The Effects of Adrenergic Blocking Agents on Passive Cutaneous Anaphylaxis Reactions in the Rat

Tolone, G.; Bonasera, L.; Bruno, Richard S.

doi:10.1159/000162321

Cited by 6 publications

(5 citation statements)

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“…Secondly, while there is less evidence to link catecholamines with the type of non-chronic infectious diseases reported in this study, anti-inflammatory properties of catecholamines have been described [35,36]. Qualliotine [37,38] reported that catecholamines reduced the bactericidal activity of leukocytes, and Ignarro and Colombo [39] have shown that catecholamines and cyclic-AMP inhibit the osmotic release of /3-glucuronidase from leukocyte lysosomes.…”

Section: Resultsmentioning

confidence: 73%

Catecholamine activity and reported morbidity

Gruchow

1976

Journal of Chronic Diseases

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Abstract:Urinary VMA levels were measured in relation to the reporting of morbidity in an attempt to determine whether altered catecholamine activity is related to specific disease syndromes, or is a general characteristic of morbidity. The cross-sectional data show elevated VMA levels to be associated with the reporting of chronic disease conditions; non-chronic conditions and affective disorders were associated with lower VMA values, Although these findings are interpreted as supporting the hypothesis that psycho-social stimuli acting through the sympathetic-adrenal medullary system may be important in the etiology of chronic disease conditions, alternative explanations are discussed and the need for further longitudinal studies indicated. Article:INTRODUCTION DURING the past several decades, the study of relationships between psychosocial factors and disease has led to better understanding of both the psychosocial events which may trigger or enhance disease processes, and the physiological mechanisms involved. Investigators are now in substantial agreement that psychosocial events can play an etiological role in a variety of different diseases. However, despite this progress, it is still unclear how these events are translated into disease states.Two different approaches have generally been taken to study this problem. One approach holds that there is a degree of specificity in these relationships, with certain types of psychosocial events more often associated with one type of pathophysiologic condition than other types. This approach is illustrated by numerous studies which have successfully demonstrated that specific disease entities such as tuberculosis [1,2], hypertension [3][4][5], coronary heart disease [6], cancer [7,8], rheumatoid arthritis [9,10], and even complications of pregnancy [11, 12] can be related to certain psychosocial events or to certain individual behavior patterns.Other investigators have taken a second approach, in which the general nature of a person's interactions within the social environment is related to overall morbidity [13][14][15][16][17], and increased morbidity of all types has been related to perception of `...life situations as demanding, threatening and frustrating ' [18].A way to begin resolving this question of causality is to evaluate both the morbidity and the presumed psychosocial risk factors for a common physiological link. One such physiological intermediary appears to be the sympathetic-adrenal medullary system, Elevated levels of the catecholamines and their metabolites have been reported in experimental subjects associated with exposure to various types of psychosocial stimuli [19]. Furthermore, increased catecholamine levels have been reported for several disease states including angina [20], hypertension [21,22] and gastric and duodenal ulcers [23,24]. In addition, elevated catecholamine activity has been suggested as a possible factor in the etiology of diabetes [25,26], and a beta adrenergic mechanism has been proposed as a central element in the develo...

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Section: Resultsmentioning

confidence: 73%

Catecholamine activity and reported morbidity

Gruchow

1976

Journal of Chronic Diseases

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“…BOL and methysergide both were found ineffective against heterologous hyperim mune antibody-mediated PCA by Levy [10] and us, respectively. /J-adrenergic sympathomimetic agents have been reported to be active against both reagin-mediated PCA [1,5,13] and against hyperimmune antibody-mediated PCA [3,22], Our comparatively more detailed data suggest that individual /J-sympathomimetic drugs may have different effi cacies and dose-response slopes against reagin and hyperimmune antibody-metiated PCA systems. If these observations can be confirmed by extending the dose and time parameters beyond those used in these experi ments, then it might indicate possible involvement of additional selective inhibitory mechanisms, besides stimulation of adenyl cyclase which is a commonly accepted mechanism of inhibition of anaphylactic reactions by /J-adrenergic sympathomimetic drugs [2,18].…”

