The Effects of Caffeine on Simulated Night-Shift Work and Subsequent Daytime Sleep

Muehlbach, Mark J.; Walsh, James K.

doi:10.1093/sleep/18.1.22

Cited by 98 publications

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“…Caffeine during a night shift, for example, has been demonstrated to improve performance (Walsh et al, 1990), increase ratings of alertness, and decrease physiological measures of sleep during work hours without altering daytime sleep (Muehlbach and Walsh, 1995). In addition, we reported that methamphetamine attenuated night-shift-related performance impairments and even improved performance on some measures that were not disrupted as a function of the night-shift condition (Hart et al, 2003a).…”

Section: Introductionmentioning

confidence: 73%

Modafinil Attenuates Disruptions in Cognitive Performance During Simulated Night-Shift Work

Hart

Haney

Vosburg

et al. 2005

Neuropsychopharmacol

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Common complaints among shift workers are sleep disruptions and increased sleepiness while working, which may contribute to shift workers being more susceptible to diminished performance and work-related accidents. The purpose of this double-blind, withinparticipant study was to examine the effects of the alerting agent modafinil on cognitive/psychomotor performance, mood, and measures of sleep during simulated shift work. In all, 11 participants completed this 23-day residential laboratory study. They received a single oral modafinil dose (0, 200, 400 mg) 1 h after waking for three consecutive days under two shift conditions: day shift and night shift. Shifts alternated three times during the study, and shift conditions were separated by an 'off' day. When participants received placebo, cognitive performance and subjective ratings of mood were disrupted during the night shift, relative to the day shift. Objective and subjective measures of sleep were also disrupted, but to a lesser extent. Modafinil reversed disruptions in cognitive performance and mood during the night shift. While modafinil produced few effects on sleep measures during the night shift, the largest dose produced several sleep alterations during the day shift. These data demonstrate that abrupt shift changes produced cognitive performance impairments and mood disruptions during night shift work. Therapeutic doses of modafinil attenuated night-shift-associated disruptions, but the larger dose produced some sleep impairments when administered during day-shift work.

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Section: Introductionmentioning

confidence: 73%

Modafinil Attenuates Disruptions in Cognitive Performance During Simulated Night-Shift Work

Hart

Haney

Vosburg

et al. 2005

Neuropsychopharmacol

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“…Using quantitative sleep electroencephalogram (EEG), a recent study by Landolt et al (2004) has shown that the administration of two doses of caffeine during a 40-h sleep deprivation significantly reduces EEG power in the 0.75-2.0 Hz band and enhances power in the 11.25-20.0 Hz range relative to placebo during recovery night. Only two human studies have evaluated the effects of caffeine on daytime recovery sleep following one night of sleep deprivation (LaJambe et al, 2005;Muehlbach and Walsh, 1995). In one study, no effect of caffeine on daytime recovery sleep was found (Muehlbach and Walsh, 1995), while in the other study caffeine reduced SWS and sleep duration, and increased wakefulness during recovery sleep (LaJambe et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Only two human studies have evaluated the effects of caffeine on daytime recovery sleep following one night of sleep deprivation (LaJambe et al, 2005;Muehlbach and Walsh, 1995). In one study, no effect of caffeine on daytime recovery sleep was found (Muehlbach and Walsh, 1995), while in the other study caffeine reduced SWS and sleep duration, and increased wakefulness during recovery sleep (LaJambe et al, 2005). These conflicting results may be explained by different caffeine levels in the body at bedtime, since in the first study caffeine was administered more than 8 h before daytime recovery sleep, while in the second study the last dose of caffeine was taken 2 h before sleep.…”

Section: Introductionmentioning

confidence: 99%

Effects of Caffeine are more Marked on Daytime Recovery Sleep than on Nocturnal Sleep

