The Effects of Bisphenol A on Oxidative Stress, Antioxidant Defence, Histopathological Alterations and Lysozyme Activity in Narrow-Clawed Crayfish (Pontastacus leptodactylus)

Diler, Öznur; Özil, Öznur; Nane, İkbal Demet; Nazıroğlu, Mevlüt; Minaz, Mert; Aslankoç, Rahime; Özmen, Özlem; Atsatan, Kamil

doi:10.4194/trjfas19877

Cited by 6 publications

(2 citation statements)

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“…Based on a previous study, the whole body histological view of a healthy A. gueldenstadii larvae was presented in the current study [24]. The gills are the primary organs in contact with water, so they are the most important markers for histological studies [25].…”

Section: Histopathological Findingsmentioning

confidence: 99%

Acute Toxicity and Histopathological Assessment of Bisphenol A in Danube Sturgeon (<i>Acipenser gueldenstaedtii</i>) Larvae

Minaz,

Er,

et al. 2024

Pol. J. Environ. Stud.

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Bisphenol A (BPA), an important component of the plastics industry, is characterized as an endocrine disrupting toxic substance for aquatic organisms. This study focused on the toxic effects of BPA on endangered Danube sturgeon larvae (Acipenser gueldenstaedtii). In the study, LC 50 values for five different BPA concentrations (100, 200, 400, 800, 1200 µg/L) were observed as 803.4 µg/L, 63.1 µg/L, and 39.6 µg/L at 24 th , 48 th and 72 nd hours, respectively. Especially, the lethal effect of BPA on the larvae was remarkable after the 24 th hour. On the other hand, histopathological changes were examined based on the LC 50 value at the 24 th hour. Vacuolization symptom was noted in the gills of the larvae. In addition, vacuolization and melanomacrophage centers caused a severe degradation in liver and kidney tissues of BPA group. In the intestine, the number of goblet cells per ville was lower in the BPA group. As a result, it has been proven by LC 50 and histopathological studies that BPA has high toxicity in A. gueldenstaedtii larvae.

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Section: Histopathological Findingsmentioning

confidence: 99%

Acute Toxicity and Histopathological Assessment of Bisphenol A in Danube Sturgeon (<i>Acipenser gueldenstaedtii</i>) Larvae

Minaz,

Er,

et al. 2024

Pol. J. Environ. Stud.

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“…In aquatic animals, there are different cellular strategies adapted by which they show defence against oxidative stress. Mainly it is with the scavenging effect of small antioxidants and antioxidant enzymes (Diler et al, 2022). But due to anthropogenic activities and increased environmental factors such as pH, temperature, and chemical pollutants, damage incurred to the cellular antioxidant system (Valavanidis et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Water physicochemical factors and oxidative stress physiology in fish, a review

Menon,

Kumar,

Middha

et al. 2023

Front. Environ. Sci.

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Fish are among the best-studied aquatic animals due to their economic and ecological values. Fish meat is the most affordable protein source for the economically weaker section of people. The environment of almost all aquatic ecosystems has a specific influential role on or by fishes. Therefore, studying their stress biology, especially oxidative stress, is vital because it can influence their growth, production, reproduction, etc. To review the above topic, peer-reviewed electronic databases, including Web of Science, science direct, PubMed, Google Scholar, Scopus, and AGRICOLA, were searched with specific keywords associated with fish, oxidative stress, diseases, etc. The influence of abiotic stress, such as the effects of water dissolved oxygen, temperature, salinity, water hardness, alkalinity, pH, pollutants, heavy metals, and anthropogenic activities, was reviewed in the current article to draw a conclusion on the updated relation that exists between fish physiology, disease, and abiotic stressors. Oxidative stress and redox regulatory levels under the above parameters were reviewed as the stress or anti-stress responses differ in various fish models. Undoubtedly, the reviewed abiotic factors modulate fish oxidative health status to a greater extent, and therefore, these factors must be considered on a priority basis to improve the general health and immunity status of fish. The statement above remains valid in both saline and freshwater habitats.

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Long-term exposure of endangered Danube sturgeon (Acipenser gueldenstaedtii) to bisphenol A (BPA): growth, behavioral, histological, genotoxic, and hematological evaluation

Minaz,

Kurtoğlu

2024

Environ Sci Pollut Res

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Danube sturgeon (Acipenser gueldenstaedtii) which is identified as endangered species can be exposed to pollutants such as bisphenol A (BPA) that have a disruptive effect on the endocrine system at any time. Starting from this motivation, the current study focused on BPA toxicity in A. gueldenstaedtii juvenile individuals and its adverse effects in sub-lethal concentration. The median lethal concentration (LC50) of BPA was 5.03 mg/L in 96th hour. In the chronic period, 0.625 mg/L and 1.25 mg/L BPA concentrations were evaluated based on the result of acute study. Accordingly, growth performance was significantly decreased in BPA groups (1.25 mg/L BPA group was significantly lowest) compared to control (p < 0.05). In the acute period, behavioral disorders were standing at the bottom/corner of tank, slowing and stopping of gill movement, decreased response to stimuli, and death, respectively. While vacuolization was severe in the liver tissue of the fish in the acute period, intense necrosis and melanomacrophage centers were observed in the chronic period. In terms of genotoxicity, longer DNA migration was observed in all groups exposed to BPA than in the control group. In addition, lower erythrocyte and hemoglobin were observed in the BPA groups compared to control. As a result, the current study revealed toxic effect of BPA on A. gueldenstaedtii juvenile individuals and its negative results on fish physiology.

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The Effects of Bisphenol A on Oxidative Stress, Antioxidant Defence, Histopathological Alterations and Lysozyme Activity in Narrow-Clawed Crayfish (Pontastacus leptodactylus)

Cited by 6 publications

References 0 publications

Acute Toxicity and Histopathological Assessment of Bisphenol A in Danube Sturgeon (<i>Acipenser gueldenstaedtii</i>) Larvae

Acute Toxicity and Histopathological Assessment of Bisphenol A in Danube Sturgeon (<i>Acipenser gueldenstaedtii</i>) Larvae

Water physicochemical factors and oxidative stress physiology in fish, a review

Long-term exposure of endangered Danube sturgeon (Acipenser gueldenstaedtii) to bisphenol A (BPA): growth, behavioral, histological, genotoxic, and hematological evaluation

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