The effects of air pollution and smoking on placental cadmium, zinc concentration and metallothionein expression

Sorkun, Hülya Çetin; Bir, Ferda; Akbulut, Metin; Divrikli, Ümit; Erken, Gülten; Demirhan, Huriye; Düzcan, Ender; Elçi, Latif; Çelik, İsmail; Yozgatlı, Unsal

doi:10.1016/j.tox.2007.05.020

Cited by 60 publications

(48 citation statements)

References 44 publications

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“…Noteworthy, recent evidence shows that normal pregnancy compared with non-pregnancy is a hypomethylated state that allows better maternal adaptation to the fetus [23], as well as that in distrubed pregnancies a widespread trend toward hypermethylation or hypomethylation of multiple genes in placenta might be found [38]. The latter include also the influences of prenatal and early postnatal nutrition [26], maternal smoking [39,40] and exposure of mother to various toxic substances during the pregnancy [41][42][43]. Consistent with these proposals, recently it was found that Zn deficiency in utero might induce fetal epigenetic alterations of mouse metallothionein-2 gene and that these changes might be stored as an epigenetic memory until adulthood [26].…”

Section: Discussionmentioning

confidence: 99%

“…1B). since in different models it has been shown that overproduction of placental MTs, induced by highly toxic environmental pollutant, such as smoking, mercury vapor, cadmium, lead, arsen etc [35][36][37][38][39][40], might be associated to detrimental effects on fetal growth and development. In this conditions MTs assist in the trapping and elimination of injurious toxic metals, but as shown in smokers, this may induce also the retention of zinc and its lower transference to the fetus [69].…”

Section: Discussionmentioning

confidence: 99%

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Expression of Metallothioneins in Placental and Fetal Tissues in Undisturbed and PGM-Zn Treated Syngeneic Pregnancy

Jakovac¹,

Grebić²,

Mrakovčić-Šutić³

et al. 2015

AJBIO

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Metallothioneins (MTs) are cysteine-rich proteins, which have been implicated in regulation of physiological processes, such as cell growth, repair, differentiation, apoptosis and immunoregulation, as well as in the protection against heavy metals, oxidant damages, inflammation and other stressful conditions. To investigate their roles in physiological and detoxification processes at the maternal-fetal interface and in fetal organogenesis we examined the tissue expression of MT I/II isoforms in undisturbed syngeneic pregnancy and after the treatment with peptidoglycan monomer linked with zinc (PGM-Zn). The data showed that in undisturbed pregnancy the MTs were highly expressed at junctional zone of placenta, on endovascular trophoblast giant cells, glycogen cells and spongiotrophoblast cells, as well as on villous trophoblast cells. In the fetus they were found predominantly in the liver and in epithelial tissues, such as intestine, pancreas and kidney. Treatment with PGM-Zn markedly enhanced the intensity of MT staining both at the maternal-fetal interface and in fetal organs. The data imply that MTs are involved in the protection of trophoblast cells against the pregnancy-induced deregulation of redox and neuro-immuno-endocrine homeostasis, in transport and storage of essential metals required for fetal organogenesis, as well as in the protection of fetus against bacterial toxins.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Expression of Metallothioneins in Placental and Fetal Tissues in Undisturbed and PGM-Zn Treated Syngeneic Pregnancy

Jakovac¹,

Grebić²,

Mrakovčić-Šutić³

et al. 2015

AJBIO

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“…However, other organs including placenta have been reported to retain Cd which is used as indicator organ for Cd exposure (Bush et al, 2000;Osman et al;Sorkun et al). Interestingly, all pregnant women who had high P-Cd level also reside in Mae Ku, Mae Tao and PrathatPhadeang where were reported as high Cd-contaminated areas (Simmons et al).…”

Section: Discussionmentioning

confidence: 99%

“…However, placenta is considered as an indicator organ for heavy metal exposure (Sorkun et al, 2007). Many studies revealed that Cd accumulation in human placenta involved in morphological changes of placenta and fetal development.…”