Carrier

Fernandez‐Bolaños

Robillard

et al. 2006

Neuropsychopharmacol

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Caffeine is often used to counteract sleepiness generated by sleep deprivation, jet lag, and shift-work, and is consumed at different times of day. Caffeine also has effects on sleep. However, little is known about the interaction between sleep deprivation, circadian timing, and caffeine consumption on sleep. In this study, we compared the effects of caffeine on nocturnal sleep initiated at habitual circadian time and on daytime recovery sleep. Thirty-four moderate caffeine consumers participated in both caffeine (200 mg) and placebo (lactose) conditions in a double-blind crossover design. Seventeen subjects followed their habitual sleep-wake cycle and slept in the laboratory during the night (Night), while 17 subjects were sleep deprived for one night and recovery sleep started in the morning (DayRec). All subjects received a capsule of 100 mg of caffeine (or placebo) 3 h before bedtime, and the remaining dose 1 h before bedtime. Compared to placebo, caffeine lengthened sleep latency, increased stage 1, and reduced stage 2 and slow-wave sleep (SWS) in both groups. However, caffeine reduced sleep efficiency more strongly in the DayRec group, and decreased sleep duration and REM sleep only in that group. The stronger effects of caffeine on daytime recovery sleep compared to nocturnal sleep are probably the consequence of the combined influence of increasing circadian wake propensity drive and the dissipation of homeostatic sleep pressure. We propose that the reduction of SWS by caffeine during daytime sleep increases the impact of the circadian wake signal on sleep. These results have implications for individuals using caffeine during night time. Neuropsychopharmacology (2007) 32, 964-972.

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“…1 Due to its behavioral and psychomotor stimulating properties, it is used to maintain vigilance, memory, and performance levels during limited sleep deprivation. [2][3][4][5][6][7][8] Some prolonged sleep deprivation and wake-sleep rhythm disruptions are common in everyday life, especially in emergency cases, during rescue operations, in the army, or during transmeridian flights. These situations lead to a certain number of vigilance and performance alterations, which in turn lead to a decrease in efficacy or to the onset of penalizing symptomatology.…”

mentioning

confidence: 99%

Slow-Release Caffeine: A New Response to the Effects of a Limited Sleep Deprivation

Lagarde

Batejat

Sicard³

et al. 2000

Sleep

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. It is found in coffee, of course, but also in tea, chocolate-flavored products and cola-based beverages, etc. 1 Due to its behavioral and psychomotor stimulating properties, it is used to maintain vigilance, memory, and performance levels during limited sleep deprivation. [2][3][4][5][6][7][8] Some prolonged sleep deprivation and wake-sleep rhythm disruptions are common in everyday life, especially in emergency cases, during rescue operations, in the army, or during transmeridian flights. These situations lead to a certain number of vigilance and performance alterations, which in turn lead to a decrease in efficacy or to the onset of penalizing symptomatology. [9][10][11][12] However, the results obtained with the use of caffeine to increase vigilance and performance level vary greatly. Sometimes, the results are very positive; an increase in performance mainly in visual vigilance tasks 13 can be observed as well as an increase in the level of awakeness-measured by electrophysiological techniques 2 -for unusual situations such as night work. Other studies reported an absence of effects or heterogeneous results 14 and sometimes negative effects such as the onset of tolerance during repeated intake of caffeine 15 or the onset of anxiety with still relatively low doses (325 mg). 16 In a general way, all the studies selected from a bibliographic research report an unquestionable stimulating and awaking effect of caffeine, but the effect has a limited power-especially compared with amphetamine-and duration. 17,18 Moreover, repeated caffeine intake can lead to the onset of deleterious cardiovascular or neurological side effects when the dose exceeds 600 mg. Therefore, it seemed interesting to assess the effects of a new galenic form of caffeine called " slowrelease " caffeine (SR caffeine) Stinergic. The release of Study Objectives: The aim of this study is to assess the interest of the intake of a new galenic form of caffeine called " slowrelease " caffeine (SR caffeine) during a decrease of vigilance due to a limited sleep deprivation. Design: The controlled method used compared three doses of SR caffeine (150, 300 and 600 mg) with a placebo. Tests were performed 2, 9 and 13 hours after each treatment. Wakefulness level was assessed subjectively through questionnaires and analog visual scales, and objectively with the Multiple Sleep Latency Test. Performance level was also assessed regularly with an attention test, a grammatical reasoning test, a spatial recognition test, a mathematical processing test, a visual tracking test, a memory search test, and a dual task. The motor activity was evaluated by wrist actimeter and safety of treatment was observed by regular clinical examination. Setting: NA Participants: Twenty-four young and healthy volunteers (12 men and 12 women) participated in a 32-hour sleep deprivation. Interventions: NA Results: The results show a significant effect of slow-release caffeine vs. placebo, and on vigilance and performance when subjects became tired. The effects of SR caffeine lasted 13...

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The Effects of Caffeine on Simulated Night-Shift Work and Subsequent Daytime Sleep

Cited by 98 publications

References 0 publications

Modafinil Attenuates Disruptions in Cognitive Performance During Simulated Night-Shift Work

Modafinil Attenuates Disruptions in Cognitive Performance During Simulated Night-Shift Work

Effects of Caffeine are more Marked on Daytime Recovery Sleep than on Nocturnal Sleep

Slow-Release Caffeine: A New Response to the Effects of a Limited Sleep Deprivation

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