The Effects of C-Reactive Protein, Interleukin-6, and Tumor Necrosis Factor-α in Rat Allograft Adventitial Inflammation and Allograft Arteriosclerosis

Sun, Honggang; Lu, Xuesong; Wu, Shanshan; Sun, Wenyu

doi:10.1016/j.transproceed.2009.06.190

Cited by 11 publications

(7 citation statements)

References 12 publications

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“…In this present study, hs-CRP 29) , which is known as a factor related to arteriosclerosis, showed a tendency to decrease (Table 6). Moreover, serum LPO decrease and antioxidant property (PAO and STATS) increase were recognized as other factors in arteriosclerosis ( Table 7).…”

Section: Discussionsupporting

confidence: 62%

Assessment of Anti-Aging Effects of Fish Products Peptide in Middle-Aged Subjects

et al. 2011

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Objective: In this study, the antioxidant properties of peptide from boiled fish paste (fish products peptide; FPP) supplement were investigated in middle-aged subjects. Methods:The subjects who participated in this study were men and premenopausal women, aged between 30 and 50 years (39.6 ± 5.5 years). The subjects consumed 10 tablets/day (containing 0.9 g of total fish peptide) for 60 days. Pre-and post-supplementation, subjects underwent analysis by physical measurement, completed the Anti-Aging QOL Common Questionnaire, and were examined in terms of vascular features, blood biochemical and uric characteristics, and hormone and oxidative stress markers. Results: After 60 days of supplementation with FPP, significant improvement was observed in serum lipid peroxide (LPO) (-16.2 %, p = 0.001). In terms of oxidative markers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) showed a tendency to decrease; in addition, potential antioxidant (PAO) and serum total antioxidant status (STAS), as antioxidant properties, showed slight increases. Furthermore, highsensitivity C-reactive protein (hs-CRP) also exhibited a tendency to decrease. Discussion: The results show that FPP might contribute to the prevention of lifestyle-related disease by regulating the balance of oxidative stress and improving arteriosclerosis with high oxidative stress.

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Section: Discussionsupporting

confidence: 62%

Assessment of Anti-Aging Effects of Fish Products Peptide in Middle-Aged Subjects

et al. 2011

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“…1,2 In accordance, we did not detect inflammatory cells in the explants after 4 and 12 weeks in vivo. 36 Furthermore, IL-6 is known to induce the development and destabilization of atherosclerotic plaques. IL-6 is FIGURE 6.…”

Section: Calcifying Graft Degenerationmentioning

confidence: 99%

Simvastatin Does Not Diminish the In Vivo Degeneration of Decellularized Aortic Conduits

Assmann

Horstkötter

Munakata

et al. 2014

Journal of Cardiovascular Pharmacology

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In a standardized small animal model of accelerated cardiovascular calcification, simvastatin failed to diminish the calcification of decellularized aortic conduit implants. This finding confirms the observations of recent clinical trials. However, further experiments are warranted to elucidate the value of partial benefits associated with lower circulating lipid and proinflammatory cytokine levels.

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“…Neurotransmitters secreted by the sympathetic and vagal fibers can decrease vascular tone and partially dilate the vessels when endothelial function is impaired [55]. C-reactive protein, IL-6 and TNF-α contribute to the development of allograft adventitial inflammation and arteriosclerosis [56]. As one of the major components of adventitia, the ECM consists of collagen and elastic fibers.…”

Section: Adventitial Fibrosis and Ecm Depositionmentioning

confidence: 99%

Mechanism of arterial remodeling in chronic allograft vasculopathy

2011

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Chronic allograft vasculopathy (CAV) remains a major obstacle for long-term survival of grafts even though therapeutic strategies have improved considerably in recent years. CAV is characterized by concentric and diffuse neointimal formation, medial apoptosis, infiltration of lymphocyte or inflammatory cells, and deposition of extracellular matrix both in arteries and veins. Recent studies have shown that stem cells derived from the recipient contribute to neointimal formation under the regulation of chemokines and cytokines. Arterial remodeling in allografts eventually causes ischemic graft failure. The pathogenesis is multi-factorial with both immunologic and non-immunological factors being involved. The immunological factors have been discussed extensively in other articles. This review focuses mainly on the arterial remodeling that occurs in 3 layers of vessel walls including intimal injury, accumulation of smooth muscle-like cells in the neointimal, medial smooth muscle cell apoptosis, adventitial fibrosis, and deposition of extracellular matrix.

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The Effects of C-Reactive Protein, Interleukin-6, and Tumor Necrosis Factor-α in Rat Allograft Adventitial Inflammation and Allograft Arteriosclerosis

Cited by 11 publications

References 12 publications

Assessment of Anti-Aging Effects of Fish Products Peptide in Middle-Aged Subjects

Assessment of Anti-Aging Effects of Fish Products Peptide in Middle-Aged Subjects

Simvastatin Does Not Diminish the In Vivo Degeneration of Decellularized Aortic Conduits

Mechanism of arterial remodeling in chronic allograft vasculopathy

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