The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial

Nazari, Leila; Salehpour, Saghar; Hosseini, Maryam Sadat; Moghanjoughi, Parisa Hashemi

doi:10.1080/14647273.2019.1569268

Cited by 58 publications

(56 citation statements)

References 27 publications

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“…It has been recently demonstrated that use of intrauterine platelet‐rich plasma (PRP) improves the outcomes of embryo transfer (ET) in patients suffering from repeated implantation failure (RIF) 1–3 . It has been proposed that intrauterine PRP infusion may assist the endometrium to accept the embryo, thereby eliminating one of the major pathologies associated with RIF.…”

Section: Introductionmentioning

confidence: 99%

Autologous platelet‐rich plasma infusion does not improve pregnancy outcomes in frozen embryo transfer cycles in women with history of repeated implantation failure without thin endometrium

Tehraninejad

Kashani

Hosseini

et al. 2020

J of Obstet and Gynaecol

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AimThe effect of intrauterine infusion of platelet‐rich plasma (PRP) which has been shown to improve the pregnancy outcomes in patients suffering from repeated implantation failure (RIF), is intended to be studied in patients with normal endometrial thickness.MethodsWe recruited 85 patients with RIF and normal endometrial thickness (≥7 mm). After obtaining their consent, they were stratified into the intervention (PRP) and control groups, according to the patient's decision. Out of 85 participants, 42 received PRP, while 43 were included in the control group. In the PRP group, 1 mL of PRP was extracted from 10 cc of whole blood via two rounds of centrifugation and infused 2 days before the embryo transfer (ET).ResultsThe pregnancy outcomes, including biochemical, clinical and ongoing pregnancy (≥20 weeks of gestation) rates were similar between the PRP (35.7, 31.0 and 26.8%, respectively) and control (37.2, 37.2 and 25.6%, respectively) groups.ConclusionWe concluded that PRP is not an effective adjuvant treatment for in vitro fertilization of patients with RIF and normal endometrial thickness undergoing ET.

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Section: Introductionmentioning

confidence: 99%

Autologous platelet‐rich plasma infusion does not improve pregnancy outcomes in frozen embryo transfer cycles in women with history of repeated implantation failure without thin endometrium

Tehraninejad

Kashani

Hosseini

et al. 2020

J of Obstet and Gynaecol

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“…Moreover, PRP therapy has attracted attention as an effective therapy for RIF. 14,20,21 Future research issues include investigation of the therapeutic effects of PRP on factors not limited to endometrial thickness, and the precise molecular mechanism of the effect of PRP must be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Intrauterine administration of platelet‐rich plasma improves embryo implantation by increasing the endometrial thickness in women with repeated implantation failure: A single‐arm self‐controlled trial

Kusumi

Ihana

Kurosawa

et al. 2020

Reprod Medicine & Biology

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“…A study group from Teheran [ 31 ] investigated 138 patients with repeated implantation failure in 2016 and 2017. The women failed to conceive after three or more embryo transfers with high-quality embryos.…”

Section: Discussionmentioning

confidence: 99%

“…The biochemical pregnancy rate was higher in the PRP group than in controls (53.06% versus 27.08%, respectively; p = 0.009) and the clinical pregnancy rate was also higher in the PRP group than in controls (44.89% versus 16.66%, respectively; p = 0.003). The authors concluded that PRP infusions cause higher pregnancy rates in women with repeated implantation failure [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Management of a Thin Endometrium by Hysteroscopic Instillation of Platelet-Rich Plasma Into The Endomyometrial Junction: A Pilot Study

Agarwal

Mettler

Jain

et al. 2020

JCM

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In patients whose embryo transfer has been previously canceled due to a thin endometrium, the injection of platelet-rich plasma (PRP) guided by hysteroscopy into the endomyometrial junction improves endometrial thickness and vascularity. This may well serve as a novel approach for the management of these patients. In this study, 32 patients aged between 27 and 39 years, suffering from primary or secondary infertility, were selected for hysteroscopic instillation of PRP. This cross-sectional study included a retrospective assessment of the improvement of endometrial thickness (>7 mm) on the commencement of progesterone treatment in 24 of 32 patients (75%) after hysteroscopy-guided injections of PRP into the subendometrial zone. After PRP instillation, the endometrium was 7 mm or thicker in 24 of 32 patients, and all 24 patients underwent frozen embryo transfer. Moreover, 12 of 24 patients who underwent embryo transfer conceived, whereas 10 had a clinical pregnancy with visualization of cardiac activity at 6 weeks and two had a biochemical pregnancy. Our approach of PRP injection into the subendometrial region is consistent with the histologically proven regeneration of the endometrium from the endomyometrial junction. We observed an improvement of endometrial thickness and higher pregnancy rates in cases of previously canceled embryo transfer due to a thin endometrium.

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The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial

Cited by 58 publications

References 27 publications

Autologous platelet‐rich plasma infusion does not improve pregnancy outcomes in frozen embryo transfer cycles in women with history of repeated implantation failure without thin endometrium

Autologous platelet‐rich plasma infusion does not improve pregnancy outcomes in frozen embryo transfer cycles in women with history of repeated implantation failure without thin endometrium

Intrauterine administration of platelet‐rich plasma improves embryo implantation by increasing the endometrial thickness in women with repeated implantation failure: A single‐arm self‐controlled trial

Management of a Thin Endometrium by Hysteroscopic Instillation of Platelet-Rich Plasma Into The Endomyometrial Junction: A Pilot Study

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