The effects of age on neural correlates of recognition memory: An fMRI study

Hou, Mingzhu; Wang, Tracy H.; Rugg, Michael D.

doi:10.1016/j.bandc.2021.105785

Cited by 9 publications

(18 citation statements)

References 77 publications

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“…These null findings are consistent with prior reports of absent or very limited effects of age in studies of episodic memory retrieval (e.g. Wang et al, 2016;Hou et al, 2021;de Chastelaine et al 2016b;2017). There were, however, robust main effects of age in each striatal region.…”

Section: Discussionsupporting

confidence: 90%

Patterns of retrieval-related cortico-striatal connectivity are stable across the adult lifespan

Hill

Chastelaine²,

Rugg

2022

Cerebral Cortex

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Memory retrieval effects in the striatum are well documented and robust across experimental paradigms. However, the functional significance of these effects, and whether they are moderated by age, remains unclear. We used functional magnetic resonance imaging paired with an associative recognition task to examine retrieval effects in the striatum in a sample of healthy young, middle-aged, and older adults. We identified anatomically segregated patterns of enhanced striatal blood oxygen level-dependent (BOLD) activity during recollection- and familiarity-based memory judgments. Successful recollection was associated with enhanced BOLD activity in bilateral putamen and nucleus accumbens, and neither of these effects were reliably moderated by age. Familiarity effects were evident in the head of the caudate nucleus bilaterally, and these effects were attenuated in middle-aged and older adults. Using psychophysiological interaction analyses, we observed a monitoring-related increase in functional connectivity between the caudate and regions of the frontoparietal control network, and between the putamen and bilateral retrosplenial cortex and intraparietal sulcus. In all instances, monitoring-related increases in cortico-striatal connectivity were unmoderated by age. These results suggest that the striatum, and the caudate in particular, couples with the frontoparietal control network to support top-down retrieval-monitoring operations, and that the strength of these inter-regional interactions is preserved in later life.

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Section: Discussionsupporting

confidence: 90%

Patterns of retrieval-related cortico-striatal connectivity are stable across the adult lifespan

Hill

Chastelaine²,

Rugg

2022

Cerebral Cortex

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“…Prior studies comparing recollection effects in cognitively healthy young and older adults have reported largely age-invariant effects in core recollection regions (de Chastelaine et al, 2016;Dulas and Duarte, 2012;Folville et al, 2020;Hou et al, 2021Hou et al, , 2022, especially when memory performance was matched or statistically equated between age groups (for exceptions, see Angel et al, 2013;Daselaar et al, 2006). These findings suggest that recollection effects are largely unaffected by increasing age, but the time courses of the effects have yet to be examined in older adults.…”

Section: Introductionmentioning

confidence: 95%

The effects of age on neural correlates of recollection: transient versus sustained fMRI effects

Hou

Chastelaine

Rugg

2023

Preprint

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Prior fMRI findings in young adults indicate that recollection-sensitive neural regions dissociate according to the time courses of their respective recollection effects. Here, we examined whether such dissociations are also evident in older adults. Young and older participants encoded a series of word-object image pairs, judging which of the denoted objects was the smaller. At test, participants first judged whether a test word was old or new. For items judged old, they were required to recall the associated image and hold it in mind across a variable delay period. A post-delay cue denoted which of three judgments should be made on the retrieved image. Older adults demonstrated significantly lower associative memory performance than young adults. Replicating prior findings, transient recollection effects were identified in the left hippocampus, medial prefrontal cortex and posterior cingulate, while sustained effects were widespread across left lateral cortex and were also evident in the bilateral striatum. With the exception of those in the left insula, all effects were age-invariant. These findings add to the evidence that recollection-related BOLD effects in different neural regions can be temporally dissociated. Additionally, the findings suggest that both transient and sustained recollection effects are largely stable across much of the healthy adult lifespan.

