The effects of an additive small amount of a low residual diet against total parenteral nutrition–induced gut mucosal barrier

Ohta, Kouji; Omura, Kenji; Hirano, Kathuyasu; Kanehira, Eiji; Ishikawa, Nobuhiro; Kato, Yosuke; Kawakami, Kazuyuki; Watanabe, Go

doi:10.1016/s0002-9610(02)01108-x

Cited by 46 publications

(39 citation statements)

References 21 publications

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“…21 In rats, IgA-positive cells decreased in a dose-dependent fashion when PN increased, and enteral nutrition decreased resulting in increased intestinal permeability. 20 A minor intake of enteral nutrition prevented mucosal atrophy. 20 Parenteral nutrition may also result in lower levels of IL-4 and IL-10 6 and increased expression of interferon-g (IFNg).…”

Section: Discussionmentioning

confidence: 99%

“…20 A minor intake of enteral nutrition prevented mucosal atrophy. 20 Parenteral nutrition may also result in lower levels of IL-4 and IL-10 6 and increased expression of interferon-g (IFNg). 22 IL-4 and IL-10 belong to the Th2 response, which may play an important role in the regulation of GVHD.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 IgA also plays an important role in gut immune defences primarily by preventing the attachment of bacteria to the mucosal cells of the gut. 21 In rats, IgA-positive cells decreased in a dose-dependent fashion when PN increased, and enteral nutrition decreased resulting in increased intestinal permeability.…”

Section: Discussionmentioning

confidence: 99%

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Poor oral nutrition after allogeneic stem cell transplantation correlates significantly with severe graft-versus-host disease

Mattsson

Westin

Edlund

et al. 2006

Bone Marrow Transplant

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Poor oral nutrition after allogeneic stem cell transplantation correlates significantly with severe graft-versus-host disease

Mattsson

Westin

Edlund

et al. 2006

Bone Marrow Transplant

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“…Here, the experimental diets contained fibre and starch. This might have provided the minimal energy and load necessary for restoring intestinal atrophy observed in rats on total parenteral nutrition [34]. Studies with neonatal pigs have also shown that the minimal enteral nutrient intake necessary to increase mucosal mass is close to 40% of total nutrient intake [35].…”

Section: Discussionmentioning

confidence: 99%

“…Milk replacers for calves contain high levels of lactose and fat, combined with low levels of starch and no fibre. These highly digestible diets, when they are protein free, are most probably completely digested in the proximal small intestine [5], with a resulting median to distal villus-crypt atrophy, as seen in models of total parenteral nutrition [33,34]. Here, the experimental diets contained fibre and starch.…”

Section: Discussionmentioning

confidence: 99%

A protein-free diet alters small intestinal architecture and digestive enzyme activities in rats

2006

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-The consequences of feeding a protein-free (PF) diet, as compared to casein, on gut characteristics were studied in slightly energy-restricted rats fed similar amounts of feed for 10 d. The weight and pH of fresh digesta in the stomach were lower (P = 0.045 and P = 0.016). However, the weight of fresh digesta in the other segments and gut tissue weight were not significantly affected by the diet (P > 0.05). Small intestinal crypt depth, width and area were reduced by 13, 23 and 37%, respectively (P = 0.011, P = 0.004 and P = 0.001), and villus width tended to be smaller (P = 0.057), with the PF diet. Villus height to crypt depth ratio was also lower with the PF diet in the duodenum and ileum, respectively (P < 0.05). Finally, the specific activities of alkaline phosphatase and aminopeptidase N were reduced by 36 to 38% at different sites of the small intestine in the rats fed the PF diet (P < 0.05). In conclusion, chronic consumption of a protein-free diet altered the intestinal villus-crypt architecture and enzyme activities in rats.rat / protein-free diet / intestine / villus-crypt architecture / enzyme

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Indications and Patterns of Use for Parenteral Nutrition in Pediatric Oncology

McGrath

Evans

Yap

2019

J Parenter Enteral Nutr

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Background: Children with cancer are at risk of treatment related gastrointestinal toxicity and malnutrition. Intestinal dysfunction may preclude or limit use of enteral nutrition, and parenteral nutrition (PN) may be required. Published indications for PN use in children with cancer are generally nonspecific. We sought to describe patterns of use, indications, and frequency of PN prescription in children with cancer and propose indicators to guide appropriate PN use. Methods: Retrospective chart review of children with cancer receiving inpatient PN in a tertiary referral pediatric hospital over 12 months was performed using electronic medical record search and paper records. Data were summarized using descriptive statistics. Results: PN was prescribed to 88 patients in 111 episodes. Total use (2377 days) represented 24% of annual inpatient days in all children with cancer. Primary clinical indications were mucositis (40%), feed intolerance (29%), postoperative (16%), or "other" (15%), (including nasogastric tube refusal (n = 6)). Patients with hematological cancer had longer median episodes (19 vs 12.5 days) and earlier commencement of PN after diagnosis (50 vs 80 days) than children with nonhematological cancer. Most PN episodes longer than 28 days were in children with hematopoietic stem cell transplant (HSCT). Conclusion: Inpatient PN use is common in childhood cancer. Indications include mucositis, feed intolerance, and surgical management. Patterns of use are influenced by cancer diagnosis and treatment, with greater use in children with hematological cancer and HSCT. Improved understanding and specific indications may guide appropriate PN prescription and minimize unnecessary risk, cost, and inconsistency in care.

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The effects of an additive small amount of a low residual diet against total parenteral nutrition–induced gut mucosal barrier

Cited by 46 publications

References 21 publications

Poor oral nutrition after allogeneic stem cell transplantation correlates significantly with severe graft-versus-host disease

Poor oral nutrition after allogeneic stem cell transplantation correlates significantly with severe graft-versus-host disease

A protein-free diet alters small intestinal architecture and digestive enzyme activities in rats

Indications and Patterns of Use for Parenteral Nutrition in Pediatric Oncology

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