The effects of aerobic exercise on sleep quality measures and sleep-related biomarkers in individuals with Multiple Sclerosis: A pilot randomised controlled trial

Al‐Sharman, Alham; Khalil, Hanan; El‐Salem, Khalid; Aldughmi, Mayis; Aburub, Aseel

doi:10.3233/nre-192748

Cited by 36 publications

(63 citation statements)

References 36 publications

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“…46 As to the mechanism of physical activity improving sleep quality, melatonin works to regulate the sleep/wake cycle, and aerobic exercise can increase brain serotonin level, which indirectly improves sleep quality by increasing melatonin level. 47 The present study has the following limitations that should be taken into account. First, this is a cross-sectional study limited to women in early pregnancy.…”

Section: Discussionmentioning

confidence: 95%

Dietary patterns in relation to gestational depression and sleep disturbance in Chinese pregnant women

Zhan

Feng

et al. 2020

J of Obstet and Gynaecol

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Aim: To investigate the association of dietary patterns with gestational depression and sleep disturbance. Methods: Women in early pregnancy were recruited from the Chinese Pregnant Women Cohort Study (CPWCS) through July 25th, 2017 to November 26th, 2018, and eventually 7615 participants were included in this study. The qualitative food frequency questionnaire (Q-FFQ), Edinburgh Postnatal Depression Scale (EPDS), and the Pittsburgh Sleep Quality Index (PSQI) were used to assess dietary, depression and sleep quality during pregnancy, respectively. Dietary patterns were derived by factor analysis. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (95% CI) of each outcome according to quartiles of each dietary pattern. Results: Five dietary patterns were identified. Participants with the highest quartile in plant-based pattern had a significantly lower likelihood of mental problems (OR: 95% CI for depression: 0.66, 0.55-0.79; sleep disturbance: 0.80, 0.68-0.93); Similar results were observed in vitamin-rich pattern (OR: 95% CI for depression: 0.46, 0.38-0.55; sleep disturbance: 0.76, 0.65-0.89); However, contrary results were found in high-fat pattern (OR: 95% CI for depression: 2.15, 1.25-1.85; sleep disturbance: 1.43, 1.22-1.67); In animal protein-rich pattern, participants with the highest quartile had a decreased likelihood of depression (OR: 0.80, 95% CI: 0.67-0.96). As for bean products pattern, participants with the highest quartile had an increased risk of depression (OR: 1.28, 95% CI:1.06-1.53). Interactions of dietary patterns and lifestyles on mental disorders were observed. Conclusion: Dietary patterns were associated with gestational depression and sleep disturbance. Relevant departments and maternal and child health personnel should conduct health education for pregnant women and guide them to eat properly.

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Section: Discussionmentioning

confidence: 95%

Dietary patterns in relation to gestational depression and sleep disturbance in Chinese pregnant women

Zhan

Feng

et al. 2020

J of Obstet and Gynaecol

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“…A study conducted in 2016 showed that physical activity decreases the fatigue severity scale (FSS), and the study associated this improvement with an elevation of the 5-HT levels present in the same group [22]. Likewise, a randomized controlled trial (RCT) in 2019 showed an increase in 5-HT levels with aerobic exercise, and it associated this phenomenon with the improvement in the participants' sleep quality [23]. Although both studies had a small sample size, the results are promising for future therapies on targeting the serotonergic system to improve the overall health of MS patients and their quality of life.…”

Section: Figure 2: Serotonin's Effects On the Immune Systemmentioning

confidence: 99%

Multiple Sclerosis and Serotonin: Potential Therapeutic Applications

Hernandez¹,

Singh²,

Valero³

et al. 2020

Cureus

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Multiple sclerosis (MS) is a neurodegenerative disease with a complex autoimmune component, and it has a high prevalence among middle-aged females. The manifestations of the disease range from episodic somatosensory dysfunction to progressive and permanent central nervous system (CNS) damage. Due to a high prevalence of psychiatric comorbidities and proven abnormalities in serotonin (5-HT) levels among MS patients, they are usually on drugs that modify the serotonergic system. Through a comprehensive literature review of studies published in the last 10 years related to 5-HT in MS and its therapeutic applications, we aimed to elucidate the mechanism behind the neurotransmitter (NT) levels' abnormalities. Most importantly, we endeavored to gather the most up-to-date information about the full therapeutic potential of agents acting on this system. We discovered that multiple processes cause low levels of 5-HT in MS patients. The varying levels of the availability of the 5-HT transporter (SERT) in the CNS decreasing overall tryptophan (TRP) levels, and diversion of the amino acid away from its synthetic pathway constitute some of those. Studies in animals have shown that 5-HT levels' elevations could cause immune-modulating effects and could probably slow down the disease progression rate. Human studies have shown a more diverse and complex response. Promising results have been obtained in the last 10 years regarding 5-HT's immunemodulatory role in MS patients and its therapeutic applications. Human studies with a larger population and feasible designs are still needed to fully ascertain the effects of serotonin on the immune system and disease progression in patients with MS.

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“…Physical exercise combined with dietary stringency and regulation, and in many cases restriction, promotes various aspects of cardiovascular and metabolic health through the induction of a direct impact upon the vascular endothelium as well as other physiological factors mediating cellular homeostasis and functioning. For example, exercise may be a non-pharmacological, inexpensive, safe method to improve sleep quality in people presenting multiple sclerosis [1] with profound therapeutic effects over a variety of disorder condition and health-promoting proclivities [2][3][4][5][6][7][8]. Additionally, over a wide sphere of chronicallydebilitating communicable and non-communicable disease states are ameliorated by physical exercise schedules, relatively independent of type, duration and intensity, especially if maintained on a chronic-regular basis [4].…”

Section: Literature Reviewmentioning

confidence: 99%

Health Benefit Manifestation of Improved Sleep, Physical Exercise and Selective Diets

Archer¹,

Ricciardi²

2019

Diversity & Equality

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The conflicting and vicarious demands of occupations schedules, stressful life situations, unrestricted dietary habits, sedentary lifestyles and metabolic compromization present some of the hazards that culminate in individuals' sleep problems whether de facto experience, physiological expressions of health parameters or disorder/drug-related. Interventional therapies aimed at the avoidance of damaging insulin resistance and type II diabetes conditions extend the physical exercise benefits by their influences upon skeletal muscle tissue, with in addition exercise training inducing profound effects on adipose tissue. Regular exercise precludes nocturnal disturbance with associations to reductions in the prevalence of sleep disorders, i.e. most particularly obstructive sleep apnea and thereby improving sleep efficiency and integrity among, and across, most age-groups. In obstructive sleep apnea patients, dysregulated cardiovascular health, that may or may not counteract the elevated oxidative stress, proinflammatory development and sympathetic activation may alleviated through selective regimes of physical exercise. The presence of major gender difference in the quality and sufficiency of healthy sleep reinforces the requirement for selective lifestyles to combat the encroachment of sleep inadequacy as a health hazard. Proper assessment of somatic and psychological health variables requires major planning and preparation.

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The effects of aerobic exercise on sleep quality measures and sleep-related biomarkers in individuals with Multiple Sclerosis: A pilot randomised controlled trial

Cited by 36 publications

References 36 publications

Dietary patterns in relation to gestational depression and sleep disturbance in Chinese pregnant women

Dietary patterns in relation to gestational depression and sleep disturbance in Chinese pregnant women

Multiple Sclerosis and Serotonin: Potential Therapeutic Applications

Health Benefit Manifestation of Improved Sleep, Physical Exercise and Selective Diets

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