The effects of age on the N200 component of the auditory event-related potentials

Enoki, Hideo; Sanada, Satoshi; Yoshinaga, Harumi; Oka, Eiji; Ohtahara, Shunsuke

doi:10.1016/0926-6410(93)90023-x

Cited by 59 publications

(42 citation statements)

References 18 publications

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“…However, other studies have found no changes in N2 amplitude with advancing age (Brown et al 1983;Picton et al 1984;Barrett et al 1987) and even increases at central and parietal scalp sites (Iragui et al 1993;Enoki et al 1993) which might explain N1 and N2 amplitude increment at Cz from 20 to 45 years in our scatter-plot (Figs. 3, 5).…”

mentioning

confidence: 39%

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

et al. 2014

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Auditory event-related potentials (AERPs) are widely used in diverse fields of today's neuroscience, concerning auditory processing, speech perception, language acquisition, neurodevelopment, attention and cognition in normal aging, gender, developmental, neurologic and psychiatric disorders. However, its transposition to clinical practice has remained minimal. Mainly due to scarce literature on normative data across age, wide spectrum of results, variety of auditory stimuli used and to different neuropsychological meanings of AERPs components between authors. One of the most prominent AERP components studied in last decades was N1, which reflects auditory detection and discrimination. Subsequently, N2 indicates attention allocation and phonological analysis. The simultaneous analysis of N1 and N2 elicited by feasible novelty experimental paradigms, such as auditory oddball, seems an objective method to assess central auditory processing. The aim of this systematic review was to bring forward normative values for auditory oddball N1 and N2 components across age. EBSCO, PubMed, Web of Knowledge and Google Scholar were systematically searched for studies that elicited N1 and/or N2 by auditory oddball paradigm. A total of 2,764 papers were initially identified in the database, of which 19 resulted from hand search and additional references, between 1988 and 2013, last 25 years. A final total of 68 studies met the eligibility criteria with a total of 2,406 participants from control groups for N1 (age range 6.6-85 years; mean 34.42) and 1,507 for N2 (age range 9-85 years; mean 36.13). Polynomial regression analysis revealed that N1 latency decreases with aging at Fz and Cz, N1 amplitude at Cz decreases from childhood to adolescence and stabilizes after 30-40 years and at Fz the decrement finishes by 60 years and highly increases after this age. Regarding N2, latency did not covary with age but amplitude showed a significant decrement for both Cz and Fz. Results suggested reliable normative values for Cz and Fz electrode locations; however, changes in brain development and components topography over age should be considered in clinical practice.

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confidence: 39%

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

et al. 2014

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“…While most studies have shown that the N2 decreases in size across adolescence (Cunningham et al, 2000;Enoki et al, 1993;Johnstone et al, 1996;Oades et al, 1997;Ponton et al, 2000;Satterfield and Braley, 1977), some studies report no change in N2 amplitude with age (Johnson, 1989;Martin et al, 1988;TonnquistUhlen, 1996). Interestingly, Goodin et al (1978) reported that N2 amplitude increased until 14 years and then decreased from 15 years until adulthood.…”

Section: Introductionmentioning

confidence: 95%

“…The latency of P2 shows no agerelated change in childhood (Wunderlich and Cone-Wesson, 2006). And, finally, the auditory N2 appears to decrease in size and in latency from the ages of 5e10 years (Enoki et al, 1993;Ponton et al, 2000).…”

Section: Introductionmentioning

confidence: 97%

Maturation of auditory event-related potentials across adolescence

Mahajan

McArthur

2012

Hearing Research

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“…The different results might be related to differences in the degree of stimulus contrasts. Typically, large and easily discriminable deviations of the target from the standard stimulus, such as 1 versus 2 kHz, have been used in studies reporting smaller (Enoki et al 1993;Friedman et al 1993;Iragui et al 1993;Anderer et al 1996) Amenedo and Diaz 1998b) in the elderly. Fitzgerald and Picton (1983) found that N2b increased significantly with increasing discrimination difficulty.…”

Section: Effects Of Agementioning

confidence: 99%

Effects of Age, Age-Related Hearing Loss, and Contralateral Cafeteria Noise on the Discrimination of Small Frequency Changes: Psychoacoustic and Electrophysiological Measures

Bertoli

Smurzyński

Probst

2005

JARO

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The aim of the study was to examine central auditory processes compromised by age, age-related hearing loss, and the presentation of a distracting cafeteria noise using auditory event-related potentials (ERPs). In addition, the relation of ERPs to behavioral measures of discrimination was investigated. Three groups of subjects participated: young normal hearing, elderly subjects with normal hearing for their age, and elderly hearing-impaired subjects. Psychoacoustic frequency discrimination thresholds for a 1000-Hz pure tone were determined in quiet and in the presence of a contralateral cafeteria noise. To elicit ERPs, small frequency contrasts were presented with and without noise under unattended and attended conditions. In the attended condition, behavioral measures of dS detectability and reaction times were also obtained. Noise affected all measures of behavioral frequency discrimination significantly. Except N1, all ERP components in the standard and difference waveforms decreased significantly in amplitude and increased in latency to the same degree in all three subject groups, arguing against a specific age-related sensitivity to the effects of contralateral background noise. For N1 amplitude, the effect of noise was different in the three subject groups, with a complex interaction of age, hearing loss, and attention. Behavioral frequency discrimination was not affected by age but deteriorated significantly in the elderly subjects with hearing loss. In the electrophysiological test, age-related changes occurred at various levels. The most prominent finding in the response to the standard stimuli was a sustained negativity (N2) following P2 in the young subjects that was absent in the elderly, possibly indicating a deficit in the inhibition of irrelevant information processing. In the attended difference waveform, significantly larger N2b and smaller P3b amplitudes and longer N2b and P3b latencies were observed in the elderly indicating different processing strategies. The pronounced agerelated changes in the later cognitive components suggest that the discrimination of difficult contrasts, although behaviorally maintained, becomes more effortful in the elderly.

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The effects of age on the N200 component of the auditory event-related potentials

Cited by 59 publications

References 18 publications

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

Maturation of auditory event-related potentials across adolescence

Effects of Age, Age-Related Hearing Loss, and Contralateral Cafeteria Noise on the Discrimination of Small Frequency Changes: Psychoacoustic and Electrophysiological Measures

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