The effects of caffeic acid phenethyl ester on streptozotocin-induced diabetic liver injury

Taşlıdere, Elif; Gül, Murat; Elbe, Hülya; Çetin, Aslı; Vardı, Nigar; Özyalın, Fatma; Türköz, Yusuf

doi:10.4149/bll_2016_054

Cited by 7 publications

(2 citation statements)

References 34 publications

(40 reference statements)

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“…Caffeic acid phenethyl ester (CAPE) is a major active phenolic compound of some types of propolis 14, 15 . It has been shown to be protective against oxidative stress-mediated tissue damage [16][17][18][19] . CAPE has been associated with a variety of in vitro and in vivo pharmacological effects 20-23 , and there have been reports of its gastroprotective activity in animal models.…”

Section: Introductionmentioning

confidence: 99%

CAPE Improves Vanin-1/AKT/miRNA-203 Signaling Pathways in DSS-induced Ulcerative Colitis

et al. 2022

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Introduction: Ulcerative colitis (UC) and other inflammatory bowel diseases (IBDs) are common chronic, inflammatory gastrointestinal diseases. Due to their antioxidant, anti-inflammatory, and antibacterial properties, polyphenols are beneficial in the treatment of IBD. Caffeine acid phenethyl ester (CAPE) has been shown to have cytotoxic, antibacterial, antioxidant, and anti-inflammatory effects. This study focuses on the biochemical and molecular levels of the mode of action of CAPE in DSS-induced UC in rats. Methods: Thirty male Wistar rats were distributed into five groups, with six rats in each group: group I was administered 3 mL of distilled water orally, group II was administered CAPE (10 mg/kg.b.w.) orally, group III was administered 5% DSS orally, group IV was administered 5% DSS and CAPE (10 mg/kg.b.w.) orally; and group V was administered 5% DSS and sulfasalazine (100 mg/kg b.w.) orally. Results: Individually, oral treatment with CAPE or sulfasalazine significantly ameliorated body weight, DAI score, and colon length in DSS-induced colitis and raised blood PLT count, NO, NF-kβ , and vitamin C levels. In addition, animals given CAPE had a considerable increase in colon GSH, GPx, CAT, and SOD levels compared with rats given DSS. Compared with the DSS control group, colon TBAR, IL-6, and INF-γ were lower in the CAPE-treated rats. Histopathological examination revealed that CAPE treatment caused tissue injury and improved vanin-1, AKT, and miRNA-203 genes in the distal colon and triggered apoptosis. Conclusions: The gastroprotective impact of CAPE was more noticeable than sulfasalazine. CAPE treatment caused biochemical and histopathological improvements, indicating that CAPE may have antioxidant and anti-inflammatory effects in colitis; therefore, CAPE may be a potential therapeutic agent for the amelioration of IBD. This finding is promising for future therapies and research goals.

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Section: Introductionmentioning

confidence: 99%

CAPE Improves Vanin-1/AKT/miRNA-203 Signaling Pathways in DSS-induced Ulcerative Colitis

et al. 2022

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“…Destes compostos, o fenetil éster do ácido cafeico (figura 10), é um composto polifenólico sintetizado pelas plantas (WANG et al, 2009), sendo o maior constituinte da própolis providas de regiões temperadas (HUANG et al, 2014) TASLIDERE et al, 2015).…”

Section: Fenetil éSter Do áCido Cafeico (Cape)unclassified

Ação do fenetil éster do ácido cafeico (CAPE) em >i<Leishmania (Leishmania) amazonensis>/i<

Mesquita¹

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Primeiramente gostaria de agradecer a Deus por me guiar nestes anos, me dando forças para seguir em cada noite virada, me dando inspiração e atendendo minhas preces nos momentos mais difíceis. Também não posso deixar de agradecer meus pais, Maria Marcia Scherma Mesquita e João Maria Mesquita pelo apoio e conforto emocional, além do incentivo de nunca deixar abater nas adversidades. Ao meu namorado, Danilo Aparecido Meler, agradeço todo o carinho, paciência e ajuda prestada nestes anos, por mais que houve tropeços nestes tempos difíceis, tudo teria sido mais difícil sem você. A Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) pelo financiamento da pesquisa através da bolsa nº 19/23769-4. Aos meus orientadores Dr. Edson Roberto da Silva e Dra. Claudia do Carmo Maquiaveli, pela grande oportunidade que me deram em ser orientado, no período que passei sob seus ensinamentos foram compartilhados muito além de saberes técnicos e científicos, mas valores humanos que vão além das páginas dos artigos e paredes do laboratório. A Andressa Parca e Thaís Ribeiro Fadel por tudo que vivemos nas aulas, trabalhos, viagens e momentos de mútuo apoio foi graças a vocês que cheguei ao final com uma bagagem cheia de vivências e amadurecimento. A Tamiris Maganha, Amanda Murarolli Marinho e Camila Silveira Stanquini vocês também foram grandes companheiras de caminhada. Aos alunos Gabriel Santos, Gabriel Andrade e Bárbara Hild, nós ficamos muito tempo juntos, rimos e sofremos não somente nos resultados não alcançados, mas no nosso campo pessoal e sempre tentamos nos ajudar mesmo que em simples conselhos.

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Antidiabetic and hepatoprotective activity of the roots of Calanthe fimbriata Franch

Peng

Gao

Zhang

et al. 2019

Biomedicine & Pharmacotherapy

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The effects of caffeic acid phenethyl ester on streptozotocin-induced diabetic liver injury

Cited by 7 publications

References 34 publications

CAPE Improves Vanin-1/AKT/miRNA-203 Signaling Pathways in DSS-induced Ulcerative Colitis

CAPE Improves Vanin-1/AKT/miRNA-203 Signaling Pathways in DSS-induced Ulcerative Colitis

Ação do fenetil éster do ácido cafeico (CAPE) em >i<Leishmania (Leishmania) amazonensis>/i<

Antidiabetic and hepatoprotective activity of the roots of Calanthe fimbriata Franch

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