The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendon

Karpakka, Jarmo; Pesola, Maija K.; Takala, Tuomo

doi:10.1097/00042752-199210000-00026

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Steroid injection is frequently associated with rupture of tendons (Stannard and Bucknell 1993) and ligaments as well (Freeman and Rooker 1995). AAS treatment also compromises collagen synthesis in both muscle and tendon, with the former requiring lower doses (Karpakka et al 1992).…”

Section: Introductionmentioning

confidence: 99%

Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids

et al. 2008

View full text Add to dashboard Cite

Matrix metallopeptidases (MMPs) are responsible for degradation of the extracellular matrix components and tissue remodeling. To achieve a better understanding of AAS effects in rat tendon, MMP-2 activity in the proximal and distal regions of the calcanear tendon (CT) and proximal, intermediate and distal region of superficial (SFT) and deep flexor tendons (DFT) after mechanical load exercise associated with AAS was investigated. Animals were grouped into four groups: sedentary animals (S); sedentary animals with ASS supplementation (S + A); trained animals (T) and trained animals with AAS supplementation (T + A). Analysis of MMP activity in tendon extracts was done by gelatin zymography. Both proximal and distal regions of the calcanear tendon showed the lowest MMP-2 concentration and the highest proportion in MMP-2 active form. The intermediate region of the SFT differed (P < 0.01) from the proximal and distal regions with higher % of active MMP-2 in the sedentary group. The proportion of active MMP-2 decreased in the proximal region of the CT. AAS treatment strongly decreased both MMP-2 concentration and active form in the three regions of the SFT and on the proximal region of the CT, but not on the DFT. The differences in the response to exercise and AAS treatment are a result of distinct metabolism and recruitment of these tendon regions in the exercise program employed in this study.

show abstract

Section: Introductionmentioning

confidence: 99%

Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids

et al. 2008

View full text Add to dashboard Cite

show abstract

“…16 Biosynthesis of collagen in the rat tendon may be affected by high doses of AAS. 17 The use of AAS combined with exercise (treadmill) in one study induced an increase in stiffness and a decrease in both elongation and energy absorption. 16 There are some reports of increased tendon damage in anabolic steroid abusers, mostly involving power lifters.…”

mentioning

confidence: 99%

Androgenic-Anabolic Steroids Associated with Mechanical Loading Inhibit Matrix Metallopeptidase Activity and Affect the Remodeling of the Achilles Tendon in Rats

et al. 2006

View full text Add to dashboard Cite

show abstract

The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendon

Cited by 2 publications

References 0 publications

Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids

Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids

Androgenic-Anabolic Steroids Associated with Mechanical Loading Inhibit Matrix Metallopeptidase Activity and Affect the Remodeling of the Achilles Tendon in Rats

Contact Info

Product

Resources

About