The Effects of Aqueous Extracts of &amp;lt;i&amp;gt;Acalypha wilkesiana&amp;lt;/i&amp;gt; Supplementation and Exercise Training on Hematopoietic System in Rats

Ehiaghe, Alfred F.; Ehiaghe, Joy I.; Bright, Igere E.; Roland, Iyen I.

doi:10.4236/ajps.2013.49225

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…This is in accordance with the findings of Scott (2011),where cortisol is released in response to stressful events, coupled with the diversion of glucose from low priority organs in other to regain homeostasis .Cortisol prevents the proliferation of T cells by rendering the interleukin 2 producer Tcells unresponsive to interleukin -1 and unable to produce the T cell growth factor (Palacious and Sugawera 1982) and inhibits immunoglobulin A and immunoglobulin M in serum (Posey et. al., 1978).The immune system is merely responding to the effect of stressor, during which most of the adaptation leads to greater fitness, if balance diet and resting are observed (Ehiaghe et. al., 2013).…”

Section: Discussionmentioning

confidence: 99%

Effect of stress of examination on serum cortisol level and cd4 cell count in male undergraduates at Igbinedion University, Nigeria

Ehiaghe¹,

K.A²,

Ij³

2014

Afr. J. Cell. Path

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Aim:To assess the effect of stress of examination on serum cortisol level and CD4 cell count in young male students at Igbinedion University. Methods: A cross sectional laboratory based analysis was adopted for this study. A total of 204 male undergraduate volunteers (age 22 + 1.0 years, body mass index 23 + 0.5 kg/m 2 ) were randomly recruited for the study. Total white blood cell (TWBC) was determined using the sysmex® Automated Hematology Analyzer. CD4 cell count was estimated using Partec cyflow counter, while serum cortisol level was determined by enzyme linked immuno sorbent assay technique. Results: There was a significant increase (P < 0.05) in the serum cortisol level at Stage A (1 st day of the semester) when compared with Stage B (midway in the semester) and Stage C (morning of the examination), while there was significant decrease (P < 0.05) in the TWBC count and CD4 cell count at Stage A when compared with Stage B and Stage C. Conclusion: The stress of examination inhibits proliferation of CD4 cells with the elevation of serum cortisol as a possible mediator.

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Section: Discussionmentioning

confidence: 99%

Effect of stress of examination on serum cortisol level and cd4 cell count in male undergraduates at Igbinedion University, Nigeria

Ehiaghe¹,

K.A²,

Ij³

2014

Afr. J. Cell. Path

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“…Enzyme-linked immunosorbent assay was used in the determination of the level of serum cortisol in the serum as previously been described Ehiaghe et al [11]. In brief, 20 µl of standard or sample (s) was added per microplates.…”

Section: Determination Of Serum Cortisol Levelmentioning

confidence: 99%

The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise

Alfred¹

2017

IJI

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This study was designed to determine the expression patterns of some pro-inflammatory and anti-inflammatory cytokine genes in some young male undergraduates that passed through exhaustive exercise using the Bruce protocol for submaximal acute exercise as studies have shown that exhaustive exercise activates the release of multiple cytokine genes which modulate the immune responses of stressed individuals. Twenty five (25) healthy young male undergraduates with an average age of 24.3±3 years and body mass index of 22.7±1.8 (Kg/m 2) participated fully in the study. Blood samples were collected from the participants before commencement of the study, at 1 hour, 4 hours and 24 hours post exercise. Tumor necrosis factor α, interferon gamma and interleukin-10 genes expression patterns were detected using reverse transcriptase polymerase chain reaction methods. Serum cortisol (nmol/L) using enzyme-linked immunosorbent assay method. The study revealed that eleven (11) out of the twenty-five (25) participants had their tumor necrosis factor α genes up-regulated at 1 hour post exercise and sustained till 24 hours post exercise. Moreover, interferon gamma and interleukin-10 genes were up-regulated at 4 hours post exercise and sustained till 24 hours post exercise in most of the subjects. This study also observed that the cortisol level of the exercised subjects was significantly higher at 1 hour post acute exercise when compared with pre-exercise stage. Acute exercise was associated with an enhanced lymphocytic cell functions which are evidence in the up-regulation patterns of both lymphocytic pro-inflammatory cytokine and anti-inflammatory cytokine genes post exercise.

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Vascular and bone marrow explant models to assess in vitro hematotoxicity of herbal extracts

Rummun

Rybtsov

Bahorun

et al. 2020

Biodiversity and Biomedicine

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The Effects of Aqueous Extracts of <i>Acalypha wilkesiana</i> Supplementation and Exercise Training on Hematopoietic System in Rats

Abstract: The aim of this study is to compare the effects of single and combined oral administration of fresh aqueous extracts of Acalypha wilkesiana supplementation at 300 mg/ml and exercise training on some immuno indicator parameters in Rats.

Cited by 4 publications

References 18 publications

Effect of stress of examination on serum cortisol level and cd4 cell count in male undergraduates at Igbinedion University, Nigeria

Effect of stress of examination on serum cortisol level and cd4 cell count in male undergraduates at Igbinedion University, Nigeria

The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise

Vascular and bone marrow explant models to assess in vitro hematotoxicity of herbal extracts

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