The Effects of Alterations in Nitric Oxide Levels in the Paraventricular Nucleus on Copulatory Behavior and Reflexive Erections in Male Rats

Sato, Yoshikazu; Christ, George J.; Horita, Hiroki; Adachi, Hideki; Suzuki, Noriyoshi; Tsukamoto, Taiji

doi:10.1016/s0022-5347(05)68156-6

Cited by 53 publications

(33 citation statements)

References 18 publications

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“…Thus, although NO appears to be important for the initial acquisition of copulatory behavior, it may not be an absolute requirement for its maintenance. However, even sexually experienced rats in this and other studies have shown sexual deficits with systemically (Benelli et al, 1995;Bialy et al, 1996;Hull et al, 1994) or centrally (Melis et al, 1998;Sato et al, 1998Sato et al, , 1999 administered NOS inhibitors.…”

Section: Discussionmentioning

confidence: 46%

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Lagoda

Muschamp

Vigdorchik

et al. 2004

Behavioral Neuroscience

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Dopamine in the medial preoptic area (MPOA) facilitates copulation in male rats, and nitric oxide (NO) regulates basal and female-stimulated MPOA dopamine release. Microinjection of L-nitro-arginine methyl ester (L-NAME, an NO synthesis inhibitor) into the MPOA blocked copulation in naive rats and impaired copulation in sexually experienced males. In other naive rats, L-NAME or saline was microinjected into the MPOA before each of 7 daily exposures to a receptive female placed over their cage. In a drug-free test on Day 8, copulation by L-NAME-treated rats was similar to that of unexposed controls and was impaired relative to saline-treated males. Therefore, NO in the MPOA is important for copulation and stimulus sensitization in male rats.

show abstract

Section: Discussionmentioning

confidence: 46%

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Lagoda

Muschamp

Vigdorchik

et al. 2004

Behavioral Neuroscience

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show abstract

“…Direct measurements of NO in the MPOA showed NO release associated with copulatory behavior. Local administration of a NOS inhibitor decreased NO release and copulatory behavior (Sato et al, 1998(Sato et al, , 1999. NO production increased in the PVN during noncontact erection and copulation .…”

Section: Nitric Oxidementioning

confidence: 97%

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

2011

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“…16,34 ± 37 NO may act in several discrete brain regions, eg in the medial preoptic area 36,37 as well as in the paraventricular nucleus. 9,16 Injection of NOS inhibitors intracerebroventricularly or in the paraventricular nucleus prevented penile erectile responses induced by dopamine agonists, oxytocin, and NMDA in rats.…”

Section: Opioid Peptidesmentioning

confidence: 99%

Neurotransmitters: central and peripheral mechanisms

2000

Int J Impot Res

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Re¯exive erection initiated by recruitment of penile afferents, involves both autonomic and somatic efferents. The re¯ex is mediated at the spinal cord level, modulated by supraspinal in¯uences, and may use several transmitters. Dopamine, acetylcholine, nitric oxide, and peptides, such as oxytocin and ACTHaa-MSH, seem to have a facilitatory role, whereas serotonin may be either facilitatory or inhibitory, and enkephalins are inhibitory. Peripherally, the balance between contractant and relaxant factors controls the degree of contraction of the smooth muscle of the corpora cavernosa, and determines the functional state of the penis. Noradrenaline contracts both corpus cavernosum and penile vessels via stimulation of a 1 -adrenoceptors. The role of endothelins in the control of penile smooth muscle tone is presently unclear. Neurogenic nitric oxide (NO) is considered the most important factor for relaxation of penile vessels and corpus cavernosum. The role of other mediators, released from nerves or endothelium has not been de®nitely established.

show abstract

The Effects of Alterations in Nitric Oxide Levels in the Paraventricular Nucleus on Copulatory Behavior and Reflexive Erections in Male Rats

Cited by 53 publications

References 18 publications

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

Neurotransmitters: central and peripheral mechanisms

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