(55 citation statements)

References 75 publications

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“…In a murine asthma model, intraperitoneal CBD administration attenuated inflammatory cytokine increase associated with aerosol challenge 12. This result is echoed in many other studies 13…”

Section: How MC Might Help: Cancer Inflammation and Treatment Responsesupporting

confidence: 53%

Research agenda for medical cannabis in palliative care

Gurgenci

Hardy

Good

2022

BMJ Support Palliat Care

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“…In a murine asthma model, intraperitoneal CBD administration attenuated inflammatory cytokine increase associated with aerosol challenge 12. This result is echoed in many other studies 13…”

Section: How MC Might Help: Cancer Inflammation and Treatment Responsesupporting

confidence: 53%

Research agenda for medical cannabis in palliative care

Gurgenci

Hardy

Good

2022

BMJ Support Palliat Care

View full text Add to dashboard Cite

“…Conversely, CB2 receptors are mainly involved in regulating inflammation by modulating the levels of various cytokines [41]. A recent systematic review of in vivo studies regarding the anti-inflammatory effects of various cannabinoids concluded that the CB2 antagonist CBD is efficient in reducing inflammation, while CB1 agonists-such as THC-may be used for the alleviation of the associated pain [42].…”

Section: Cannabinoids and Inflammationmentioning

confidence: 99%

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

Scheau

Căruntu

Bădărău

et al. 2021

JPM

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Recent studies have identified great similarities and interferences between the epithelial layers of the digestive tract, the airways and the cutaneous layer. The relationship between these structures seems to implicate signaling pathways, cellular components and metabolic features, and has led to the definition of a gut-lung-skin barrier. Inflammation seems to involve common features in these tissues; therefore, analyzing the similarities and differences in the modulation of its biomarkers can yield significant data promoting a better understanding of the particularities of specific signaling pathways and cellular effects. Cannabinoids are well known for a wide array of beneficial effects, including anti-inflammatory properties. This paper aims to explore the effects of natural and synthetic cannabinoids, including the components of the endocannabinoid system, in relation to the inflammation of the gut-lung-skin barrier epithelia. Recent advancements in the use of cannabinoids as anti-inflammatory substances in various disorders of the gut, lungs and skin are detailed. Some studies have reported mixed or controversial results, and these have also been addressed in our paper.

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“…Moreover, they have indicated that the combination of cannabinoids, namely CBD+CBG, and CBD+THC can show the most effective anti-inflammatory effect in vivo . This information may be essential in the further human clinical trials of cannabinoids based on using CBD and CBG as the inhibitors of inflammation across a range of pathophysiological processes ( 66 ).…”

Section: Ecs Role In Maintaining Immune System Homeostasismentioning

confidence: 99%

Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease – A Systematic Review

et al. 2021

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Inflammatory bowel disease (IBD) is a general term used to describe a group of chronic inflammatory conditions of the gastrointestinal tract of unknown etiology, including two primary forms: Crohn’s disease (CD) and ulcerative colitis (UC). The endocannabinoid system (ECS) plays an important role in modulating many physiological processes including intestinal homeostasis, modulation of gastrointestinal motility, visceral sensation, or immunomodulation of inflammation in IBD. It consists of cannabinoid receptors (CB1 and CB2), transporters for cellular uptake of endocannabinoid ligands, endogenous bioactive lipids (Anandamide and 2-arachidonoylglycerol), and the enzymes responsible for their synthesis and degradation (fatty acid amide hydrolase and monoacylglycerol lipase), the manipulation of which through agonists and antagonists of the system, shows a potential therapeutic role for ECS in inflammatory bowel disease. This review summarizes the role of ECS components on intestinal inflammation, suggesting the advantages of cannabinoid-based therapies in inflammatory bowel disease.

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The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of In Vivo Studies

Cited by 79 publications

References 75 publications

Research agenda for medical cannabis in palliative care

Research agenda for medical cannabis in palliative care

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease – A Systematic Review

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