The Effects of an Inhaled β2-Adrenergic Agonist on Lower Esophageal Function

Crowell, Michael D.; Zayat, Estephan N.; Lacy, Brian E.; Schettler-Duncan, Ann; Liu, Mark C.

doi:10.1378/chest.120.4.1184

Cited by 115 publications

(69 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These, in combination with the use of medication, e.g. theophylline and b 2 -agonists which may decrease the lower oesophageal sphincter pressure, could facilitate reflux of gastric content [16,17].…”

mentioning

confidence: 99%

Increased gastro-oesophageal reflux disease in patients with severe COPD

Casanova¹,

Baudet²,

Velasco³

et al. 2004

Eur Respir J

150

126

View full text Add to dashboard Cite

The prevalence and clinical consequences of gastro-oesophageal reflux disease (GERD) in chronic obstructive pulmonary disease (COPD) are not well characterised.The present study prospectively studied 42 males with COPD (forced expiratory volume in one second % predicted: 35%, range 20-49) and 16 healthy volunteers of similar age without respiratory or gastro-oesophageal symptoms. The diagnosis of GERD was confirmed using oesophageal 24 h pH monitoring. In the current study group, reflux symptoms were measured using the Vigneri score, cough and dyspnoea with the modified Medical Research Council questionnaire, and pulmonary function with bronchodilator response and health status using St George9s Respiratory Questionnaire.Pathological reflux was documented in 26 out of 42 patients (62%) and in three volunteers (19%). In patients with GERD, 15 patients (58%) did not report any reflux symptoms. There were no differences in symptoms, health status, bronchodilator treatment and pulmonary function test between patients with and without GERD. Oxygen desaturation coincided with episodes of increased oesophageal acidity in 40% of patients with GERD.Patients with severe chronic obstructive pulmonary disease have a high prevalence of asymptomatic gastro-oesophageal reflux. The association between this reflux and oxygen desaturation deserves further attention. Eur Respir J 2004; 23: 841-845.

show abstract

mentioning

confidence: 99%

Increased gastro-oesophageal reflux disease in patients with severe COPD

Casanova¹,

Baudet²,

Velasco³

et al. 2004

Eur Respir J

150

126

View full text Add to dashboard Cite

show abstract

“…Predisposition factors of reflux occurring in patients with asthma generally include: weakened the lower esophageal sphincter (LES)-barrier by an increased negative pressure in the thorax, autonomic dysregulation with heightened vagal tone, transient LES relaxations (TLESRs) due to airway obstruction and reduction of LES pressure by asthma medications e.g. β2-adrenergic agonists [4][5][6].…”

Section: Etiopathogenesismentioning

confidence: 99%

Laryngopharyngeal Reflux and Asthma

DembiÅski¹,

Aleks²,

Banaszkiewicz³

et al. 2013

J Allergy Ther

View full text Add to dashboard Cite

The gastroesophageal reflux presence in asthma has been the subject of many studies indicating their frequent coexisting. The essence of this correlation is not entirely clear and several hypotheses can be found in literature. Recently defined laryngopharyngeal reflux and studies on its impact on the course of asthma seem to bring us closer to understanding this issue. In the last years we gained access to the new diagnostic methods allowing direct registration of laryngopharyngeal reflux. This paper summarizes laryngopharyngeal reflux diagnostic possibilities including the most advanced technologies. It also evaluates published clinical studies, which investigated laryngopharyngeal reflux in asthma patients, both in adults and children. Journal of Allergy & Therapy Journ a l o f A llergy & T h e ra py ISSN: 2155-6121Citation: Dembiński Ł, Banaszkiewicz A, Albrecht P (2013) Laryngopharyngeal Reflux and Asthma. J Aller Ther S11: 008.

show abstract

“…Inhaled bronchodilators may increase the risk of gastroesophageal reflux, due to a dose-dependent relaxation of the lower esophageal sphincter, which facilitates upward movement of stomach acids. 26 A proposed mechanism is that much of the "inhaled" dose is swallowed, which relaxes smooth muscle in the digestive tract. 27 Oral corticosteroids may increase gastroesophageal reflux and associated symptoms due to increased esophageal acid contact time.…”

Section: Potential Treatment Errors and Consequencesmentioning

confidence: 99%

Can Reactive Airways Dysfunction Syndrome (RADS) Be Iatrogenic?

Hewitt¹

2011

Respir Care

View full text Add to dashboard Cite

Reactive airways dysfunction syndrome (RADS) is an asthma-like illness that develops after a single high-level exposure to a pulmonary irritant. Two different cases are reviewed, in which the exposure circumstances were not sufficient to result in adverse health effects yet resulted in persistent respiratory symptoms and a clinical diagnosis of RADS. Potential explanations for an erroneous diagnosis of RADS included an incomplete exposure assessment, medication adverse effects that can contribute to respiratory symptoms, and alternative explanations for respiratory symptoms or test findings. In particular, the empirical use of bronchodilator medications without a clear indication appeared to contribute to continued respiratory symptoms. Without a clear understanding of the patient's exposure, a RADS diagnosis should be carefully considered. The possibility of an iatrogenic sequence of events in which medication adverse effects facilitate respiratory symptoms and a mistaken RADS diagnosis should be considered, particularly in patients who have a poorly defined exposure history.

show abstract

The Effects of an Inhaled β2-Adrenergic Agonist on Lower Esophageal Function

Cited by 115 publications

References 24 publications

Increased gastro-oesophageal reflux disease in patients with severe COPD

Increased gastro-oesophageal reflux disease in patients with severe COPD

Laryngopharyngeal Reflux and Asthma

Can Reactive Airways Dysfunction Syndrome (RADS) Be Iatrogenic?

Contact Info

Product

Resources

About