The effects of anti‐hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity

Djukić, LJ; Roganović, Jelena; Brajović,; Bokonjić, Dubravko; Stojić, Dragica Lj.

doi:10.1111/odi.12325

Cited by 24 publications

(19 citation statements)

References 40 publications

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“…On the other hand, no differences were found between the subgroup of apparently healthy subjects (without drug treatment) and the subgroup receiving pharmacotherapy with regard to TAC/UA parameters. The use of anti-hypertensives or the presence of diabetes mellitus type 2 have been found to have little effect on salivary TAC in the few previous studies in this area [37,38].…”

Section: Discussionmentioning

confidence: 88%

A comparison of native and non-urate Total Antioxidant Capacity of fasting plasma and saliva among middle-aged and older subjects

et al. 2017

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Section: Discussionmentioning

confidence: 88%

A comparison of native and non-urate Total Antioxidant Capacity of fasting plasma and saliva among middle-aged and older subjects

et al. 2017

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“…Djukic et al (16) showed in a population of 387 hypertensive subjects that hypertension combined to diabetes promoted a significant salivary flow rate decrease that was dependent of the type of anti-hypertensive drug administrated during the treatment. In our data, salivary flow rate was also significantly different for diabetic patients (DM or DM+HAS group), which had salivary flow levels lower than 0.7 mL/min, while control and HAS individuals had normal flow condition (1-3 mL/min).…”

Section: Tgfβ1 In Diabetic and Hypertensive Patientsmentioning

confidence: 99%

Effects of Diabetes and Hypertension on Oral Mucosa and TGFβ1 Salivary Levels

et al. 2018

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in this cross-sectional study, whole stimulated saliva and oral mucosa exfoliative cytology specimens were collected from 39 patients that were healthy (control, n=10) or presented history of arterial hypertension (HAS, n=9), diabetes mellitus (DM, n=10) or both (DM+HAS, n=10). Salivary flow rate (SFR), TGFβ1 level in saliva, AgNORs and the epithelial maturation were evaluated. Non-parametric Kruskal-Wallis test, followed by Dunn's multiple comparison post-test and the Spearman test correlation analysis were used. SFR showed a significant decreased in DM and DM+HAS (0.47±0.11 and 0.64±0.43 mL/min) when compared to control (1.4±0.38 mL/min). DM+HAS presented the highest value of TGFβ1 concentration (24.72±5.89 pg/mL). It was observed a positive correlation between TGFβ1 and glycaemia (R=0.6371; p<0.001) and a negative correlation between TGFβ1 and saliva (R=-0.6162; p<0.001) and glycaemia and SFR (R=-0.5654; P=0.001). AgNORs number and status of maturation of mucosa cells were similar for all conditions. DM and DM+HAS presented the lowest SFR, which correlated with increased TGFβ1 levels. Despite the higher TGFβ1 secretion it was not observed changes in the morphology or proliferation of epithelial cells when diabetes or hypertension was present.

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“…This review showed that the most frequent oral ADR is xerostomia, and the most reported culprit drugs with significant results are antihypertensive medications (18,19).…”

Section: Resultsmentioning

confidence: 99%

“…In this study, the researchers unraveled that enalapril is an independent factor which is well capable of moderately reducing the risk of development of xerostomia; while with sharp contrast metoprolol is an independent risk factor for development of xerostomia. More impressive, combinations of enalapril with metoprolol and/or hydrochlorothiazide are not independent risk factors (19).…”

Section: Xerostomia and Hyposalivationmentioning

confidence: 99%

An Update on Drug-induced Oral Reactions

Yousefi¹,

Abdollahi²

2018

J Pharm Pharm Sci

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-Adverse drug reactions (ADRs) are one of the major culprits in the development of oral lesions, which can be misdiagnosed with underlying diseases. The goal of this study is to summarize and update the current knowledge about drug-induced oral reactions. Electronic searches were performed in Scopus, Google Scholar, Cochrane and PubMed databases, for articles published between January 2008 and August 2017. Two authors screened the titles and abstracts for eligibility. Finally, 56 studies included in this review. There was no systematic homogeneity in the included studies; thereby no meta-analysis was performed. The most frequent oral ADR was xerostomia, and the most reported cause was antihypertensive medications. Cardiovascular drugs were the most reported culprit agents for induction of oral ulcerative and vesiculo-bullous lesions, followed by methotrexate. Nonsteroidal anti-inflammatory drugs (NSAIDs) and β-blockers were found the most common responsible drugs for induction of oral lichen planus.

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The effects of anti‐hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity

Cited by 24 publications

References 40 publications

A comparison of native and non-urate Total Antioxidant Capacity of fasting plasma and saliva among middle-aged and older subjects

A comparison of native and non-urate Total Antioxidant Capacity of fasting plasma and saliva among middle-aged and older subjects

Effects of Diabetes and Hypertension on Oral Mucosa and TGFβ1 Salivary Levels

An Update on Drug-induced Oral Reactions

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