The effects of articaine hydrochloride on wound healing: an experimental study

Doğan, Necdet; Üçok, Cahi̇t; Korkmaz, Cem; Üçok, Özlem; Karasu, Hakan Alpay

doi:10.1016/j.joms.2003.05.002

Cited by 27 publications

(16 citation statements)

References 7 publications

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“…Reduced wound breaking strength and impaired healing were reported in rat models of acute wound repair after exposure to local anesthetics. 52 A recent study using a mouse model of cutaneous wound healing was unable to demonstrate adverse effects of lidocaine and bupivacaine, but the local anesthetics were applied only once over 3 days as bolus and not as continuous infusion.…”

Section: What Do Our Results Suggest With Respect To the Direct Applimentioning

confidence: 99%

Antiproliferative Effects of Local Anesthetics on Mesenchymal Stem Cells

Lucchinetti

Awad²,

Rahman³

et al. 2012

Anesthesiology

132

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Background: Mesenchymal stem cells (MSC) are self-renewing clonal progenitor cells of nonhematopoietic tissues that exhibit a marked tropism to wounds and tumors. The authors' studies aimed at exploring how local anesthetics would affect MSC biology. Methods: Proliferation, colony formation, in vitro wound healing, and bone differentiation assays of culture-expanded bone-marrow-derived murine MSC were performed in the presence of increasing concentrations of lidocaine, ropivacaine, and bupivacaine. Cytotoxicity was monitored by measuring lactate dehydrogenase activity and phosphatidylserine exposure/ propidium iodide staining (early apoptotic cells/necrotic cells). Measurements of mitochondrial function in intact and permeabilized cells, transcriptional changes, and changes in nuclear factor -light-chain-enhancer of activated B cells signaling in

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Section: What Do Our Results Suggest With Respect To the Direct Applimentioning

confidence: 99%

Antiproliferative Effects of Local Anesthetics on Mesenchymal Stem Cells

Lucchinetti

Awad²,

Rahman³

et al. 2012

Anesthesiology

132

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“…Today it is considered as a reference standard against which other local anesthetic agents are compared. Various studies have been done in dentistry evaluating the safety and efficacy of Articaine [10,11,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. Since its introduction in 1969, Articaine has gradually become implanted in Europe.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of 4 % Articaine and 2 % Lidocaine: A clinical study

Kambalimath¹,

Dolas

Kambalimath

et al. 2012

J. Maxillofac. Oral Surg.

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Objectives This study was undertaken to compare the anesthetic properties of 4 % Articaine hydrochloride and 2 % Lidocaine both with 1:100,000 epinephrine for mandibular inferior alveolar nerve anesthesia. Materials and Methods Thirty healthy patients were included in this randomized double-blind clinical cross over study. Each subject received each test solution at different times. Inferior alveolar nerve block anesthesia was used for extraction of bilateral impacted mandibular third molar on different occassions. The time of onset of action, duration of anesthesia, efficacy of anesthesia, hemodynamic parameters and oxygen saturation were monitored during the procedure. A visual analog scale was used to assess pain during surgery, and thus subjectively evaluate the anesthetic efficacy of the two solutions. Results No statistically significant differences were seen in the onset and duration of anesthesia between the Articaine and Lidocaine solutions. Conclusions 4 % Articaine offers better clinical performance than 2 % Lidocaine, particularly in terms of latency and duration of the anesthetic effect. However, no statistically significant differences in anesthetic efficacy were recorded between the two solutions.

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“…Then paraffin blocks were stained by hematoxylineosin and scored. For each sample, 10 different fields at a magnification of ×20 were examined and histopathological findings were categorized for the presence of epidermal regeneration, collagen bundles, fibroblastic proliferation and vascularity 8,9 ( Table 1). While the samples exactly show the features of the phase that they are in were scored as 1, samples that are between two phases was scored as 0.25 point.…”

Section: Histological Analysismentioning

confidence: 99%

Comparison of effects of unfractionated heparin and low molecular weight heparin on skin wound healing of rats

et al. 2012

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PURPOSE:To compare the effects of unfractionated heparin (UH) and a low molecular weight heparin (LMWH) on skin wound healing of rats. METHODS: Forty eight male Sprague-Dawley rats underwent 8mm full thickness dorsal skin wounds and were randomly assigned to three equal groups. In experimental group A, heparin sodium was injected at a concentration of 1000U/kg. In experimental group B, enoxaparin was injected at a concentration of 1mg/kg. Physiologic saline (0.5ml) was administered to the control group. Injections were made subcutaneously, once daily, for seven days. At 7 th and 10 th days tissue samples were taken from all rats. Histologic examination of these tissues was made under light microscope and scored. RESULTS: Histological examination showed a significant difference between the 7 th and 10 th day groups in wound healing. It was observed that wound healing of LMWH injected group is better. This difference is statistically significant at 10 th day. CONCLUSIONS: Daily administration of single doses of unfractionated heparin and a low molecular weight heparin improves wound healing positively. Low molecular weight heparin induces wound healing more than unfractionated heparin.

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The effects of articaine hydrochloride on wound healing: an experimental study

Cited by 27 publications

References 7 publications

Antiproliferative Effects of Local Anesthetics on Mesenchymal Stem Cells

Antiproliferative Effects of Local Anesthetics on Mesenchymal Stem Cells

Efficacy of 4 % Articaine and 2 % Lidocaine: A clinical study

Comparison of effects of unfractionated heparin and low molecular weight heparin on skin wound healing of rats

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