The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

Liang, W.; Huang, Xiaobo; Chen, Wenqiang

doi:10.14336/ad.2017.0829

Cited by 179 publications

(108 citation statements)

References 106 publications

(126 reference statements)

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“…Baicalin has been extensively used in pharmaceutical and food industries due to its outstanding bioactivities. A number of in vitro and in vivo studies have demonstrated that baicalin possesses various pharmacological properties, including anti-inflammatory, anticancer, antidiabetic, antithrombotic, cardioprotective, hepatoprotective, and neuroprotective properties [ 8 , 9 ]. In particular, baicalin exhibits a variety of beneficial effects in the central nervous system (CNS) by promoting neural differentiation and inhibiting neuronal apoptosis [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review

et al. 2018

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Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the gradual loss of neurons. The development of effective neuroprotective agents to prevent and control neurodegenerative diseases is specifically important. Recently, there has been an increasing interest in selecting flavonoid compounds as potential neuroprotective agents, owing to their high effectiveness with low side effects. Baicalin is one of the important flavonoid compounds, which is mainly isolated from the root of Scutellaria baicalensis Georgi (an important Chinese medicinal herb). In recent years, a number of studies have shown that baicalin has a potent neuroprotective effect in various in vitro and in vivo models of neuronal injury. In particular, baicalin effectively prevents neurodegenerative diseases through various pharmacological mechanisms, including antioxidative stress, anti-excitotoxicity, anti-apoptotic, anti-inflammatory, stimulating neurogenesis, promoting the expression of neuronal protective factors, etc. This review mainly focuses on the neuroprotective and cognitive enhancement effects of baicalin. The aim of the present review is to compile all information in relation to the neuroprotective and cognitive enhancement effects of baicalin and its molecular mechanisms of action in various in vitro and in vivo experimental models.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review

et al. 2018

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“…Scutellaria baicalensis and its constituents have been shown to have neuroprotective, antioxidant, anti-apoptotic, antiinflammatory, and anti-excitotoxicity activity (93)(94)(95)(96). One of the active constituents found in Scutellaria baicalensis, baicalein, was found to exhibit in vitro activity against various morphologic forms of B. burgdorferi and B. garinii, including log phase spirochetes, latent round bodies, and biofilm formations (97).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi

Feng

Leone

Schweig³

et al. 2020

Front. Med.

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Lyme disease is the most common vector-borne disease in the US and Europe. Although the current recommended Lyme antibiotic treatment is effective for the majority of Lyme disease patients, about 10-20% of patients continue to suffer from persisting symptoms. There have been various anecdotal reports on the use of herbal extracts for treating patients with persisting symptoms with varying degree of improvements. However, it is unclear whether the effect of the herb products is due to their direct antimicrobial activity or their effect on host immune system. In the present study, we investigated the antimicrobial effects of 12 commonly used botanical medicines and three other natural antimicrobial agents for potential anti-Borrelia burgdorferi activity in vitro. Among them, 7 natural product extracts at 1% were found to have good activity against the stationary phase B. burgdorferi culture compared to the control antibiotics doxycycline and cefuroxime. These active botanicals include Cryptolepis sanguinolenta, Juglans nigra (Black walnut), Polygonum cuspidatum (Japanese knotweed), Artemisia annua (Sweet wormwood), Uncaria tomentosa (Cat's claw), Cistus incanus, and Scutellaria baicalensis (Chinese skullcap). In contrast, Stevia rebaudiana, Andrographis paniculata, Grapefruit seed extract, colloidal silver, monolaurin, and antimicrobial peptide LL37 had little or no activity against stationary phase B. burgdorferi. The minimum inhibitory concentration (MIC) values of Artemisia annua, Juglans nigra, and Uncaria tomentosa were quite high for growing B. burgdorferi, despite their strong activity against the non-growing stationary phase B. burgdorferi. On the other hand, the top two active herbs, Cryptolepis sanguinolenta and Polygonum cuspidatum, showed strong activity against both growing B. burgdorferi (MIC = 0.03-0.06% and 0.25-0.5%, respectively) and non-growing stationary phase B. burgdorferi. In subculture studies, only 1% Cryptolepis sanguinolenta extract caused complete eradication, while doxycycline and cefuroxime and other active herbs could not eradicate B. burgdorferi stationary phase cells as many spirochetes were visible after 21-day subculture. Further studies are needed to identify the active constituents of the effective botanicals and evaluate their combinations for more effective eradication of B. burgdorferi in vitro and in vivo. The implications of these findings for improving treatment of persistent Lyme disease are discussed.

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“…Baicalein is a common component of Carthami Flos and Radix paeoniae Rubra. As an important avonoids, it has many pharmacological activities, such as antioxidant stress, anti-in ammatory, anti-excitatory toxicity, anti-apoptosis, stimulating neurogenesis and promoting the expression of neuroprotective factors [50][51][52]. Liu et al found that baicalein had protective effect on transient middle cerebral artery occlusion model rats, and could signi cantly reduce the apoptosis of ischemic penumbra cells around the ischemic infarct of middle cerebral artery occlusion (MCAO) model rats [53].…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Buyang Huanwu Decoction in the treatment of Ischemic Stroke

Gao

Tian

Han

et al. 2020

Preprint

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Background and objective: With the exact clinical efficacy, Buyang Huanwu decoction (BHD) is a classical prescription for the treatment of ischemic stroke (IS). Here, we aimed to investigate the pharmacological mechanisms of BHD in treating IS using systems biology approaches.Methods: The bioactive components and potential targets of BHD were screened by TCMSP, BATMAN-TCM, ETCM, and SymMap databases. Besides, compounds that failed to find the targets from the above databases were predicted through STITCH, SWISS, and SEA. Moreover, six databases were searched to mine targets of IS. The intersection targets were obtained, and analyzed by GO and KEGG enrichment. Furthermore, BHD-IS PPI network, compound-compound target-IS network and pathway of drug-compound target-IS network were constructed by Cytoscape 3.6.0. Finally, AutoDock was used for molecular docking verification.Results：A total of 253 putative targets were obtained from 60 active compounds in BHD. Among them, 62 targets were related to IS. PPI network showed that the top ten key targets were IL6, TNF, VEGFA, and AKT1, etc. The enrichment analysis demonstrated candidate BHD targets were more frequently involved TNF, PI3K-Akt, and NF-kappa B signaling pathway. Network topology analysis showed that Radix Astragali was the main herb in BHD, and the key components were quercetin, beta-Sitosterol, kaempferol, and stigmasterol, etc. The results of molecular docking showed the active components in BHD had a good binding ability with the key targets.Conclusions: This study firstly adopted the methods of network pharmacology and molecular docking to reveal the relationships among herbs in BHD, the putative targets and IS-related pathways.

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The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

Cited by 179 publications

References 106 publications

Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review

Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review

Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi

Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Buyang Huanwu Decoction in the treatment of Ischemic Stroke

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