The effects of body core hypothermia on blood flow in tumors heated with microwave radiation

Sutton, Carl H.; Carroll, F.B.; Castiglione, G.A.

doi:10.1016/0011-2240(75)90072-3

Cited by 1 publication

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“…Though mechanisms of increased effectiveness of tumor chemotherapy combined with differential hypothermia are not yet fully understood, it appears that besides enhanced tumor metabolism, an increased circulation of blood through the selectively warmed tissues in a profoundly cooled organism (or profoundly cooled organ system) might cause this effect [Popovic and Popovic, 1969;Popovic et al, 1969a]. Recently this effect has been demonstrated for selectively warmed tissues in hypothermic dogs, as for instance, part of a lobe that was rewarmed to a temperature of 37 to 39 øC while the remainder of the lung was profoundly cooled [Popovic et al, 1971b], or for microwave-heated tumors in hypothermic mice [Sutton et al, 1975;Sutton and Carroll, 1979].…”

Section: Introductionmentioning

confidence: 99%

Localized embedding of labelled microspheres by microwave heating in tissues of hypothermie dogs

Popovic¹,

Popovic²

1979

Radio Science

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In this study a hind leg of dogs was profoundly cooled while the gracilis muscle of the same leg was kept normothermic or slightly hyperthermic (37 to 39 øC) by microwave heating (differential hypothermia). The circulation (measured by trapping of Technetium Tc 99 labelled carbonized microspheres in capillaries) through the warmed muscle tissues was five to 12 times greater than that through the cold muscles of the same leg. When differential hypothermia was used to induce selective embedding of (y9o) Yttrium-loaded microspheres in the warm gracilus muscle of the cooled leg, pronounced damage (or even complete destruction) of normothermic muscle tissue was observed while leaving undamaged all other muscle tissue that was protected by cooling. It is suggested that differential hypothermia might be a useful tool for preferential embedding of biologically important pharmaceuticals or for preferential embedding of medical radio-nuclides whenever a superselective catheterization of tumors or of other tissues is not possible.

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Section: Introductionmentioning

confidence: 99%