The effects of Aspergillus fumigatus challenge on exhaled and nasal NO levels

Hj, Stark; Jt, Randell; Hirvonen, M.-R.; Mk, Purokivi; Roponen, Marjut; H, Tukiainen

doi:10.1183/09031936.05.00061405

Cited by 16 publications

(13 citation statements)

References 36 publications

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“…However, available data on expression dynamics of some biomarkers were limited or inconsistent. For example, an increase in FeNO has been observed right after swimming (Carbonnelle et al 2002) and also 6 hr after mold exposure (Stark et al 2005). Therefore, undetected changes in some biomarkers due to inappropriate sample timing cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

“…A change in the concentration of lung surfactant proteins in serum has been proposed as a marker to detect early permeability changes in the lung epithelium (Broeckaert et al 2000). Fractional concentrations of orally exhaled nitric oxide (FeNO) is a marker of eosinophilic airway inflammation (Choi et al 2006) and has been shown to increase after short-term exposure to mold (Stark et al 2005). Soluble molecules can be detected in EBC, including proinflammatory cytokines, growth factors, and oxidative stress biomarkers, and have been used to monitor different aspects of diseases such as asthma or chronic obstructive pulmonary disease, as well as the effects of environmental stressors or physical exercise (Bonsignore et al 2003; Carbonnelle et al 2002, 2008; Massin et al 1998; Nanson et al 2001).…”

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confidence: 99%

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Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool

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Kogevinas

Zock

et al. 2010

Environ Health Perspect

100

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BackgroundSwimming in chlorinated pools involves exposure to disinfection by-products (DBPs) and has been associated with impaired respiratory health.ObjectivesWe evaluated short-term changes in several respiratory biomarkers to explore mechanisms of potential lung damage related to swimming pool exposure.MethodsWe measured lung function and biomarkers of airway inflammation [fractional exhaled nitric oxide (FeNO), eight cytokines, and vascular endothelial growth factor (VEGF) in exhaled breath condensate], oxidative stress (8-isoprostane in exhaled breath condensate), and lung permeability [surfactant protein D (SP-D) and the Clara cell secretory protein (CC16) in serum] in 48 healthy nonsmoking adults before and after they swam for 40 min in a chlorinated indoor swimming pool. We measured trihalomethanes in exhaled breath as a marker of individual exposure to DBPs. Energy expenditure during swimming, atopy, and CC16 genotype (rs3741240) were also determined.ResultsMedian serum CC16 levels increased from 6.01 to 6.21 μg/L (average increase, 3.3%; paired Wilcoxon test p = 0.03), regardless of atopic status and CC16 genotype. This increase was explained both by energy expenditure and different markers of DBP exposure in multivariate models. FeNO was unchanged overall but tended to decrease among atopics. We found no significant changes in lung function, SP-D, 8-isoprostane, eight cytokines, or VEGF.ConclusionsWe detected a slight increase in serum CC16, a marker of lung epithelium permeability, in healthy adults after they swam in an indoor chlorinated pool. Exercise and DBP exposure explained this association, without involving inflammatory mechanisms. Further research is needed to confirm the results, establish the clinical relevance of short-term serum CC16 changes, and evaluate the long-term health impacts.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool

Font-Ribera

Kogevinas

Zock

et al. 2010

Environ Health Perspect

100

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“…So far, several studies have shown an elevation of FENO after bronchial allergen challenges (17–19). However, to our knowledge, only one study exists, which has shown a rise of FENO after nasal allergen challenge in children with allergic rhinitis to mites (20), while other authors could not provoke an elevation of FENO in patients with rhinitis (21, 22).…”

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confidence: 99%

Effect of natural seasonal pollen exposure and repeated nasal allergen provocations on elevation of exhaled nitric oxide

Bergmann-Hug

Wirth²,

Henseler³

et al. 2009

Allergy

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“…However, there are inconsistent findings among the few studies that have explored the association between eNO levels and indoor microbial contamination. Experimental studies with adults have demonstrated elevated eNO levels after respiratory challenge with endotoxin (Kitz et al, 2006) and Aspergillus fumigatus (Stark et al, 2005). In contrast, Purokivi et al (2002) measured eNO levels in employees working in moisture damaged buildings versus reference buildings and detected no association.…”

Section: Introductionmentioning

confidence: 99%

Microbial content of household dust associated with exhaled NO in asthmatic children

Johansson

Reponen

Vesper

et al. 2013

Environment International

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Exhaled nitric oxide (eNO) is increasingly used as a non-invasive measure of airway inflammation. Despite this, little information exists regarding the potential effects of indoor microbial components on eNO. We determined the influence of microbial contaminants in house dust and other indoor environmental characteristics on eNO levels in seven-year-olds with and without a physician- diagnosis of asthma. The study included 158 children recruited from a birth cohort study, and 32 were physician-diagnosed as asthmatic. The relationship between eNO levels and exposures to home dust streptomycetes, endotoxin, and molds was investigated. Streptomycetes and endotoxin were analyzed both as loads and concentrations in separate models. Dog, cat, and dust mite allergens also were evaluated. In the multivariate exposure models high streptomycetes loads and concentrations were significantly associated with a decrease in eNO levels in asthmatic (p <0.001) but not in healthy children. The presence of dog allergen, however, was associated with increased levels of eNO (p = 0.001). Dust endotoxin was not significant. The relationship between eNO and indoor exposure to common outdoor molds was u-shaped. In non-asthmatic children, none of the exposure variables were significantly associated with eNO levels. To our knowledge, this is the first study demonstrating a significant association between microbial components in the indoor environment and eNO levels in asthmatic children. This study demonstrates the importance of simultaneously assessing multiple home exposures of asthmatic children to better understand opposing effects. Common components of the indoor Streptomyces community may beneficially influence airway inflammation.

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The effects of Aspergillus fumigatus challenge on exhaled and nasal NO levels

Cited by 16 publications

References 36 publications

Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool

Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool

Effect of natural seasonal pollen exposure and repeated nasal allergen provocations on elevation of exhaled nitric oxide

Microbial content of household dust associated with exhaled NO in asthmatic children

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