The effects of air pollution toxicants on the mitochondria

Kochi, Camila; Ahmad, Shama; Salim, Samina

doi:10.1016/b978-0-323-88462-4.00004-3

Cited by 4 publications

(1 citation statement)

References 126 publications

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“…Indoor dust and air may represent an exposure source for environmental mitochondrial toxins. Exposure to mitochondrial toxins, specifically, to persistent anthropogenic mitochondrial toxins, is recognized as a potential hazard affecting both indoor and outdoor ecosystems [ 88 , 89 , 90 , 91 , 92 ].…”

Section: Discussionmentioning

confidence: 99%

Toxicity Screening of Fungal Extracts and Metabolites, Xenobiotic Chemicals, and Indoor Dusts with In Vitro and Ex Vivo Bioassay Methods

Hintikka,

Andersson,

Lundell

et al. 2024

Pathogens

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It is controversial how useful bioassays are for identifying the in vivo toxicity of hazardous environmental exposures. In this study, fruiting bodies of forest mushrooms (n = 46), indoor mold colonies (n = 412), fungal secondary metabolites (n = 18), xenobiotic chemicals such as biocides and detergents (n = 6), and methanol extracts of indoor dusts from urban buildings (n = 26) were screened with two different bioactivity assays: boar sperm motility inhibition (BSMI) and inhibition of cell proliferation (ICP) tests. For the forest mushrooms, the toxicity testing result was positive for 100% of poisonous-classified species, 69% of non-edible-classified species, and 18% of edible-classified species. Colonies of 21 isolates of Ascomycota mold fungal species previously isolated from water-damaged buildings proved to be toxic in the tests. Out of the fungal metabolites and xenobiotic chemicals, 94% and 100% were toxic, respectively. Out of the indoor dusts from moldy-classified houses (n = 12) and from dry, mold-free houses (n = 14), 50% and 57% were toxic, respectively. The bioassay tests, however, could not differentiate the samples from indoor dusts of moldy-classified buildings from those from the mold-free buildings. Xenobiotic chemicals and indoor dusts were more toxic in the BSMI assay than in the ICP assay, whereas the opposite results were obtained with the Ascomycota mold colonies and fungal secondary metabolites. The tests recognized unknown methanol-soluble thermoresistant substances in indoor settled dusts. Toxic indoor dusts may indicate a harmful exposure, regardless of whether the toxicity is due to xenobiotic chemicals or microbial metabolites.

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Section: Discussionmentioning

confidence: 99%

Toxicity Screening of Fungal Extracts and Metabolites, Xenobiotic Chemicals, and Indoor Dusts with In Vitro and Ex Vivo Bioassay Methods

Hintikka,

Andersson,

Lundell

et al. 2024

Pathogens

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Role of Pollution-Induced Oxidative Stress and Inflammation in Neurodegenerative Diseases, and the Mechanisms of Traditional Chinese Medicine’s Potential Remediation

Yang,

Yin,

Yang

et al. 2024

Reviews Env.Contamination (formerly:Residue Reviews)

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Morphological changes in liver tissues of rats under the exposure of ecotoxicants and perinatal prophylaxis

Chuikin,

Musina,

Galiakhmetova

et al. 2023

Morphology

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The aim of the study was to study the morphological changes in the liver tissues of laboratory rats under the influence of ecotoxicants and during perinatal prophylaxis. The experiment was carried out on white outbred rats weighing 180-250. A total of 50 animals were involved in the experiment. All animals were divided into 5 groups: control and 4 experimental. All animals of the experimental groups were subjected to inhalation effects of gasoline and formaldehyde vapors, in the 1st (control) group, only poisoning with ecotoxicants was used, in the 2nd group, against the background of poisoning with ecotoxicants, peptinsorbent was used, in the 3rd group - a membrane protector - magnolia vine, in the 4th group beets, in the 5th experimental group - peptinsorbent, membrane protector and beets. The structure of the liver of rat pups born from female rats subjected to subchronic poisoning with gasoline and formaldehyde throughout pregnancy has pronounced pathomorphological signs characteristic of hepatosis, turning into toxic hepatitis. The use of lemongrass, peptinsorbent and beetroot separately, along with intoxication of pregnant rats, somewhat reduced the degree of pathomorphological changes in the liver of born rats, but not drastically. Against the background of using a combined mixture (peptinsorbent + lemongrass "membrane protector" + beetroot) in subsequently born rat pups, the structure of the liver is relatively better than in the control group, with the exception of certain areas of the liver, in which hemostasis and moderately pronounced dystrophic changes in hepatocytes are detected. Based on the results of the experimental study, it can be concluded that the combined mixture (peptinsorbent + lemongrass "membranoprotector" + beetroot) is effective as a hepatoprotective agent for liver damage by ecotoxicants.

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The effects of air pollution toxicants on the mitochondria

Cited by 4 publications

References 126 publications

Toxicity Screening of Fungal Extracts and Metabolites, Xenobiotic Chemicals, and Indoor Dusts with In Vitro and Ex Vivo Bioassay Methods

Toxicity Screening of Fungal Extracts and Metabolites, Xenobiotic Chemicals, and Indoor Dusts with In Vitro and Ex Vivo Bioassay Methods

Role of Pollution-Induced Oxidative Stress and Inflammation in Neurodegenerative Diseases, and the Mechanisms of Traditional Chinese Medicine’s Potential Remediation

Morphological changes in liver tissues of rats under the exposure of ecotoxicants and perinatal prophylaxis

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