2021
DOI: 10.1016/j.bios.2021.113113
|View full text |Cite
|
Sign up to set email alerts
|

The effects of biofilms on tumor progression in a 3D cancer-biofilm microfluidic model

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
11
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
7
1

Relationship

4
4

Authors

Journals

citations
Cited by 27 publications
(13 citation statements)
references
References 72 publications
(80 reference statements)
0
11
0
Order By: Relevance
“…Chronic inflammation has been linked to many carcinogenesis stages, 25,26 and biofilm formation has been attributed to a potential etiological role in the development of some cancers. [27][28][29] Recent clinical studies have linked fungi (e.g., C. albicans) and cancer, claiming the need for more in vitro and in vivo studies in this area. 30,31 In a tumor microenvironment, the resident microbiota and its metabolites trigger metabolic signaling pathways, which further promote or suppress the malignant behavior of host cells.…”
Section: Discussionmentioning
confidence: 99%
“…Chronic inflammation has been linked to many carcinogenesis stages, 25,26 and biofilm formation has been attributed to a potential etiological role in the development of some cancers. [27][28][29] Recent clinical studies have linked fungi (e.g., C. albicans) and cancer, claiming the need for more in vitro and in vivo studies in this area. 30,31 In a tumor microenvironment, the resident microbiota and its metabolites trigger metabolic signaling pathways, which further promote or suppress the malignant behavior of host cells.…”
Section: Discussionmentioning
confidence: 99%
“…Cells can form compact clusters in our tapered microwell assay (Supplementary Figure 3). Besides, the inside walls of our microwell could provide sufficient depth to avoid turbulence incurred from media change while concentrating the cells for cluster formation [16] , [18] , [19] , [20] , [66] .…”
Section: Methodsmentioning
confidence: 99%
“…As optimized in our previous study, the resulting cluster size range would be clinically comparable to large cancer microclusters in vivo (≈50 cells). [30,31] To mimic the different co-localization of infectious bacteria within the TME, we first established a coating (CT) model with extratumoral bacterial aggregates using human-derived uropathogenic Escherichia coli (UPEC) strain UTI89 and colonizing (CL) model with infiltrating bacteria, respectively. UTI89 infection in the form of EBs or intratumoral bacteria (IB) strains was performed at a multiplicity of infection (MOI) rate (human cells: bacteria) of 1:1 for clinical relevance.…”
Section: Development Of the Tam Pieb Microfluidic Tumor Bacterial Mod...mentioning
confidence: 99%
“…We previously reported that biofilms promote cancer progression through cancer stem cells (CSCs) and induce higher chemoresistance in bladder cancer. [30] Here, we developed a novel cancer inflammation model (TAM PIEB ) that revealed the unique interactions of TAMs with bladder cancer cells in the presence of human-derived uropathogenic Escherichia coli (UPEC) strain UTI89. The integrated microfluidic-based tumor inflammatory model enabled in situ analysis and drug screening of TAM-tumor-bacteria 3D models.…”
Section: Introductionmentioning
confidence: 99%