Section: Discussionmentioning

confidence: 99%

Effects of Anti-Anaphylactic Drugs upon Passive Cutaneous Anaphylaxis Mediated by Graded Doses of Reaginic or Non-Reaginic Antibodies in Rats

Mielens¹,

Ferguson²,

Rosenberg³

1974

Int Arch Allergy Immunol

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The sizes of passive cutaneous anaphylaxis (PCA) reactions, mediated by reagin or hyperimmune antibodies, were directly related to the degree of sensitization and, to a lesser degree, to the dose of the challenging antigen. Inhibition by anti-anaphylactic drugs of both types of PCA was inversely related to the degree of sensitization. Anti-anaphylactic drugs shifted the diameter-antibody concentration slopes to the region of higher antibody concentration in a parallel manner which suggests a possible competitive nature of the inhibitory mechanisms of these drugs. Disodium cromoglycate and methysergide were effective against reagin-mediated PCA but they were ineffective against hyperimmune antibody-mediated PCA. Then-yldiamine and chlorpheniramine had marginal activities against both PCA systems. Aminophylline was effective against both systems and it had similar potencies and efficacies against both types of PCA. Three β-adrenergic sympathomimetic drugs were more efficacious against hyperimmune antibody-mediated PCA than against reagin-mediated PCA.

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“…The anti-inflammatory action of certain catecholamines in various animal models of acute (14,15) and chronic inflammation (16,17) has been reported. In fact, catecholamines have been thought to play a regulatory role in the inflammatory process (18).…”

Section: (From the Departments Of Pharmacology And Biochemistry Tulamentioning

confidence: 99%

Hormonal Control of Lysosomal Enzyme Release From Human Neutrophils

Ignarro

Lint

George

1974

The Journal of Experimental Medicine

110

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Release of lysosomal enzymes from phagocytic leukocytes in the presence of various immune reactants is well documented (1-6). The tissue injury that results from the accumulation of, and phagocytosis by, granulocytes is probably a direct consequence of the extracellular release of granule constituents (7,8). Indeed, lysosome granules proteins are capable of mediating inflammation (9, 10) and cartilage degradation (11-13).The anti-inflammatory action of certain catecholamines in various animal models of acute (14, 15) and chronic inflammation (16, 17) has been reported. In fact, catecholamines have been thought to play a regulatory role in the inflammatory process (18). More recent studies have uncovered specific actions of catecholamines at the cellular and organelle level. For example, certain sympathomimetic amines were reported to inhibit the allergic release of histamine from sensitized human leukocytes (19) and lung fragments (20). In both of these studies it was suggested that the actions of the catecholamines were mediated by cyclic AMP. Release of enzymes from isolated lysosomes was also inhibited by epinephrine, norepinephrine, isoproterenol, theophylline, and cyclic AMP (21-24).In order to understand more completely the anti-inflammatory effects of catecholamines at the cellular level, several adrenergic and cholinergic amines and cyclic nucleotides were tested for their capacity to modify the release of /~-glucuronidase, a lysosomal marker enzyme, from and particle ingestion by human neutrophils during phagocytic uptake of serum-treated zymosan particles. In addition, the effects of autonomic neurohormones on neutrophil levels of cyclic AMP and cyclic GMP were determined in order to assess the possible involvement of cyclic nucleotides in mediating the actions of the neurohormones on phagocytic enzyme release. Preliminary reports of some of the present findings appeared earlier (25,26).

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The Effects of Adrenergic Blocking Agents on Passive Cutaneous Anaphylaxis Reactions in the Rat

Cited by 6 publications

References 5 publications

Catecholamine activity and reported morbidity

Catecholamine activity and reported morbidity

Effects of Anti-Anaphylactic Drugs upon Passive Cutaneous Anaphylaxis Mediated by Graded Doses of Reaginic or Non-Reaginic Antibodies in Rats

Hormonal Control of Lysosomal Enzyme Release From Human Neutrophils

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