The Effects of <i>Sida corymbosa</i> Leaf Extract Against Abnormal Bilirubin and Total Protein in Albino Rats by Carbon Tetrachloride (CCl<sub>4</sub>)

Abstract

The Sida corymbosa plant has been used for centuries in traditional medicine in different countries for prevention and treatment of different diseases such as liver and cardiac diseases. This work aimed at investigating if Sida corymbosa ethanolic leaf extract has preventive and therapeutic effects against abnormal serum bilirubin and total protein in Albino rats by carbon tetrachloride (CCl 4

Effects of Sida corymbosa Leaf-Extract on the Lipid Profile of Carbon Tetrachloride-Injected Male Rats

“…The LD50 of the ethanol-leaf extract of Sida corymbosa plant has been determined by Dike et al, [13], to be above 5000 mg/kgBW and confirmed according to [17] by administering 5, 000 mg/kgbw of the ethanol extract to each of two groups of one rat each. The observation was carried out on the rats for 1h after administration and 10 min for every 2 h interval for 24 h.…”

“…Carbon tetrachloride is a well-known model for inducing toxicities in human and other animals [9], including rats. Carbon tetrachloride had been reported to cause metabolic disorders which include abnormal lipid profile in experimental rats [10].…”

“…According to Dike [9][10], Okonkwo [11], the use of medicinal plants in the treatment of diseases has been ongoing in various parts of Africa, including Nigeria and some parts of Asia. There are many trees and shrubs in Nigeria with many medicinal and nutritional values [12].…”