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“…The parahippocampal cortex showed either a positive linear (see Figure 1a) (Kafkas et al, 2017; Woroch et al, 2019) or a recognition threshold pattern (see Figure 1b) (Johnson et al, 2013), and the hippocampus displayed mainly a recognition threshold pattern (Cohn et al, 2009; Daselaar, Fleck, Dobbins, et al, 2006; Johnson et al, 2013; Kafkas et al, 2017; Kafkas & Montaldi, 2012; Kirwan et al, 2009; Montaldi et al, 2006; Slotnick & Thakral, 2013; Wang, Rogers, et al, 2014). Interestingly, the hippocampus can also show a U‐shaped pattern (see Figure 1c) (Hou et al, 2021; Johnson et al, 2013; Kafkas & Montaldi, 2012; Mugikura et al, 2010), suggesting that activity in the hippocampus increases when high‐confident responses are made, irrespective of memory status (Chua et al, 2006; Kim & Cabeza, 2009).…”

Section: Retrieval‐related Brain Activitymentioning

confidence: 99%

“…As was the case for the VLPFC, effects in the DLPFC seem to be mostly left‐lateralized and diverse in nature. Confidence‐related activity patterns in the DLPFC mainly show a positive linear pattern (Cohn et al, 2009; Hou et al, 2021; Hutchinson et al, 2015; Johnson et al, 2013; Kafkas & Montaldi, 2012; Mayes et al, 2019), but various other patterns are also reported (Daselaar, Fleck, & Cabeza, 2006; Fleck et al, 2006; Hutchinson et al, 2015; Johnson et al, 2013; Kafkas & Montaldi, 2012; Montaldi et al, 2006). Therefore, it appears that the DLPFC is involved in the subjective aspects of recognition memory, but that the specific relation is not uniform.…”

Section: Retrieval‐related Brain Activitymentioning

confidence: 99%

“…Just as with the VPC regions, activity in DPC regions has been shown to increase with memory confidence (Cohn et al, 2009; Daselaar, Fleck, Dobbins, et al, 2006; Hou et al, 2021; Hutchinson et al, 2015; Johnson et al, 2013; Mayes et al, 2019; Montaldi et al, 2006; Yonelinas et al, 2005). However, the DPC regions do not seem to show increased activity in remember or high‐confident old responses (Cohn et al, 2009; Daselaar, Fleck, & Cabeza, 2006; Hou et al, 2021; Hutchinson et al, 2015; Johnson et al, 2013; Kim & Cabeza, 2009; Mayes et al, 2019; Yonelinas et al, 2005) and activity can show a negative linear pattern (Daselaar, Fleck, Dobbins, et al, 2006; Fleck et al, 2006; Woroch et al, 2019), indicating that these regions might be of greater importance when there is memory uncertainty. This interpretation is supported by reports of an inverted U‐shaped relation between DPC regions and memory confidence (Hutchinson et al, 2015; Moritz et al, 2006).…”

Section: Retrieval‐related Brain Activitymentioning

confidence: 99%

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Brain activity patterns underlying memory confidence

Wynn

Nyhus

2022

Eur J of Neuroscience

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The primary aim of this review is to examine the brain activity patterns that are related to subjectively perceived memory confidence. We focus on the main brain regions involved in episodic memory: the medial temporal lobe (MTL), prefrontal cortex (PFC), and posterior parietal cortex (PPC), and relate activity in their subregions to memory confidence. How this brain activity in both the encoding and retrieval phase is related to (subsequent) memory confidence ratings will be discussed. Specifically, encoding related activity in MTL regions and ventrolateral PFC mainly shows a positive linear increase with subsequent memory confidence, while dorsolateral and ventromedial PFC activity show mixed patterns. In addition, encoding‐related PPC activity seems to only have indirect effects on memory confidence ratings. Activity during retrieval in both the hippocampus and parahippocampal cortex increases with memory confidence, especially during high‐confident recognition. Retrieval‐related activity in the PFC and PPC show mixed relationships with memory confidence, likely related to post‐retrieval monitoring and attentional processes, respectively. In this review, these MTL, PFC, and PPC activity patterns are examined in detail and related to their functional roles in memory processes. This insight into brain activity that underlies memory confidence is important for our understanding of brain–behaviour relations and memory‐guided decision making.

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The effects of age on neural correlates of recognition memory: An fMRI study

Cited by 9 publications

References 77 publications

Patterns of retrieval-related cortico-striatal connectivity are stable across the adult lifespan

Patterns of retrieval-related cortico-striatal connectivity are stable across the adult lifespan

The effects of age on neural correlates of recollection: transient versus sustained fMRI effects

Brain activity patterns underlying memory confidence

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