The effects of bone marrow aspirate, bone graft, and collagen composites on fixation of titanium implants

Babiker, Hassan; Ding, Ming; Sandri, Monica; Tampieri, Anna; Overgaard, Søren

doi:10.1002/jbm.b.32509

Cited by 16 publications

(18 citation statements)

References 43 publications

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“…The size of implant was designed according to the anatomy at the implantation site of sheep distal femur trabecular bone. Four titanium implants with 2 mm concentric gaps were inserted extra‐articularly into the medial and lateral femoral condyles . The gaps were filled with one of the four materials: allograft as control, ABM/P‐15, HA/βTCP‐PDLLA, or ABM/P‐15+HA/βTCP‐PDLLA.…”

Section: Methodsmentioning

confidence: 99%

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Efficacy of a small cell-binding peptide coated hydroxyapatite substitute on bone formation and implant fixation in sheep

Ding

Andreasen

Dencker

et al. 2014

J. Biomed. Mater. Res.

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Cylindrical critical size defects were created at the distal femoral condyles bilaterally of eight female adult sheep. Titanium implants with 2-mm concentric gaps were inserted and the gaps were filled with one of the four materials: allograft; a synthetic 15-amino acid cell-binding peptide coated hydroxyapatite (ABM/P-15); hydroxyapatite + βtricalciumphosphate+ Poly-Lactic-Acid (HA/βTCP-PDLLA); or ABM/P-15+HA/βTCP-PDLLA. After nine weeks, bone-implant blocks were harvested and sectioned for micro-CT scanning, push-out test, and histomorphometry. Significant bone formation and implant fixation could be observed in all four groups. Interestingly, the microarchitecture of the ABM/P-15 group was significantly different from the control group. Tissue volume fraction and thickness were significantly greater in the ABM/P-15 group than in the allograft group. Bone formation and bone ingrowth to porous titanium implant were not significantly different among the four groups. The ABM/P-15 group had similar shear mechanical properties on implant fixation as the allograft group. Adding HA/βTCP-PDLLA to ABM/P-15 did not significantly change these parameters. This study revealed that ABM/P-15 had significantly bone formation in concentric gap, and its enhancements on bone formation and implant fixation were at least as good as allograft. It is suggested that ABM/P-15 might be a good alternative biomaterial for bone implant fixation in this well-validated critical-size defect gap model in sheep. Nevertheless, future clinical researches should focus on prospective, randomized, controlled trials in order to fully elucidate whether ABM/P-15 could be a feasible candidate for bone substitute material in orthopedic practices.

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Section: Methodsmentioning

confidence: 99%

“…The wounds were closed with sutures in three layers. Three times daily 2.0 mL buprenorphine (0.03 mg/mL, Temgesic, Schering‐Plough, Denmark ) and once daily 9.0 mL ampicillin (250 mg/mL, Ampivet Vet, Boehringer Ingelheim, Denmark ) were given postoperatively for one week …”

Section: Methodsmentioning

confidence: 99%

Efficacy of a small cell-binding peptide coated hydroxyapatite substitute on bone formation and implant fixation in sheep

Ding

Andreasen

Dencker

et al. 2014

J. Biomed. Mater. Res.

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“…The gap was filled with the hydroxyapatite/collagen composites with or without bone marrow aspirate, autograft or allograft (control group). After 5 weeks observation period, the authors reported similar effect on fixation of the implant by autograft and allograft while the hydroxyapatite/collagen composites, with or without bone marrow aspirate, did not have an effect on early fixation of the implants . In a later study by the same authors using the same animal model, the 2 mm gap was filled with demineralized bone matrix (DBM), DBM with cancellous bone at a ratio of 1:3, DME with allograft at a ratio of 1:3 or allograft (control group).…”

