The effects of alcohol consumption on flow‐mediated dilation in humans: A systematic review

Hwang, Chueh‐Lung; Piano, Mariann R.; Phillips, Shane A.

doi:10.14814/phy2.14872

Cited by 9 publications

(9 citation statements)

References 66 publications

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“…A recent meta-analysis confirmed that long-term, heavy drinking is associated with abnormal FMD. 82 Fourth, the increased oxidative stress related to alcohol use has been shown to promote the generation of 20-hydroxyeicosatetraenoic acid (20-HETE), another vasoconstrictor. 80,[82][83][84] Fifth, alcohol directly causes release of endothelin-1 and endothelin-2 from vascular endothelial cells, further contributing to the vasoconstrictorvasodilator imbalance.…”

Section: Chronic Alcohol-related Hypertensionmentioning

confidence: 99%

“…82 Fourth, the increased oxidative stress related to alcohol use has been shown to promote the generation of 20-hydroxyeicosatetraenoic acid (20-HETE), another vasoconstrictor. 80,[82][83][84] Fifth, alcohol directly causes release of endothelin-1 and endothelin-2 from vascular endothelial cells, further contributing to the vasoconstrictorvasodilator imbalance. 85 Finally, alcohol-induced dysregulation of calcium cycling in vascular smooth muscle cells has been described, impairing vascular relaxation.…”

Section: Chronic Alcohol-related Hypertensionmentioning

confidence: 99%

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Drugs of Misuse: Focus on Vascular Dysfunction

Middlekauff

Cooper

Strauss

2022

Canadian Journal of Cardiology

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Section: Chronic Alcohol-related Hypertensionmentioning

confidence: 99%

Section: Chronic Alcohol-related Hypertensionmentioning

confidence: 99%

Drugs of Misuse: Focus on Vascular Dysfunction

Middlekauff

Cooper

Strauss

2022

Canadian Journal of Cardiology

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“…Therefore, alcohol-induced arterial stiffening may be related to endothelial dysfunction. Along with this possibility, our recent systemic review suggests that heavy alcohol consumption (≥ 3–5 drinks, daily or binge pattern) is associated with a decrease in brachial artery flow-mediated dilation [ 57 ], a non-invasive measure of endothelial function in humans.…”

Section: Mechanisms Of Alcohol-associated Changes In Arterial Stiffeningmentioning

confidence: 99%

Alcohol Consumption: A New Risk Factor for Arterial Stiffness?

et al. 2022

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The relationship between alcohol consumption and cardiovascular disease risk is complex. Low-to-moderate daily alcohol consumption (1–2 drinks/day) is associated with reduced risk, whereas greater amounts of alcohol consumption and a “binge” pattern of drinking are associated with increased cardiovascular risk and mortality. Arterial stiffness may help explain the complex relationship. This integrated review summarizes data from studies examining the associations between alcohol consumption and pulse wave velocity, a gold standard measure of arterial stiffness. We also briefly review the concept and methodology of pulse wave velocity measurement as well as the mechanisms of alcohol-induced arterial stiffening. Findings among the different studies reviewed were inconsistent with methodological challenges related to alcohol use assessment. While making specific conclusions regarding this relationship is tenuous; the data suggest that excessive alcohol consumption or a binge drinking pattern is associated with increased arterial stiffness.

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“…Endothelial dysfunction is observed in heavy [23] and even in some light alcohol consumers [24]. Given that alcohol use is also associated with AF [25] and both AF and alcohol are linked to endothelial dysfunction, it was possible that our findings of no differences in FMD in warfarin and apixaban groups was affected by significantly greater proportion of alcohol consumers and units of alcohol consumed per week in apixaban group.…”

Section: Discussionmentioning

confidence: 88%

Relationship of Warfarin and Apixaban with Vascular Function in Patients with Atrial Fibrillation

Junejo,

Gupta,

Snowdon

et al. 2024

J Vasc Res

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Introduction: Atrial fibrillation (AF) is associated with endothelial damage/dysfunction. Herein, we tested the hypothesis that brachial artery flow-mediated dilation (FMD) is superior in AF patients taking apixaban compared to warfarin. Methods: AF patients on apixaban (n = 46; 67 [7] years; mean [standard deviation]; 15 women) and warfarin (n = 27; 73 [9] years (p < 0.01); 11 women) were recruited. Duplex Doppler ultrasound imaging was undertaken during baseline (2 min), cuff inflation (5 min), and following cuff deflation (3 min). FMD was defined as peak increase in brachial artery diameter following cuff deflation and analysed as percentage change in diameter, as a ratio of FMD, shear rate area under the curve (SRAUC; FMD-to-SRAUC), and using SRAUC as a covariate (FMDSR). Results: Baseline artery diameter (4.96 [1.14] vs. 4.89 [0.88] mm), peak diameter (5.12 [1.17] vs. 5.14 [0.93] mm), and FMDSR (3.89 [3.62] vs. 4.80 [3.60] %) were not different between warfarin and apixaban (p > 0.05; analysis of covariance with age, CHA2DS2-VASc, years since AF diagnosis, number of diabetics, alcohol drinkers, and units of alcohol consumed per week as covariates). Stepwise multiple regression identified independent association of fibrillation, hypertension, and increased age with FMD. Conclusion: AF patients on warfarin and apixaban exhibit similar endothelium-dependent vasodilation. Increased blood pressure negatively impacts vasodilator capacity in AF patients.

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The effects of alcohol consumption on flow‐mediated dilation in humans: A systematic review

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 9 publications

References 66 publications

Drugs of Misuse: Focus on Vascular Dysfunction

Drugs of Misuse: Focus on Vascular Dysfunction

Alcohol Consumption: A New Risk Factor for Arterial Stiffness?

Relationship of Warfarin and Apixaban with Vascular Function in Patients with Atrial Fibrillation

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