Section: Introductionmentioning

confidence: 99%

Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas

et al. 2013

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SUMMARY:A toxic metal, cadmium (Cd), can accumulate in human organs. Placenta is usually used as indicator organ for Cd exposure. Therefore, we aim to investigate the different of placental morphology between the low-and high-Cd accumulated placentas. The samples were collected from 14 pregnant women who resided in low-Cd contaminated (L-Cd group) and high-Cd contaminated (HCd group) areas. The concentrations of Cd in blood (B-Cd), urine (U-Cd) and placentas (P-Cd) were measured by ICP-MS and AAS. The morphological appearance of placentas was examined by using routine paraffin section and H & E staining. The results showed that levels of B-Cd, U-Cd and P-Cd were significantly higher in H-Cd group than in L-Cd group (p= 0.001). Moreover, the B-Cd was positively correlated with U-Cd (rs= 0.823, p= 0.000) and P-Cd concentrations (rs= 0.854, p= 0.000). The appearances of syncytial knot (STK) and fibrinoid deposit (Fd) were obviously greater in H-Cd group than in L-Cd group (p= 0.007, p= 0.026). The STK was positively correlated with both Fd (rs= 0.572, p= 0.032) and P-Cd concentration (rs= 0.766, p= 0.001). Although the chorioamnitis and decidual inflammation features were found in both groups but the appearance in H-Cd group seems to be more severe than in L-Cd group. From these results, we suggested that high Cd level in placenta may be involved in morphological changes, especially STK and Fd increasing and probably disturb the connection between maternal and fetal circulation.

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“…Special consideration has been given to interactions occurring between toxic metals and bioelements essential for life [2][3][4][5][6][7][8][9]. With the similarity in structure and chemical properties, Cd, as one of the toxic metals, and Zn, as one of the bioelements essential for life, are a pair of antagonists in organism [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

CE with on‐line detection by ICP‐MS for studying the competitive binding of zinc against cadmium for glutathione

Liu

Jiang

et al. 2008

Electrophoresis

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Development of a feasible method for studying the competitive interaction between a pair of antagonists is essential for understanding the antagonism of trace metals in biological systems. Herein, we report the application of CE on-line coupled with ICP mass spectroscopy (CE-ICP-MS) to investigate the competitive binding of Zn(2+) against Cd(2+) for glutathione (GSH), which is related to the detoxification of Cd(2+) in biological system, and introduce a method to evaluate the kinetics and thermodynamics for the competitive binding of Zn(2+) against Cd(2+) for GSH. The CE-ICP-MS hybrid technique allows easy and sensitive probing of the competitive binding of Zn(2+) against Cd(2+) for GSH and quantitative determination of the important thermodynamic and kinetic parameters of the competitive binding of Zn(2+) against Cd(2+) for GSH. Owing to the high sensitivity and element selectivity with multi-elements detection capacity of ICP-MS, we detailed the evaluation of the kinetics and thermodynamics describing the competition of Zn(2+) against Cd(2+) for GSH from the systematic data obtained by CE-ICP-MS. The competitive binding of Zn(2+) against Cd(2+) for GSH was demonstrated exothermic and thermodynamically favorable (DeltaG = -7.2 kJ/mol) and driven entirely by a large favorable enthalpy decrease (DeltaH = -15.1 kJ/mol) but with an unfavorable entropy decrease (DeltaS = -25.6 J/mol/K). The kinetic data were fit to a second-order equation with the reaction rate constant (k) of (2.18+/-0.10)x10(2) L/(mol x s) under the simulated physiological condition.

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The effects of air pollution and smoking on placental cadmium, zinc concentration and metallothionein expression

Cited by 60 publications

References 44 publications

Expression of Metallothioneins in Placental and Fetal Tissues in Undisturbed and PGM-Zn Treated Syngeneic Pregnancy

Expression of Metallothioneins in Placental and Fetal Tissues in Undisturbed and PGM-Zn Treated Syngeneic Pregnancy

Increasing of Syncytial Knot and Fibrinoid Deposit in High-Cd Accumulated Human Placentas

CE with on‐line detection by ICP‐MS for studying the competitive binding of zinc against cadmium for glutathione

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