Section: Discussionmentioning

confidence: 91%

“…After 5 weeks observation period, the authors reported similar effect on fixation of the implant by autograft and allograft while the hydroxyapatite/collagen composites, with or without bone marrow aspirate, did not have an effect on early fixation of the implants. 39 In a later study by the same authors using the same animal model, 40 the 2 mm gap was filled with demineralized bone matrix (DBM), DBM with cancellous bone at a ratio of 1:3, DME with allograft at a ratio of 1:3 or allograft (control group). After 6 weeks observation period, results showed inferior early effects of DBM alone compared to the other groups on early fixation of the titanium implants.…”

Section: Clinical Relevancementioning

confidence: 99%

Osseointegration of acellular and cellularized osteoconductive scaffolds: Is tissue engineering using mesenchymal stem cells necessary for implant fixation?

García‐Gareta

Hua

Blunn

2014

J Biomedical Materials Res

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The main issue associated with revision total hip replacements (rTHRs) is how to generate new bone adjacent to implants and achieve fixation of the revision implant. In its simplest form, bone tissue engineering (BTE) combines cells and scaffolds in vitro to replace damaged or lost bone in vivo. Our aim was to develop BTE porous TiAl6V4 constructs with a calcium-phosphate coating without or with mesenchymal stem cells (MSCs) seeded throughout the entire porous structure to enhance new bone formation and which could be used for rTHRs. Porous titanium scaffolds made by selective laser sintering were seeded throughout with autologous bone marrow MSCs and cultured in a perfusion bioreactor. Constructs were implanted in the medial femoral condyle of 20 skeletally mature mule sheep with and without a gap of 2.5 mm between the construct and the host bone. After 6 weeks, the addition of MSCs to the scaffolds did not significantly increase osseointegration or implant-bone fixation strength. However, in the defects with a gap, the cellularized constructs showed higher implant-bone contact area and implant-bone fixation strength. BTE can be applied to develop acellular or cellularized constructs with clinical application in rTHRs where a lack of bone stock is problematic.

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“…There are few studies in the literature that used pushout tests to evaluate the strength of the bone-implant interface in the calvaria, although this method is widely employed in other experimental bone surgery models, such as those of long bones of the limbs 22,23 . In an evaluation of the influence of growth hormone supplementation on calvarial healing using an identical protein-2 (BMP-2) after 15 weeks 25 , and of 138N using calcium deficient hydroxyapatite (CDHA) implants coated with chitosan and treated with BMP-2 after eight weeks 26 .…”

Section: Discussionmentioning

confidence: 99%

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

et al. 2014

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PURPOSE:To investigate the osseointegration properties of prototyped implants with tridimensionally interconnected pores made of the Ti 6 Al 4 V alloy and the influence of a thin calcium phosphate coating. METHODS:Bilateral critical size calvarial defects were created in thirty Wistar rats and filled with coated and uncoated implants in a randomized fashion. The animals were kept for 15, 45 and 90 days. Implant mechanical integration was evaluated with a push-out test.Bone-implant interface was analyzed using scanning electron microscopy. RESULTS:The maximum force to produce initial displacement of the implants increased during the study period, reaching values around 100N for both types of implants. Intimate contact between bone and implant was present, with progressive bone growth into the pores. No significant differences were seen between coated and uncoated implants. CONCLUSION:Adequate osseointegration can be achieved in calvarial reconstructions using prototyped Ti 6 Al 4 V Implants with the described characteristics of surface and porosity.

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The effects of bone marrow aspirate, bone graft, and collagen composites on fixation of titanium implants

Abstract: Autograft and allograft have similar effect on fixation of bone implants. HA/Collagen composite with or without BMA has no effect on the early fixation of bone implants in this sheep model.

Cited by 16 publications

References 43 publications

Efficacy of a small cell-binding peptide coated hydroxyapatite substitute on bone formation and implant fixation in sheep

Efficacy of a small cell-binding peptide coated hydroxyapatite substitute on bone formation and implant fixation in sheep

Osseointegration of acellular and cellularized osteoconductive scaffolds: Is tissue engineering using mesenchymal stem cells necessary for implant fixation?

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

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