The effects of baicalein on gastric mucosal ulcerations in mice: Protective pathways and anti-secretory mechanisms

Ribeiro, Ana Roseli S.; Valença, José Diego do Nascimento; Santos, Jeferson da Silva dos; Boeing, Thaise; Silva, Luísa Mota da; Andrade, Sérgio Faloni de; Albuquerque‐Júnior, Ricardo Luiz Cavalcanti de; Thomazzi, Sara Maria

doi:10.1016/j.cbi.2016.10.016

Cited by 38 publications

(27 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NO has been confirmed to have an essential role in protection of the gastric mucosa via reduction of the secretion of gastric acid with increase of the mucus secretion . In consistent with previous studies, our findings revealed that IND significantly decreased the gastric eNOS and NO.…”

Section: Discussionsupporting

confidence: 92%

The prospective curative role of lipoxin A₄ in induced gastric ulcer in rats: Possible involvement of mitochondrial dynamics signaling pathway

et al. 2020

View full text Add to dashboard Cite

This study purposed to examine the prospective curative role of lipoxin A4 (LXA4) in induced gastric ulcer in rats and explore the possible involvement of mitochondrial dynamics signaling pathway. Forty‐eight male Wistar rats were divided into four groups: control, indomethacin (IND), IND + omeprazole (IND + Omez), and IND+ LXA4 groups. At the end of the experiment, the gastric pH, gastric fluid volume, total gastric acidity, ulcer index, and curative index were estimated. The gene expression of mitochondrial related protein 1 and mitofusin 2 were determined. In addition, some mitochondrial parameters include mitochondrial transmembrane potential, complex‐I activity and reactive oxygen species were measured. Also, some gastric biochemical parameters, histopathological, and immunohistochemical analyses of the gastric mucosa were determined. We found that IND induced gastric ulcer, as manifested by the biochemical, histopathological, and immunohistochemical analyses. Both Omez and LXA4 treatment for 15 days alleviated the IND‐induced gastric ulcer as explored by ameliorating the biochemical, histopathological, and immunohistochemical findings. We concluded that LXA4 mitigated the IND‐induced gastric ulcer via improving the mitochondrial dynamic imbalance and mitochondrial dysfunction, in addition to its anti‐apoptotic, anti‐inflammatory, and antioxidant properties.

show abstract

Section: Discussionsupporting

confidence: 92%

The prospective curative role of lipoxin A₄ in induced gastric ulcer in rats: Possible involvement of mitochondrial dynamics signaling pathway

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Peptic ulcers are lesions of the gastrointestinal tract, usually present in the stomach and duodenum (Chen et al, ) that affect about 10% of the population at some time in their life (García‐Martínez et al, ). Gastric ulceration is the result of an imbalance between gastroprotective factors and local irritation in the stomach (Ribeiro et al, ). Treatment of peptic ulcers focuses on eliminating pain, healing ulceration and preventing recurrence.…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls

Sánchez-Mendoza

López-Lorenzo

Matus-Meza

et al. 2017

Drug Development Research

View full text Add to dashboard Cite

Hit, Lead & Candidate Discovery The gastroprotective effect of calealactone B, isolated from Calea urticifolia was assessed in an ethanol-induced model of gastric lesioning. The possible involvement of prostaglandins, nitric oxide (NO) and sulfhydryl groups in the mechanism of action of calealactone B was also assessed. Calealactone B inhibited ethanol-induced gastric injuries with a maximal effect (95.3 ± 2.6%) at 30 mg kg . A similar value was obtained at 10 mg kg (83.5 ± 7.7%). Meanwhile, the reference anti-ulcer drug, carbenoxolone, an 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitor administered at 30 mg kg showed 63.5 ± 9.4% gastroprotection. Hence, calealactone B was more potent than carbenoxolone. Pretreatment with indomethacin, L-NAME or NEM did not reverse the effects of calealactone B, indicating that prostaglandins, NO and sulfhydryl compounds do not participate in its mechanism of action.

show abstract

“…H. pylori can be inhibited by baicalin and baicalein, demonstrating different degrees of antibacterial effects against Staphylococcus aureus , Streptococcus , Neisseria meningitidis , and diphtheria [8, 9]. Studies have found that baicalein antihistaminic effects are exerted to protect the gastric mucosa and prevent ulceration [10]. Angiogenesis can be inhibited by baicalein through inhibiting the expression of AP-1 in the inflammatory microenvironment, so as to exert its anti-inflammatory and antitumor effects [7].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Pudilan Anti-Inflammatory Oral Liquid on the Treatment of Mild Recurrent Aphthous Ulcers

Jin

Lin

Song

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Recurrent aphthous ulcers are the most common recurrent oral mucosal lesions characterized by recurrence and pain. The aim of this research is to evaluate the short-term curative effect of the traditional Chinese medicine “Pudilan anti-inflammatory oral liquid” on mild recurrent aphthous ulcers. A total of 234 patients were divided into a treatment group and a control group. Both groups used vitamin B2 as the basis of treatment. The treatment group took a Pudilan anti-inflammatory oral solution for 8 days while the control group was given a liquid placebo. The ulcer size, pseudomembrane, peripheral congestion, and pain scores of the treatment group were lower than before treatment. The curative effect on the Pudilan group was statistically significant compared with the control group. The final therapeutic effect on the treatment group was better than that on the control group. The healing time of mild recurrent aphthous ulcers can be shortened by Pudilan anti-inflammatory oral liquid, and pain is relieved without adverse reactions. Pudilan provides a new reference drug for the treatment of mild recurrent oral ulcers.

show abstract

The effects of baicalein on gastric mucosal ulcerations in mice: Protective pathways and anti-secretory mechanisms

Cited by 38 publications

References 77 publications

The prospective curative role of lipoxin A₄ in induced gastric ulcer in rats: Possible involvement of mitochondrial dynamics signaling pathway

The prospective curative role of lipoxin A₄ in induced gastric ulcer in rats: Possible involvement of mitochondrial dynamics signaling pathway

Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls

The Effect of Pudilan Anti-Inflammatory Oral Liquid on the Treatment of Mild Recurrent Aphthous Ulcers

Contact Info

Product

Resources

About

The effects of baicalein on gastric mucosal ulcerations in mice: Protective pathways and anti-secretory mechanisms

Cited by 38 publications

References 77 publications

The prospective curative role of lipoxin A4 in induced gastric ulcer in rats: Possible involvement of mitochondrial dynamics signaling pathway

The prospective curative role of lipoxin A4 in induced gastric ulcer in rats: Possible involvement of mitochondrial dynamics signaling pathway

Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls

The Effect of Pudilan Anti-Inflammatory Oral Liquid on the Treatment of Mild Recurrent Aphthous Ulcers

Contact Info

Product

Resources

About

The prospective curative role of lipoxin A₄ in induced gastric ulcer in rats: Possible involvement of mitochondrial dynamics signaling pathway

The prospective curative role of lipoxin A₄ in induced gastric ulcer in rats: Possible involvement of mitochondrial dynamics signaling pathway