The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women

Zhao, Hongyan; Bi, Yufang; Ma, Lin-ying; Zhao, Lin; Wang, Tiange; Zhang, Lianzhen; Tao, Bei; Sun, Lin; Zhao, Yongju; Wang, Weiqing; Li, Xiaoyin; Xu, Man-yin; Chen, Jialun; Ning, Guang; Liu, Jianmin

doi:10.1016/j.clinbiochem.2012.08.024

Cited by 58 publications

(60 citation statements)

References 35 publications

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“…Zhao et al (67) observed statistically significant positive correlations (adjusted for age) between urinary BPA levels and BMI, WC and hip circumference in premenopausal women. Wang et al found a small, but statistically significant, positive trend between spot urine BPA levels and both BMI (continuous) and WC (continuous) (64) .…”

Section: Resultsmentioning

confidence: 98%

“…Table 1 summarizes the studies and their findings. Thirteen studies were cross-sectional (62)(63)(64)67,68,(71)(72)(73)(75)(76)(77)(78) , two were case-control (65,70) and two were prospective cohort studies (66,74) , but all data analyses were crosssectional. One of the cohort studies did prospectively evaluate rate of weight change, but only evaluated the association between BMI and urinary BPA levels at baseline (74) .…”

Section: Resultsmentioning

confidence: 99%

“…For six of the articles, body composition (BMI, WC and/or weight) was the primary outcome of interest (62)(63)(64)67,71,74) . Seven studies included only women (65,67,69,73,74,77,78) , nine of the studies were in general adult populations (62)(63)(64)66,67,70,71,75,76) , one study included men and women ≥60 years (72) and another included only 70-year-old men and women (79) .…”

Section: Resultsmentioning

confidence: 99%

“…Six studies measured serum BPA levels; four using a competitive ELISA (65,68,73,78) , one using HPLC paired with an electrochemical detector (77) and one using LC and tandem MS (LC-MS/MS) (79) . Ten studies measured total BPA in spot urine samples (62)(63)(64)67,(70)(71)(72)(74)(75)(76) , one study used the geometric mean for two spot samples collected during the same in vitro fertilization cycle (69) and one study measured total BPA in a 24 h urine sample (66) . Urinary BPA levels were measured using GC-MS (63) and/or HPLC and tandem MS (HPLC-MS/MS) (62)(63)(64)66,67,71,72,74) .…”

Section: Resultsmentioning

confidence: 99%

“…Three of the studies reported a limit of detection (LOD) or limit of quantification (LOQ) (77)(78)(79) , but only Bloom et al reported the number of participants below the LOD/LOQ (13·6 %) (77) . Mean or median urinary BPA levels in spot urine samples were difficult to compare across studies given that some studies reported means (62,63,67,69,70,75,76) , some reported medians (64,74) and some reported levels unadjusted for concentration (63,67,69,70,76) , while others reported creatinineadjusted concentrations (62,64,75) . LOD/LOQ were relatively similar across studies and ranged from 0·063 to 0·50 ng/ml.…”

Section: Resultsmentioning

confidence: 99%

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Bisphenol A exposure and associations with obesity among adults: a critical review

Oppeneer

Robien

2014

Public Health Nutr.

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Objective: To review the literature on bisphenol A (BPA) exposure and obesity in human populations. Design: Systematic review of the literature via searches of PubMed, EMBASE, Web of Science and reference lists for articles published to 1 August 2014. Setting: China, Italy, Japan, Republic of Korea, Sweden, UK, USA. Subjects: Adults (≥18 years). Results: Eighteen articles were identified and included in the review. Twelve studies included secondary evaluations of BPA exposure and BMI, and six studies evaluated body composition as the primary outcome. All analyses were crosssectional and no study included in the review received a positive quality rating (twelve negative, six neutral). Eight studies observed a statistically significant positive association between urinary or serum BPA levels and BMI, and ten studies observed no association. Studies where BMI was a primary outcome and studies of neutral quality were more likely to observe an association. Conclusions: Study results are conflicting and significant methodological issues limit the ability to draw conclusions from these studies. Prospective studies that measure BPA exposure and changes in body weight and composition are needed to establish temporality, causality and the direction of any observed associations.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Bisphenol A exposure and associations with obesity among adults: a critical review

Oppeneer

Robien

2014

Public Health Nutr.

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Maternal organophosphate flame‐retardant exposure alters offspring energy and glucose homeostasis in a sexually dimorphic manner in mice

Walley

Krumm

Yasrebi

et al. 2020

J of Applied Toxicology

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Persistent organic pollutants such as organophosphate flame retardants (OPFRs) can accumulate in the body and interact with nuclear receptors that control energy homeostasis. One sensitive window of exposure is during development, either in utero or neonatal. Therefore, we investigated if maternal exposure to a mixture of OPFRs alters metabolism on a low-fat diet (LFD) or a high-fat diet (HFD) in both male and female offspring. Wild-type C57Bl/6J dams were orally dosed with vehicle (sesame oil) or an OPFR mixture (1 mg/kg each of tris(1,3-dichloro-2-propyl) phosphate, triphenyl phosphate, and tricresyl phosphate) from gestation day 7 to postnatal day 14. After weaning, pups were fed LFD or HFD. To assess metabolism, we measured body weight and food intake weekly and determined body composition, metabolism, activity, and glucose homeostasis at 6 months of age. Although maternal OPFR exposure did not alter body weight or adiposity, OPFR exposure altered substrate utilization and energy expenditure depending on diet in both sexes. Systolic and diastolic blood pressure was increased by OPFR in male offspring. OPFR exposure interacted with HFD to increase fasting glucose in females and alter glucose and insulin tolerance in male offspring. Plasma leptin was reduced in male and female offspring when fed HFD, whereas liver expression of Pepck was increased in females and Esr1 (estrogen receptor α) was increased in both sex. The physiological implications indicate maternal exposure to OPFRs programs peripheral organs including the liver and adipose tissue, in a sex-dependent manner, thus changing the response to an obesogenic diet and altering adult offspring energy homeostasis.

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Environmental Impact on Bone Health

2022

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The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women

Cited by 58 publications

References 35 publications

Bisphenol A exposure and associations with obesity among adults: a critical review

Bisphenol A exposure and associations with obesity among adults: a critical review

Maternal organophosphate flame‐retardant exposure alters offspring energy and glucose homeostasis in a sexually dimorphic manner in mice

Environmental Impact on Bone Health

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