The effects of bright light therapy on depression and sleep disturbances in patients with Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials

Lin, Fabin; Su, Yixiao; Weng, Youliang; Lin, Xiaofeng; Weng, Huidan; Cai, Guofa; Cai, Guolong

doi:10.1016/j.sleep.2021.03.035

Cited by 26 publications

(25 citation statements)

References 41 publications

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“…In PD, a meta‐analysis aimed to explore the role of light therapy in depression and sleep disturbances. From randomized controlled trials totaling 173 patients, researchers found that this therapy significantly improved depression and insomnia symptoms (Lin et al, 2021). Light therapy was also recognized as antidepressant nonpharmacological therapy in bipolar depression (Dallaspezia & Benedetti, 2020).…”

Section: Circadian Rhythm‐based Therapiesmentioning

confidence: 99%

Circadian rhythm and disease: Relationship, new insights, and future perspectives

Neves

Albuquerque

Quintela

et al. 2022

Journal Cellular Physiology

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The circadian system is responsible for internal functions and regulation of the organism according to environmental cues (zeitgebers). Circadian rhythm dysregulation or chronodisruption has been associated with several diseases, from mental to autoimmune diseases, and with life quality change. Following this, some therapies have been developed to correct circadian misalignments, such as light therapy and chronobiotics. In this manuscript, we describe the circadian‐related diseases so far investigated, and studies reporting relevant data on this topic, evidencing this relationship, are included. Despite the actual limitations in published work, there is clear evidence of the correlation between circadian rhythm dysregulation and disease origin/development, and, in this way, clock‐related therapies emerge as great progress in the clinical field. Future improvements in such interventions can lead to the development of successful chronotherapy strategies, deeply contributing to enhanced therapeutic outcomes.

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Section: Circadian Rhythm‐based Therapiesmentioning

confidence: 99%

Circadian rhythm and disease: Relationship, new insights, and future perspectives

Neves

Albuquerque

Quintela

et al. 2022

Journal Cellular Physiology

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“…Another avenue for a therapeutic approach is treating prodromal disorders and comorbidities of PD. For instance, bright light therapy has been used in RCT studies and has been found to significantly improve insomnia, sleep quality, iRBD and depression in PD patients [ 100 , 101 , 102 ]. This approach also has the potential to address the underlying pathology by improving glymphatic clearance.…”

Section: Potential Therapeutic Approachesmentioning

confidence: 99%

Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson’s Disease

Scott-Massey

Boag

Magnier

et al. 2022

IJMS

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Parkinson’s disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative disease and the most prevalent neurodegenerative disorder after Alzheimer’s disease with a high incidence rate in the elderly population. PD is highly multifactorial in etiology and has complex and wide-ranging pathogenic mechanisms. Environmental exposures and genetic predisposition are prominent risk factors. However, current evidence suggests that an intimate link may exist between the risk factor of sleep disturbance and PD pathogenesis. PD is characterized by the pathological hallmarks of alpha-synuclein aggregations and dopaminergic neuron degeneration in the substantia nigra. The loss of dopamine-producing neurons results in both motor and non-motor symptoms, most commonly, bradykinesia, tremor, rigidity, psychiatric disorders, sleep disorders and gastrointestinal problems. Factors that may exacerbate alpha-synuclein accumulation and dopamine neuron loss include neuroinflammation and glymphatic system impairment. Extracellular alpha-synuclein can induce an inflammatory response which can lead to neural cell death and inhibition of neurogenesis. The glymphatic system functions most optimally to remove extracellular brain solutes during sleep and therefore sleep disruption may be a crucial progression factor as well as a risk factor. This literature review interprets and analyses data from experimental and epidemiological studies to determine the recent advances in establishing a relationship between glymphatic system dysfunction, sleep disturbance, and PD pathogenesis and progression. This review addresses current limitations surrounding the ability to affirm a causal link between improved glymphatic clearance by increased sleep quality in PD prevention and management. Furthermore, this review proposes potential therapeutic approaches that could utilize the protective mechanism of sleep, to promote glymphatic clearance that therefore may reduce disease progression as well as symptom severity in PD patients.

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“…Evidence also suggests that bright light therapy is effective for treating depression and sleep disturbances in PD. 25 Anxiety Clinically significant symptoms of anxiety are present in 30% to 35% of patients with PD at any given time, with about one-third of those patients meeting criteria for more than one anxiety disorder. Anxiety most commonly presents as generalized anxiety disorder, but can also present as panic attacks, social phobia, and agoraphobia, and is frequently comorbid with depression, with 65% to 90% of patients with one type of affective disorder meeting criteria for the other.…”

Section: Depressionmentioning

confidence: 99%

“…For severe or refractory depression, it has been well established that electroconvulsive therapy is effective, safe, and well tolerated in PD, with the added benefit of temporary improvement in parkinsonism. Evidence also suggests that bright light therapy is effective for treating depression and sleep disturbances in PD 25 …”

Section: Parkinson Diseasementioning

confidence: 99%

Diagnosis and Treatment of Cognitive and Neuropsychiatric Symptoms in Parkinson Disease and Dementia With Lewy Bodies

Weintraub¹,

Irwin²

2022

CONTINUUM: Lifelong Learning in Neurology

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The effects of bright light therapy on depression and sleep disturbances in patients with Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials

Cited by 26 publications

References 41 publications

Circadian rhythm and disease: Relationship, new insights, and future perspectives

Circadian rhythm and disease: Relationship, new insights, and future perspectives

Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson’s Disease

Diagnosis and Treatment of Cognitive and Neuropsychiatric Symptoms in Parkinson Disease and Dementia With Lewy Bodies

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