The effects of binge MDMA on acquisition and reversal learning in a radial-arm maze task

Kay, Christian; Harper, David N.; Hunt, Maree

doi:10.1016/j.nlm.2011.02.010

Cited by 23 publications

(23 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the present MDMA results are consistent with those reported by Kay, Harper, and Hunt (2011). In the Kay et al investigation, Sprague-Dawley rats were exposed to a single drug binge experience consisting of four injections of MDMA with an inter-injection interval of two hours.…”

Section: Discussionsupporting

confidence: 91%

Differentiation of MDMA or 5-MeO-DIPT induced cognitive deficits in rat following adolescent exposure.

Compton¹,

Selinger²,

Westman³

et al. 2011

Psychology & Neuroscience

View full text Add to dashboard Cite

The so-called "club drug" Foxy or Methoxy Foxy (5-Methoxy-N,N-di(iso)propyltryptamine hydrochloride; 5-MeO-DIPT) is a newer drug of abuse that has recently gained in popularity among recreational users as an alternative to MDMA (Ecstasy). While considerable research into the consequences of MDMA use is available, much remains unknown about the neurobiological consequences of 5-MeO-DIPT use. In the present study, beginning at 35 days of age adolescent rats were given repeated injections of 10 mg/kg of 5-MeO-DIPT, MDMA, or a corresponding volume of isotonic saline. Adult animals (135 days old) were trained and tested on a number of tasks designed to assess the impact, if any, and severity of 5-MeO-DIPT and MDMA, on a series of spatial and nonspatial memory tasks. Both the 5-MeO-DIPT-and the MDMA-treated rats were able to master the spatial navigation tests where the task included a single goal location and all groups performed comparably on these phases of training and testing. Conversely, the performance of both groups of the drug-treated rats was markedly inferior to that of the control animals on a task where the goal was moved to a new location and on a response learning task, suggesting a lack of flexibility in adapting their responses to changing task demands. In addition, in a response learning version of a learning set task, 5-MeO-DIPT rats made significantly more working memory errors than MDMA or control rats. Results are discussed in terms of observed alterations in serotonin activity in the forebrain and the consequences of compromised serotoninergic systems on cognitive processes.

show abstract

Section: Discussionsupporting

confidence: 91%

Differentiation of MDMA or 5-MeO-DIPT induced cognitive deficits in rat following adolescent exposure.

Compton¹,

Selinger²,

Westman³

et al. 2011

Psychology & Neuroscience

View full text Add to dashboard Cite

show abstract

“…Able Gudelsky, Vorhees & Williams, 2006), or both (Cunningham, Raudensky, Tonkiss & Yamamoto, 2009). Based on these and similar findings, some have questioned whether impaired performance on classic working memory tasks reflects specific working memory deficits or more general cognitive impairments (Kay, Harper & Hunt, 2011). Additionally, results have been mixed with several studies failing to observe any cognitive deficits following binge MDMA exposure (e.g., Byrne, Baker & Poling, 2000; Slikker et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

“…In Experiment 2, after the initial assessment, a contingency reversal of the simple discrimination was performed to test for effects of binge MDMA on behavioral flexibility. This was done in an attempt to replicate the findings of Kay, Harper and Hunt (2011) who found residual deficits in reversal learning in the radial arm maze following binge exposure to MDMA.…”

Section: Introductionmentioning

confidence: 99%

Effects of MDMA on olfactory memory and reversal learning in rats

Hawkey

April

Galizio

2014

Neurobiology of Learning and Memory

View full text Add to dashboard Cite

The effects of acute and sub-chronic MDMA were assessed using a procedure designed to test rodent working memory capacity: the odor span task (OST). Rats were trained to select an odor that they had not previously encountered within the current session, and the number of odors to remember was incremented up to 24 during the course of each session. In order to separate drug effects on the OST from more general performance impairment, a simple olfactory discrimination was also assessed in each session. In Experiment 1, acute doses of MDMA were administered prior to select sessions. MDMA impaired memory span in a dose-dependent fashion, but impairment was seen only at doses (1.8 and 3.0 mg/kg) that also increased response omissions on both the simple discrimination and the OST. In Experiment 2, a sub-chronic regimen of MDMA (10.0 mg/kg, twice daily over four days) was administered after OST training. There was no evidence of reduced memory span following sub-chronic MDMA, but a temporary increase in omission errors on the OST was observed. In addition, rats exposed to sub-chronic MDMA showed delayed learning when the simple discrimination was reversed. Overall, the disruptive effects of both acute and sub-chronic MDMA appeared to be due to non-mnemonic processes, rather than effects on specific memory functions.

show abstract

“…In rodents, exposure to MDMA repeatedly have been shown to produce deficits in the brain causing neuronal death or memory loss3132333435. Callahan and his colleagues found MDMA causes structural damage to axonal transport mechanisms in multiple brain regions36.…”

Section: Discussionmentioning

confidence: 99%

Effects of dextromethorphan on MDMA-induced serotonergic aberration in the brains of non-human primates using [123I]-ADAM/SPECT

Hsing

Liu

Weng

et al. 2016

Sci Rep

View full text Add to dashboard Cite

3,4-Methylenedioxymethamphetamine (MDMA), a common recreational drug, is known to cause serotonergic neurotoxicity in the brain. Dextromethorphan (DM) is a widely used antitussive reported to exert anti-inflammatory effect in vivo. In this study, we examined the long-term effect of MDMA on the primate serotonergic system and the protective property of DM against MDMA-induced serotonergic abnormality using single photon emission computed tomography (SPECT). Nine monkeys (Macaca cyclopis) were divided into three groups, namely control, MDMA and co-treatment (MDMA/DM). [123I]-ADAM was used as the radioligand for serotonin transporters (SERT) in SPECT scans. SERT levels of the brain were evaluated and presented as the uptake ratios (URs) of [123I]-ADAM in several regions of interest of the brain including midbrain, thalamus and striatum. We found that the URs of [123I]-ADAM were significantly lower in the brains of MDMA than control group, indicating lower brain SERT levels in the MDMA-treated monkeys. This MDMA-induced decrease in brain SERT levels could persist for over four years. However, the loss of brain SERT levels was not observed in co-treatment group. These results suggest that DM may exert a protective effect against MDMA-induced serotonergic toxicity in the brains of the non-human primate.

show abstract

The effects of binge MDMA on acquisition and reversal learning in a radial-arm maze task

Cited by 23 publications

References 54 publications

Differentiation of MDMA or 5-MeO-DIPT induced cognitive deficits in rat following adolescent exposure.

Differentiation of MDMA or 5-MeO-DIPT induced cognitive deficits in rat following adolescent exposure.

Effects of MDMA on olfactory memory and reversal learning in rats

Effects of dextromethorphan on MDMA-induced serotonergic aberration in the brains of non-human primates using [123I]-ADAM/SPECT

Contact Info

Product

Resources

About