The Effects of Aminophylline on Sleep and Sleep-Disordered Breathing in Patients with Obstructive Sleep Apnea Syndrome

Espinoza, Hugo; Antić, R; At, Thornton; Rd, McEvoy

doi:10.1164/ajrccm/136.1.80

Cited by 62 publications

(21 citation statements)

References 4 publications

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“…It must be pointed out, that Theophylline does not influence mean and minimal O 2 ‐saturations during sleep in patients with SAS [15]. However, sleep architecture and sleep quality can be disturbed.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Effect of Theophylline on Sustained Attention in Patients with Obstructive Sleep Apnea. Die Wirkung von Theophyllin auf die Daueraufmerksamkeit von Patienten mit OSAS

Büttner

Rühle

2003

Somnologie

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Summary Question of the Study Patients with obstructive sleep apnea syndrome (OSAS) often suffer from daytime sleepiness and reduced alertness which frequently cannot be normalized despite of nCPAP therapy. Therefore additional treatment options for residual deficits is urgently needed. The objective of this study was to prove the efficacy of Theophylline on a component of attention (tracking) in patients with untreated obstructive sleep apnea syndrome (OSAS).  Patients and Methods Theophylline or placebo was given two times in the morning (8:00 and 12:00 a. m.) in randomized order on two consecutive days. During the afternoon, 39 OSAS patients performed a randomised cross‐over driving simulation test with the aid of “Carsim”, a newly developed driving simulator, prior to undergoing CPAP‐ therapy. The program “Carsim” simulates a road with curves on a screen, the simulated vehicle should be kept on the right lane by moving the steering wheel.  Results Under the effect of Theophylline (the serum level under placebo at the beginning of the measurement was 2.1 µg/ml ± 1.6 µg/ml and under Theopylline 11.2 µg/ml ± 2.8 µg/ml), the duration of track deviations measured by the driving simulator improved significantly from 49.3 ± 99.5 s to 13.6 ± 18.0 s.  Conclusions Theophylline may improve alertness in patients with sleep fragmentation and reduced sustained attention.

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Section: Discussionmentioning

confidence: 99%

The Therapeutic Effect of Theophylline on Sustained Attention in Patients with Obstructive Sleep Apnea. Die Wirkung von Theophyllin auf die Daueraufmerksamkeit von Patienten mit OSAS

Büttner

Rühle

2003

Somnologie

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“…The effect of a single night of intravenous aminophylline, a methylxanthine known to have respiratory stimulant properties, on OSA severity in 10 patients was investigated in a crossover, single-blind, randomised, placebo-controlled study [53]. There was no change in either frequency or duration of obstructive apnoeas.…”

Section: Drugs Proposed To Act On Ventilatory Drive 331 Aminophyllimentioning

confidence: 99%

Pharmacological approaches to the treatment of obstructive sleep apnoea

Kohler

Bloch

Stradling

2009

Expert Opinion on Investigational Drugs

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ChooseBackground: Currently the treatment of choice for symptomatic obstructive sleep apnoea (OSA) is continuous positive airway pressure (CPAP). Some patients with OSA do not tolerate CPAP or have insufficiently severe symptoms to justify its use; for these patients, drug therapy would be a desirable potential therapeutic alternative. Objective: To summarize the current evidence on the effectiveness of drug therapy in patients with OSA. Methods: A systematic review of randomized controlled trials was performed to investigate the effects of drug therapy on OSA. Results/conclusions: Searches of bibliographical databases revealed 33 trials investigating the effects of 27 different drugs on OSA severity and/or symptoms. The mechanisms by which these drugs are supposed to improve OSA include, amongst others, an increase in tone of the upper airways, an increase in ventilatory drive, a reduction in airway resistance, and alterations in surface tension forces in the upper airway. In most of these studies there was no significant effect on OSA observed. However, there is evidence from a few small trials that some drugs, especially those thought to increase upper airway muscle tone, have the potential to reduce OSA severity; but further data from larger studies of adequate duration are needed.

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“…Studien mit verwertbaren, aber widersprüchlichen Ergebnissen in der Therapie der obstruktiven Schlafapnoe liegen an größeren Patientenzahlen nur für Theophyllin vor [10,12,49]. Es wird lediglich in den deutschsprachigen Län- [31].…”

Section: Apparativ-prothetische Therapieunclassified

Diagnostik und Therapie von schlafbezogenen Atmungsstörungen

Maurer

Hörmann

1998

HNO

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ENT specialists are now being asked for help by increasing numbers of snoring patients who complain about nocturnal apnea and excessive daytime sleepiness. A final diagnosis is often made in a sleep disorders center. Sleep medicine has emerged as a new inter-disciplinary specialty during the last decade, although otorhinolaryngologists commonly are unable to fully interpret clinical findings. This report discusses the terms and information often detailed at a sleep disorders center. The evaluation of diagnostic and therapeutic procedures is explained.

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The Effects of Aminophylline on Sleep and Sleep-Disordered Breathing in Patients with Obstructive Sleep Apnea Syndrome

Cited by 62 publications

References 4 publications

The Therapeutic Effect of Theophylline on Sustained Attention in Patients with Obstructive Sleep Apnea. Die Wirkung von Theophyllin auf die Daueraufmerksamkeit von Patienten mit OSAS

The Therapeutic Effect of Theophylline on Sustained Attention in Patients with Obstructive Sleep Apnea. Die Wirkung von Theophyllin auf die Daueraufmerksamkeit von Patienten mit OSAS

Pharmacological approaches to the treatment of obstructive sleep apnoea

Diagnostik und Therapie von schlafbezogenen Atmungsstörungen

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