The Effects of Arterial Hypertension and Age on the Sublingual Microcirculation of Healthy Volunteers and Outpatients with Cardiovascular Risk Factors

Edul, Vanina Siham Kanoore; İnce, Can; Bakker, Jan; Ferrara, Gonzalo; Arzani, Yanina; Salvatori, Carolina; Dubin, Arnaldo

doi:10.1111/micc.12219

Cited by 28 publications

(24 citation statements)

References 47 publications

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“…measured the pulsatile ocular blood flow of diabetic patients, and the results suggested that subjects with systemic hypertension had an increased blood flow rate compared to controls without hypertension. In contrast, Kanoore Edul et al . said that there was no correlation between BP and blood flow in the sublingual microcirculation.…”

Section: Discussionmentioning

confidence: 94%

Effects of age, sex, and blood pressure on the blood flow velocity in dental pulp measured by Doppler ultrasound technique

Kim

Park

2016

Microcirculation

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Section: Discussionmentioning

confidence: 94%

Effects of age, sex, and blood pressure on the blood flow velocity in dental pulp measured by Doppler ultrasound technique

Kim

Park

2016

Microcirculation

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“…In a parallel observation, hypertensive patients had a lower sublingual capillary TVD than healthy controls unless they were exercising for at least 150 min week –1 , in which case they reached levels of TVD similar to those of healthy controls (Kanoore Edul et al . ). Also in patients with chronic mesenterial ischaemia, a lower TVD was found than in healthy controls, which increased in value upon caloric challenge, whereas healthy controls presented the same higher level of TVD at baseline, remaining unchanged after caloric challenge (Harki et al .…”

Section: Discussionmentioning

confidence: 97%

Recruitment of non‐perfused sublingual capillaries increases microcirculatory oxygen extraction capacity throughout ascent to 7126 m

Hilty

Merz

Hefti

et al. 2019

The Journal of Physiology

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Key pointsr A physiological response to increase microcirculatory oxygen extraction capacity at high altitude is to recruit capillaries. r In the present study, we report that high altitude-induced sublingual capillary recruitment is an intrinsic mechanism of the sublingual microcirculation that is independent of changes in cardiac output, arterial blood pressure or systemic vascular hindrance.r Using a topical nitroglycerin challenge to the sublingual microcirculation, we show that high altitude-related capillary recruitment is a functional response of the sublingual microcirculation as opposed to an anatomical response associated with angiogenesis.r The concurrent presence of a low capillary density and high microvascular reactivity to topical nitroglycerin at sea level was found to be associated with a failure to reach the summit, whereas the presence of a high baseline capillary density with the ability to further increase maximum recruitable capillary density upon ascent to an extreme altitude was associated with summit success.Abstract A high altitude (HA) stay is associated with an increase in sublingual capillary total vessel density (TVD), suggesting microvascular recruitment. We hypothesized that microvascular recruitment occurs independent of cardiac output changes, that it relies on haemodynamic changes within the microcirculation as opposed to structural changes and that microcirculatory function is related to individual performance at HA. In 41 healthy subjects, sublingual handheld vital microscopy and echocardiography were performed at sea level (SL), as well as at 6022 m Matthias Peter Hilty has found that, during his education and throughout his board certification in General Internal Medicine and Intensive Care Medicine, his main interests lie in the foundations of human physiology, in addition to their application in clinical practice. Studies of the response of the macro-and microcirculation to critical illness and high altitude environments have lead to his high appreciation of the contrast between witnessing cardiovascular pathophysiology during field studies, in laboratory settings and at the bedside. Hoping to support the upcoming challenge to translate these findings to clinical use, Dr Hilty is applying advanced computational techniques for the objective assessment of a patient's microcirculation. M. P. Hilty and othersJ Physiol 597.10 (C2) and 7042 m (C3), during ascent to 7126 m within 21 days. Sublingual topical nitroglycerin was applied to measure microvascular reactivity and maximum recruitable TVD (TVD NG ). HA exposure decreased resting cardiac output, whereas TVD (mean ± SD) increased from 18.81 ± 3.92 to 20.92 ± 3.66 and 21.25 ± 2.27 mm mm −2 (P < 0.01). The difference between TVD and TVD NG was 2.28 ± 4.59 mm mm −2 at SL (P < 0.01) but remained undetectable at HA. Maximal TVD NG was observed at C3. Those who reached the summit (n = 15) demonstrated higher TVD at SL (P < 0.01), comparable to TVD NG in non-summiters (n = 21) at SL and in both groups at C2. Recruitment of sublingu...

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“…Patients with active infections and bleeding were excluded. Cirrhotic patients were compared to the same number of noncirrhotic volunteers individually matched for age, sex, and cardiovascular risk factors . One‐year mortality was registered.…”

Section: Methodsmentioning

confidence: 99%

Sublingual microcirculatory alterations in cirrhotic patients

et al. 2018

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Cirrhosis is associated with microcirculatory alterations that can be easily monitored in the sublingual mucosa. Alterations included decreased density and PPV and hyperdynamic microvessels. The most striking finding, however, was the microvascular heterogeneity. Patients with spider angiomas had more severe alterations. Larger studies should clarify the relationship between microcirculatory abnormalities and outcome.

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The Effects of Arterial Hypertension and Age on the Sublingual Microcirculation of Healthy Volunteers and Outpatients with Cardiovascular Risk Factors

Abstract: Preexistent chronic arterial hypertension was associated with lower vascular densities. In contrast, age showed no effect on sublingual microcirculation.

Cited by 28 publications

References 47 publications

Effects of age, sex, and blood pressure on the blood flow velocity in dental pulp measured by Doppler ultrasound technique

Effects of age, sex, and blood pressure on the blood flow velocity in dental pulp measured by Doppler ultrasound technique

Recruitment of non‐perfused sublingual capillaries increases microcirculatory oxygen extraction capacity throughout ascent to 7126 m

Sublingual microcirculatory alterations in cirrhotic patients

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