The effects of blood transfusion on kidney functions in orthopaedic surgery

Abstract

Objective:The effects of perioperative blood transfusion on renal functions have been studied in various studies. In this study, we investigated the effects of blood transfusion on postoperative kidney functions in patients who underwent orthopaedic surgeries.Method:Total 136 patients who were operated for several orthopedic pathologies between June 2013 and December 2014 were evaluated. The patients were divided into two groups according to the amounts of blood transfusion. Ninety five patients (69.8%) who were transfused less than 3 units were included in Group 1 and 41 patients (30.2%) who received 3 and more units of blood were included in Group 2.Results:There were no statistical difference between the two groups in terms of preoperative gender, hypertension, diabetes mellitus, chronical renal failure and smoking habbits (P > 0.05). No statistical differences between the groups were seen in terms of postoperative hospital stay, pulmonary and other complications as well as mortality (P > 0.05). When the two groups were compared for blood parameters showing postoperative renal and other system functions, no statistical differences were detected (P > 0.05).Conclusion:Blood transfusion does not have negative effects on postoperative BUN and creatinine levels in patients operated for orthopaedic pathologies.

The effect of perioperative blood transfusion on kidney functions in total knee Arthroplasty

“…In this study, we evaluated GFR for renal functions in addition to the other values. No statistically significant difference was found between the groups regarding kidney functions 1…”

“…Patients undergoing total knee arthroplasty frequently receive blood transfusions. Along with an escalation in the financial burden, many studies have reported blood transfusion-associated medical complications 1,9,10. Transfusion-associated postoperative complications such as hemolytic, allergic reactions, transfusion-associated acute lung injury, transfusion-associated circulatory overload, graft versus host disease and infection and death after blood transfusion have been noted in many orthopedic studies and postoperative studies in other fields 2,5,11…”

“…In USA 3.9% of all blood transfusions used during orthopedic surgery are during knee arthroplasty 1,2. This increase in perioperative blood transfusions has resulted in a rise in mortality and morbidity rates 1,3…”